The solubility of H9377 has been tested at a concentration of 50 mg/ml in a mixture of 2 parts formic acid to 1 part water, equivalent to a 5% solution. While this may not represent the maximum solubility in the formic acid water mixture, it is the available data. The molecular weight of Hypoxanthine is 136.11 amu, and a 1M solution can be prepared by dissolving 136.11 grams in 1 liter of solvent, provided that there is a suitable solvent for dissolution. This amount can be scaled down to the desired volume. Aliquots should be stored at -20°C for up to 6 months.
H9377
Hypoxanthine
≥99.0%, synthetic (organic), powder
Sinonimo/i:
6-Hydroxypurine
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1 G
65,70 €
5 G
135,00 €
25 G
203,00 €
100 G
545,00 €
65,70 €
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Informazioni su questo articolo
Formula empirica (notazione di Hill):
C5H4N4O
Numero CAS:
Peso molecolare:
136.11
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
200-697-3
MDL number:
Beilstein/REAXYS Number:
5811
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Permettici di aiutartiNome del prodotto
Hypoxanthine, ≥99.0%
InChI key
FDGQSTZJBFJUBT-UHFFFAOYSA-N
InChI
1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)
SMILES string
O=C1NC=Nc2nc[nH]c12
biological source
synthetic (organic)
assay
≥99.0%
form
powder
mp
>300 °C (lit.)
solubility
formic acid: water (2:1): 50 mg/mL, clear to slightly hazy, colorless to yellow
Quality Level
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Categorie correlate
1 of 4
Questo articolo | H9636 | 1191226 | Y0000441 |
|---|---|---|---|
| biological source synthetic (organic) | biological source - | biological source - | biological source - |
| Quality Level 300 | Quality Level 200 | Quality Level - | Quality Level - |
| form powder | form powder | form - | form - |
| assay ≥99.0% | assay ≥99% | assay - | assay - |
| solubility formic acid: water (2:1): 50 mg/mL, clear to slightly hazy, colorless to yellow | solubility formic acid: water (2:1): 50 mg/mL | solubility - | solubility - |
| mp >300 °C (lit.) | mp >300 °C (lit.) | mp >300 °C (lit.) | mp >300 °C (lit.) |
Application
Hypoxanthine is a nutrient additive for a variety of cell culture applications involving bacterial, parasite (Plasmodium falciparum) and animal cells. Hypoxanthine is a component of selection media used in hybridoma technologies.
Hypoxanthine has been used:
- to gavage mice and to evaluate the activity of xanthine oxidase (XO) in pasteurized whole milk in vivo in potassium oxonate (PO) -induced mouse model of hyperuricemia[1]
- as a supplement in Iscove′s modified Dulbecco′s medium (IMDM) medium to cultivate in-vitro cell line (EL-1 cells)[2]
- as a pure standard for the quantification of hypoxanthine in vitreous fluid sample using high-performance liquid chromatography-ultra-violet (HPLC-UV) for the estimation of post-mortem interval[3]
Biochem/physiol Actions
Hypoxanthine acts as an intermediate in purine metabolism. It elicits a vital role as a 5′-base of the anticodon in a few transfer-RNAs. Though similar to guanine (Gua), it is devoid of the exocyclic amino group at C(2) position.[4] It may be used as a substrate to study the specificity and kinetics of hypoxanthine-guanine phosphoribosyl transferases.[5]
Classe di stoccaggio
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Articoli
Uric acid present in animal sera impacts serum-supplemented classical cell culture systems, influencing cell culture performance.
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What are the instructions for preparing a 1M hypoxanthine stock solution?
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