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Merck

K1128

α-Ketoglutaric acid

BioReagent, suitable for cell culture, suitable for insect cell culture

Sinonimo/i:

2-Oxoglutaric acid, 2-Oxopentanedioic acid

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5 G

36,60 €

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58,50 €

100 G

199,00 €

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Informazioni su questo articolo

Formula condensata:
HOOCCH2CH2COCOOH
Numero CAS:
328-50-7
Peso molecolare:
146.10
UNSPSC Code:
12352204
NACRES:
NA.32
PubChem Substance ID:
24896202
EC Number:
206-330-3
Beilstein/REAXYS Number:
1705689
MDL number:
MFCD00004165

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Nome del prodotto

α-Ketoglutaric acid, BioReagent, suitable for cell culture, suitable for insect cell culture

InChI key

KPGXRSRHYNQIFN-UHFFFAOYSA-N

InChI

1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)

SMILES string

OC(=O)CCC(=O)C(O)=O

product line

BioReagent

assay

≥98.5% NaOH basis (titration)

form

powder or crystals

technique(s)

cell culture | insect: suitable
cell culture | mammalian: suitable

solubility

water: 100 mg/mL, clear to slightly hazy, colorless to almost colorless

storage temp.

2-8°C

Quality Level

200

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Questo articolo
K17507589061234
α-Ketoglutaric acid BioReagent, suitable for cell culture, suitable for insect cell culture

Sigma-Aldrich

K1128

α-Ketoglutaric acid

α-Ketoglutaric acid ≥98.5% (NaOH, titration)

Sigma-Aldrich

K1750

α-Ketoglutaric acid

α-Ketoglutaric acid 99.0-101.0% (T)

Sigma-Aldrich

75890

α-Ketoglutaric acid

α-Ketoglutaric acid analytical standard

Supelco

61234

α-Ketoglutaric acid

assay

≥98.5% NaOH basis (titration)

assay

≥98.5% (NaOH, titration)

assay

99.0-101.0% (T)

assay

99.0-101.0% (T)

solubility

water: 100 mg/mL, clear to slightly hazy, colorless to almost colorless

solubility

water: 100 mg/mL, clear to slightly hazy, colorless to faintly yellow

solubility

H2O: 1 g/10 mL, clear to slightly hazy, colorless to almost colorless

solubility

-

technique(s)

cell culture | insect: suitable, cell culture | mammalian: suitable

technique(s)

-

technique(s)

-

technique(s)

-

Quality Level

200

Quality Level

200

Quality Level

300

Quality Level

-

form

powder or crystals

form

powder

form

crystals

form

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Application

α-Ketoglutaric acid has been used:
  • as a supplement in minimum essential medium α (α-MEM) to culture primary mesenchymal stromal/stem cells (MSCs) to study its effects on age-related osteoporosis[1]
  • for chemical treatments to compare the treatment effects of several compounds on lifespan between manual and automated lifespan machine (ALM) platforms[2]
  • as a printed chemotaxis ligand to screen chemotaxis receptors with high-throughput technologies and verify the interactions with surface plasmon resonance (SPR)[3]

Biochem/physiol Actions

Alpha-ketoglutarate (αKG), a nitrogen scavenger, is an important source of glutamate and glutamine.[4] It controls the synthesis of ATP and decreases the generation of equivalent (NAD+/NADH) in the tricarboxylic acid (TCA) cycle.[1] It promotes the synthesis of protein and prevents protein degradation in muscles. This immune nutrient factor participates in the general immune and collagen metabolism.[4] In aged rodents, αKG accelerates the healing of bone defects. It may possess potential anti-aging effects.[1] This Krebs cycle molecule can be used as a supplement in insect and mammalian cell cultures.

General description

Alpha-ketoglutarate (αKG), a vital intermediate in the tricarboxylic acid (TCA)/Krebs cycle, is located between succinyl-CoA and isocitrate.[1]

pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H318

Hazard Classifications

Eye Dam. 1

Classe di stoccaggio

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
BCCM6132
0000271298
BCCK7215
0000271298
BCCH3270

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Nan Wu et al.
Biomolecules & therapeutics, 24(1), 1-8 (2016-01-14)
Alpha-ketoglutarate (AKG) is a key molecule in the Krebs cycle determining the overall rate of the citric acid cycle of the organism. It is a nitrogen scavenger and a source of glutamate and glutamine that stimulates protein synthesis and inhibits
Yuan Wang et al.
Nature communications, 11(1), 5596-5596 (2020-11-07)
Age-related osteoporosis is characterized by the deterioration in bone volume and strength, partly due to the dysfunction of bone marrow mesenchymal stromal/stem cells (MSCs) during aging. Alpha-ketoglutarate (αKG) is an essential intermediate in the tricarboxylic acid (TCA) cycle. Studies have
Kaiju Sun et al.
Theranostics, 11(12), 5831-5846 (2021-04-27)
Purpose: The implementation of targeted therapies for acute myeloid leukemia (AML) has been challenging. Fat mass and obesity associated protein (FTO), an mRNA N6-methyladenosine (m6A) demethylase, functions as an oncogene that promotes leukemic oncogene-mediated cell transformation and leukemogenesis. Here, we
J Kitaura et al.
European journal of pediatrics, 158(5), 410-413 (1999-05-20)
Two cases of hyperinsulinaemic hypoglycaemia associated with persistent hyperammonaemia in unrelated infants of 7 days and 4 months of age are reported. Blood ammonia levels were 100-300 micromol/l (normal values <40 micromol/l). The hyperammonaemia was asymptomatic and not associated with
Christopher J Day et al.
Methods in molecular biology (Clifton, N.J.), 1729, 303-317 (2018-02-13)
Ligand-receptor interactions triggering signal transduction components of many sensory pathways, remain elusive due to paucity of high-throughput screening methods. Here we describe our use of small molecule microarrays comprising of small glycans, amino and organic acids, salts, and other known
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