A 100 nM solution of this product requires 0.02565 mg dissolved in a final volume of 1 liter. The easiest method to prepare this solution involves first creating a more concentrated solution and then diluting it. A 1 mM solution of this product requires 25.642 mg dissolved in a final volume of 1 liter. 100 ?L of the more concentrated solution can be diluted to 1 liter with pure DMSO to achieve a final concentration of 100 nM. The amount of BSA added will depend on the desired final concentration of this component.
P5585
Palmitic acid
BioXtra, ≥99%
Sinonimo/i:
1-Pentadecanecarboxylic acid, C16:0, Cetylic acid, Hexadecanoic acid, NSC 5030, PamOH
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10 G
102,00 €
25 G
203,00 €
100 G
398,00 €
102,00 €
Per informazioni sulla disponibilità, contatta il Servizio Clienti.
Informazioni su questo articolo
Formula condensata:
CH3(CH2)14COOH
Numero CAS:
Peso molecolare:
256.42
MDL number:
UNSPSC Code:
12352106
NACRES:
NA.25
PubChem Substance ID:
EC Number:
200-312-9
Beilstein/REAXYS Number:
607489
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Permettici di aiutartiNome del prodotto
Palmitic acid, BioXtra, ≥99%
InChI
1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)
InChI key
IPCSVZSSVZVIGE-UHFFFAOYSA-N
SMILES string
CCCCCCCCCCCCCCCC(O)=O
biological source
plant (vegetable)
grade
BioPerformance Certified
vapor pressure
10 mmHg ( 210 °C)
product line
BioXtra
assay
≥99%
form
powder
technique(s)
cell culture | mammalian: suitable
impurities
≤0.0005% Phosphorus (P)
≤0.1% Insoluble matter
ign. residue
≤0.1%
bp
271.5 °C/100 mmHg (lit.)
mp
61-62.5 °C (lit.)
solubility
chloroform: 0.5 M, clear, colorless
density
0.852 g/mL at 25 °C (lit.)
anion traces
chloride (Cl-): ≤0.05%
sulfate (SO42-): ≤0.05%
cation traces
Al: ≤0.005%
Ca: ≤0.0005%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.005%
Mg: ≤0.0005%
NH4+: ≤0.05%
Na: ≤0.05%
Pb: ≤0.001%
Zn: ≤0.0005%
functional group
carboxylic acid
lipid type
saturated FAs
shipped in
ambient
storage temp.
room temp
Quality Level
Gene Information
human ... FABP2(2169), FABP3(2170), FABP4(2167), FABP5(2171)
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Categorie correlate
1 of 4
Questo articolo | W283207 | P0500 | W283215 |
|---|---|---|---|
| assay ≥99% | assay ≥98% | assay ≥99% | assay 98% |
| Quality Level 200 | Quality Level 400 | Quality Level 200 | Quality Level 400 |
| form powder | form solid | form powder | form crystals or chunks |
| solubility chloroform: 0.5 M, clear, colorless | solubility water: 0.00005 g/L at 20 °C | solubility - | solubility water: 0.00005 g/L at 20 °C |
| storage temp. room temp | storage temp. - | storage temp. room temp | storage temp. - |
| mp 61-62.5 °C (lit.) | mp 61-62.5 °C (lit.) | mp 61-62.5 °C (lit.) | mp 61-62.5 °C (lit.) |
Application
Biochem/physiol Actions
Palmitic acid (PA) is a component of membrane phospholipids (PL) and adipose triacylglycerols (TAG).[4] Elevated levels of palmitic acid contributes to the pathophysiology of atherosclerosis, type 2 diabetes mellitus, neurodegenerative diseases, obesity and cancer.[4][5] PA promotes apoptosis in the endothelial cell by modulating the p38 mitogen-activated protein kinase (MAPK) pathway and favors expression of TNF-α and reactive oxygen species accumulation.[6] PA promotes interleukin 8 (IL-8) synthesis in hepatocytes contributing to hepatic inflammation.[7] PA by interacting with toll-like receptor 4 (TLR4) induces inflammatory injury in cardiomyoctes.[8]
Palmitic acid is a straight-chain 16-carbon fatty acid. Diets rich in palmitic acid, along with lauric and myristic acids, are associated with increased serum levels of low-density lipoprotein cholesterol. Palmitic acid is the first fatty acid produced by lipogenesis. It is a negative regulator of acetyl-CoA carboxylase (ACC) and is implicated in fatty acid-induced insulin resistance.
Classe di stoccaggio
11 - Combustible Solids
wgk
nwg
flash_point_f
235.4 °F
flash_point_c
113 °C
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Articoli
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Lipid Induced Insulin Resistance
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I would like to know how to adjust this product to a final concentration of 100nM using DMSO and BSA.
1 risposta-
Utile?
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How can I determine the shelf life / expiration / retest date of this product?
1 risposta-
If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdfUtile?
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I want to know the storage temperature after reconstituting the product in the solvent? Also clarify regarding the type of solvent to be used?
1 risposta-
Unfortunately, the stability of this product in solution is not determined.
Utile?
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How is shipping temperature determined? And how is it related to the product storage temperature?
1 risposta-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
Utile?
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I am curious about the storage temperature of this product.
1 risposta-
As listed in the PROPERTIES section of the product page, this product may be stored at room temperature.
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Can you tell me the storage temperature for this product?
1 risposta-
As stated in the PROPERTIES section of the product page, this product is stored at room temperature.
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Is this product soluble only in chloroform? Did you know something about its solubility in ethanol or DMSO?
1 risposta-
Stock solutions of palmitic acid can be prepared in 200 proof ethanol or DMSO at 20 mg/mL. Stock solutions should be purged with inert gas, such as argon or nitrogen, prior to storage.
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