Salbutamol hemisulfate is not an anticholinergic. This compound is a β2-Adrenergic receptor agonist.
S5013
Salbutamol hemisulfate salt
≥98%
Sinonimo/i:
α-([t-Butylamino]methyl)-4-hydroxy-m-xylene-α,α′-diol, Albuterol
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25 MG
69,20 €
50 MG
114,00 €
100 MG
192,00 €
250 MG
300,00 €
69,20 €
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Informazioni su questo articolo
Formula condensata:
C13H21NO3 · 1/2H2SO4
Numero CAS:
Peso molecolare:
288.35
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
256-916-8
MDL number:
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Permettici di aiutartiNome del prodotto
Salbutamol hemisulfate salt, ≥98%
InChI
1S/2C13H21NO3.H2O4S/c2*1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15;1-5(2,3)4/h2*4-6,12,14-17H,7-8H2,1-3H3;(H2,1,2,3,4)
InChI key
BNPSSFBOAGDEEL-UHFFFAOYSA-N
SMILES string
OS(O)(=O)=O.CC(C)(C)NCC(O)c1ccc(O)c(CO)c1.CC(C)(C)NCC(O)c2ccc(O)c(CO)c2
assay
≥98%
solubility
1 M NaOH: 50 mg/ml, clear to slightly hazy, yellow-green
originator
GlaxoSmithKline
Quality Level
Gene Information
human ... ADRB2(154)
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Categorie correlate
1 of 4
Questo articolo | BP302 | PHR1053 | S0150000 |
|---|---|---|---|
| assay ≥98% | assay - | assay - | assay - |
| Quality Level 200 | Quality Level - | Quality Level 300 | Quality Level - |
| solubility 1 M NaOH: 50 mg/ml, clear to slightly hazy, yellow-green | solubility - | solubility - | solubility - |
| originator GlaxoSmithKline | originator - | originator - | originator - |
| Gene Information human ... ADRB2(154) | Gene Information human ... ADRB2(154) | Gene Information human ... ADRB2(154) | Gene Information human ... ADRB2(154) |
Application
Salbutamol hemisulfate salt has been used as reference standards of drugs for the validation of β-agonist residue.[1]
Salbutamol hemisulfate salt was used as standard in analysis of fortified meat for LABA content using ELISA kits.3 It was used to study the response of prostaglandin 2α to various β-adrenergic agonists in cultured bovine endometrial cells.4
Biochem/physiol Actions
β2-Adrenergic receptor agonist.
Salbutamol is a β2 adrenoceptor agonist with short acting bronchodilation and anti-inflammatory effects. It relaxes the airway smooth muscles and inhibits bronchoconstriction induced by adenosine-5′ -monophosphate (AMP). Salbutamol is particularly effective in treatment of asthma as it provides immediate relief. Salbutamol is one of the most popular short-acting BA (SABA). It is useful in treating the symptoms of EIB (exercise induced bronchospasm).[2]
Salbutamol is a β2 adrenoceptor agonist with short acting bronchodilation and anti-inflammatory effects. It relaxes the airway smooth muscles and inhibits bronchoconstriction induced by adenosine-5′ -monophosphate (AMP).1 Salbutamol is particularly effective in treatment of asthma as it provides immediate relief.2
Features and Benefits
This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
Hazard Classifications
Carc. 2 - Repr. 2 - Skin Sens. 1
Classe di stoccaggio
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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R S Pirie et al.
Journal of veterinary pharmacology and therapeutics, 40(3), 231-238 (2016-09-07)
Despite frequent use of metered dose inhalers (MDIs) and spacers in equine practice, limited information exists on the efficiency of aerosol delivery using such devices. We determined the particle size distribution within an MDI-generated salbutamol aerosol delivered via an equine
Validation of ELISA test kits for detection of beta-agonist residues in meat
Ponniah J, et al.
The Southeast Asian Journal of Tropical Medicine and Public Health, 35(1), 481-487 (2004)
Medical and pharmacological approach to adjust the salbutamol anti-doping policy in athletes
Pillard F, et al.
Respiratory Research, 16(1), 155-155 (2015)
B Padhukasahasram et al.
The pharmacogenomics journal, 14(4), 365-371 (2014-01-15)
Inhaled short-acting beta-agonist (SABA) medication is commonly used in asthma patients to rapidly reverse airway obstruction and improve acute symptoms. We performed a genome-wide association study of SABA medication response using gene-based association tests. A linear mixed model approach was
Ashley Woodcock et al.
Chest, 144(4), 1222-1229 (2013-07-13)
The combination of fluticasone furoate (FF), a novel inhaled corticosteroid (ICS), and vilanterol (VI), a long-acting β2 agonist, is under development as a once-daily treatment of asthma and COPD. The aim of this study was to compare the efficacy of
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is salbutamol an anticholinergic?
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