SML2561

ML162

Name: ML162
Brand: SIGMA
Price: 87.6 EUR

≥98% (HPLC), glutathione peroxidase inhibitor, powder

Sinonimo/i:

α-[(2-Chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thiopheneacetamide, 2-Chloro-N-(3-chloro-4-methoxyphenyl)-N-(2-oxo-2-(phenethylamino)-1-(thiophen-2-yl)ethyl)acetamide, BRD-5421, BRD5421, CID 3689413, ML 162, ML-162, Molecular Libraries 162

Slide 1 of 1

Autenticati per visualizzare i prezzi organizzativi e contrattuali.

Scegli un formato

5 MG

87,60 €

25 MG

299,20 €

87,60 €

Per informazioni sulla disponibilità, contatta il Servizio Clienti.

Richiedi un ordine in blocco

Informazioni su questo articolo

Formula empirica (notazione di Hill):

C₂₃H₂₂Cl₂N₂O₃S

Numero CAS:

1035072-16-2

Peso molecolare:

477.40

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD03450805

Documenti fondamentali

Visualizza tutta la documentazione

Vai a

Servizio Tecnico

Hai bisogno di aiuto? Il nostro team di scienziati qualificati è a tua disposizione.

Permettici di aiutarti

Nome del prodotto

ML162, ≥98% (HPLC)

SMILES string

[s]1c(ccc1)C(N(c3cc(c(cc3)OC)Cl)C(=O)CCl)C(=O)NCCc2ccccc2

InChI

1S/C23H22Cl2N2O3S/c1-30-19-10-9-17(14-18(19)25)27(21(28)15-24)22(20-8-5-13-31-20)23(29)26-12-11-16-6-3-2-4-7-16/h2-10,13-14,22H,11-12,15H2,1H3,(H,26,29)

InChI key

UNVKYJSNMVDZJE-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to very dark brown

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Categorie correlate

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

Confronta articoli simili

Visualizza il confronto per intero

Mostra le differenze

1 of 4

Questo articolo	SML0827	SML1901	SML1813
Sigma-Aldrich SML2561 ML162	Sigma-Aldrich SML0827 FPH1	Sigma-Aldrich SML1901 ML348	Sigma-Aldrich SML1813 Ani9
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form powder	form powder	form powder	form powder
storage temp. 2-8°C	storage temp. −20°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: 2 mg/mL, clear	solubility DMSO: 20 mg/mL, clear	solubility DMSO: 20 mg/mL, clear	solubility DMSO: 25 mg/mL, clear
color white to very dark brown	color white to beige	color white to beige	color white to beige

Biochem/physiol Actions

Covalent phospholipid glutathione peroxidase (GPX4; GSHPx-4; PHGPx; snGPx; snPHGPx) inhibitor that induces ferroptosis.

ML162 is a small molecule that induces ferroptosis via covalent inhibition of cellular phospholipid glutathione peroxidase (GPX-4; GPX4; GSHPx-4; PHGPx; snGPx; snPHGPx). Synthetic lethality studies in cancer cultures identify contributing factors such as HRas(G12V) expression and fumarate hydratase (FH) deletion to ML162 sensitivity (IC50 = 25 nM & 35 nM, respectively, in BJeLR-HRas(G12V) & UOK262-FH-/- cultures).

Classe di stoccaggio

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number

0000224211

0000167977

0000119328

Non trovi la versione di tuo interesse?

Se hai bisogno di una versione specifica, puoi cercare il certificato tramite il numero di lotto.

Cerca un COA

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

Cell-Line Selectivity Improves the Predictive Power of Pharmacogenomic Analyses and Helps Identify NADPH as Biomarker for Ferroptosis Sensitivity.

Kenichi Shimada et al.

Cell chemical biology, 23(2), 225-235 (2016-02-09)

Precision medicine in oncology requires not only identification of cancer-associated mutations but also effective drugs for each cancer genotype, which is still a largely unsolved problem. One approach for the latter challenge has been large-scale testing of small molecules in

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway.

Vasanthi S Viswanathan et al.

Nature, 547(7664), 453-457 (2017-07-06)

Plasticity of the cell state has been proposed to drive resistance to multiple classes of cancer therapies, thereby limiting their effectiveness. A high-mesenchymal cell state observed in human tumours and cancer cell lines has been associated with resistance to multiple

Ferroptosis Induction in Multiple Myeloma Cells Triggers DNA Methylation and Histone Modification Changes Associated with Cellular Senescence.

Emilie Logie et al.

International journal of molecular sciences, 22(22) (2021-11-28)

Disease relapse and therapy resistance remain key challenges in treating multiple myeloma. Underlying (epi-)mutational events can promote myelomagenesis and contribute to multi-drug and apoptosis resistance. Therefore, compounds inducing ferroptosis, a form of iron and lipid peroxidation-regulated cell death, are appealing

Development of small-molecule probes that selectively kill cells induced to express mutant RAS.

Michel Weïwer et al.

Bioorganic & medicinal chemistry letters, 22(4), 1822-1826 (2012-02-03)

Synthetic lethal screening is a chemical biology approach to identify small molecules that selectively kill oncogene-expressing cell lines with the goal of identifying pathways that provide specific targets against cancer cells. We performed a high-throughput screen of 303,282 compounds from

Copper-dependent autophagic degradation of GPX4 drives ferroptosis.

Qian Xue et al.

Autophagy, 19(7), 1982-1996 (2023-01-10)

Ferroptosis is a type of iron-dependent regulated cell death characterized by unrestricted lipid peroxidation and membrane damage. Although GPX4 (glutathione peroxidase 4) plays a master role in blocking ferroptosis by eliminating phospholipid hydroperoxides, the regulation of GPX4 remains poorly understood.

Visualizza tutti i documenti correlati

Domande

Recensioni

Nessuna valutazione

Filtri attivi

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica

ML162