196878-M

(±)-Bay K 8644

Synthetic dihydropyridine derivative that acts as an active Ca²⁺ slow channel agonist in neuroendocrine, muscle, thyroid and other cell types.

• 別名: (±)-Bay K 8644, 1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2ʹ-(trifluoromethyl)phenyl]-3-pyridinecarboxylic Acid Methyl Ester
• 実験式（ヒル表記法）: C₁₆H₁₅F₃N₂O₄
• 分子量: 356.30
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: yellow
• 溶解性: DMSO: 35 mg/mL; ethanol: 35 mg/mL
• 保管温度: 2-8°C

詳細

詳細

A synthetic dihydropyridine derivative that is an active Ca²⁺ slow channel agonist in neuroendocrine, muscle, thyroid, and other cell types. Prolongs single channel open time without affecting the close time. An L-type Ca²⁺ channel agonist. Composed of two optical isomers. The (-)-enantiomer has strong vasoconstrictive, positive ionotropic, and Ca²⁺ agonistic properties, whereas the (+)-enantiomer has weak vasodilating, negative ionotropic, and Ca²⁺ antagonistic properties. The net effect of the racemic mix is that of the negative enantiomer. Promotes β-cell proliferation/regeneration.

Synthetic dihydropyridine derivative that acts as an active Ca²⁺ slow channel agonist in neuroendocrine, muscle, thyroid and other cell types. Prolongs single channel open time without affecting the close time. An L-type Ca²⁺ channel agonist. Composed of two optical isomers. The (-)-enantiomer has strong vasoconstrictive, positive inotropic, and Ca²⁺ agonistic properties, whereas the (+)-enantiomer has weakly vasodilating, negative inotropic, and Ca²⁺ antagonistic properties. The net effect of the racemic mix is that of the negative enantiomer. Promotes β-cell proliferation/regeneration.

生物化学的／生理学的作用

Primary Target
L-type Ca2+ channel

調製ノート

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 20 days at 4°C.

その他情報

Wang, W., et al. 2009. Proc. Natl. Acad. Sci. USA106, 1427.
Weigl, L.G., et al. 2000. J. Physiol.525 (pt. 2), 461.
Vannier, C., et al. 1995. Am. J. Physiol. 268, L201.
Bechem, M., and Hoffmann, H. 1993. Pflugers Arch. 424, 343.
Triggle, D.J., and Rompe, D. 1989. Trends Pharmacol. Sci. 10, 507.
Takasu, N., et al. 1987. Biochem. Biophys. Res. Commun.143, 1107.
Tagliatela, M., et al. 1986. Brain Res.381, 356.
Franckowiak, G., et al. 1985. Eur. J. Pharmacol.114, 223.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免責事項

Toxicity: Irritant (B)

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable