Wee1 Inhibitor

Name: Wee1 Inhibitor
Brand: MM

≥97% (HPLC), solid

別名:

Wee1 Inhibitor, 4-(2-Chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3-(2H,6H)-dione, Chk1 Inhibitor V

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この商品について

実験式（ヒル表記法）:

C₂₀H₁₁ClN₂O₃

CAS番号:

622855-37-2

分子量:

362.77

MDL number:

MFCD28138102

UNSPSC Code:

12352200

NACRES:

NA.77

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製品名

Wee1 Inhibitor, The Wee1 Inhibitor, also referenced under CAS 622855-37-2, controls the biological activity of Wee1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

SMILES string

Clc1c(cccc1)c2c3c(c4c([nH]c5c4cc(cc5)O)c2)[c]([nH][c]3=O)=O

InChI

1S/C20H11ClN2O3/c21-13-4-2-1-3-10(13)11-8-15-16(18-17(11)19(25)23-20(18)26)12-7-9(24)5-6-14(12)22-15/h1-8,22,24H,(H,23,25,26)

InChI key

DPEXRCOBPACFOO-UHFFFAOYSA-N

assay

≥97% (HPLC)

form

solid

potency

11 nM IC₅₀

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
protect from light

color

light orange

solubility

DMSO: 10 mg/mL
ethanol: 10 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

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当該品目	681641	528282	217714
Sigma-Aldrich 681640 Wee1 Inhibitor	Sigma-Aldrich 681641 Wee1 Inhibitor II	Sigma-Aldrich 528282 Polo-like Kinase Inhibitor I	Sigma-Aldrich 217714 Cdk1/2 Inhibitor III
assay ≥97% (HPLC)	assay ≥97% (HPLC)	assay ≥98% (HPLC)	assay ≥95% (HPLC)
form solid	form solid	form solid	form solid
manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. −20°C	storage temp. −20°C	storage temp. 2-8°C	storage temp. 2-8°C
storage condition OK to freeze, protect from light	storage condition OK to freeze, protect from light	storage condition OK to freeze, protect from light	storage condition OK to freeze, protect from light

Biochem/physiol Actions

Cell permeable: no

Product competes with ATP.

Reversible: no

Disclaimer

Toxicity: Standard Handling (A)

General description

A pyrrolocarbazole compound that acts as a potent, ATP-binding site-targeting inhibitor of Wee1 (IC₅₀ = 11 nM) in an ATP-competitive manner and displays ~40-fold selectivity over the related checkpoint kinase Chk1 (IC₅₀ = 440 nM).

Packaging

Packaged under inert gas

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

保管分類

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c