AB2202
Anti-PER2 Antibody
serum, Chemicon®
別名:
Anti-FASPS, Anti-FASPS1
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この商品について
UNSPSCコード:
12352203
eCl@ss:
32160702
NACRES:
NA.41
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由来生物
rabbit
品質水準
結合体
unconjugated
抗体製品の状態
serum
抗体製品タイプ
primary antibodies
クローン
polyclonal
交差性
mouse, rat
メーカー／製品名
Chemicon®
テクニック
western blot: suitable
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
ターゲットの翻訳後修飾
unmodified
遺伝子情報
mouse ... Per2(18627)
関連するカテゴリー
1 of 4
当該品目 | AB5428P | AB2201 | WH0008864M1 |
|---|---|---|---|
| biological source rabbit | biological source rabbit | biological source rabbit | biological source mouse |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| antibody form serum | antibody form affinity purified immunoglobulin | antibody form serum | antibody form purified immunoglobulin |
| shipped in wet ice | shipped in dry ice | shipped in wet ice | shipped in dry ice |
| technique(s) western blot: suitable | technique(s) ELISA: suitable, western blot: suitable | technique(s) western blot: suitable | technique(s) immunofluorescence: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, indirect ELISA: suitable, western blot: 1-5 μg/mL |
| Gene Information mouse ... Per2(18627) | Gene Information mouse ... Per2(18627) | Gene Information mouse ... Per1(18626) | Gene Information human ... PER2(8864) |
詳細
Approx. 136 kDa Band may be observed at a much higher 200 kDa by the liver product depending on level of phophorylation and gel system used.
PER2 is a component of the circadian clock mechanism which is essential for generating circadian rhythms. It is a negative element in the circadian transcriptional loop by Influencing clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. PER2 negatively regulates CLOCK NPAS2-BMAL1 BMAL2-induced transactivation. This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known.
免疫原
Synthetic peptide.
アプリケーション
Research Category
ニューロサイエンス
ニューロサイエンス
Research Sub Category
サーカディアンリズム及び睡眠
サーカディアンリズム及び睡眠
Anti-PER2 Antibody detects level of PER2 & has been published & validated for use in WB.
Western Blot Analysis:
C2C12 lysate was resolved by electrophoresis, transferred to PVDF membrane and probed with anti-PER2 (1:500 dilution of this lot). Proteins were visualized using a Donkey anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence detection system.
C2C12 lysate was resolved by electrophoresis, transferred to PVDF membrane and probed with anti-PER2 (1:500 dilution of this lot). Proteins were visualized using a Donkey anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence detection system.
生物化学的／生理学的作用
Cat. # AB2202 will recognize the N-terminus of PER2.
Reactivity with other species has not been determined.
物理的形状
Serum with 0.05% NaN3
調製ノート
Maintain at -20°C in undiluted aliquots for up to 1 year after date of receipt.
アナリシスノート
Control
C2C12 tissue lysate.
C2C12 tissue lysate.
Routinely evaluated by western blot on C2C12 lysate.
その他情報
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
法的情報
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 1
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
AB2202:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Peiyuan Qiu et al.
National science review, 6(1), 87-100 (2019-01-01)
Circadian disruption is a risk factor for metabolic, psychiatric and age-related disorders, and non-human primate models could help to develop therapeutic treatments. Here, we report the generation of BMAL1 knockout cynomolgus monkeys for circadian-related disorders by CRISPR/Cas9 editing of monkey
Shell neurons of the master circadian clock coordinate the phase of tissue clocks throughout the brain and body.
Evans, JA; Suen, TC; Callif, BL; Mitchell, AS; Castanon-Cervantes, O; Baker, KM; Kloehn et al.
BMC Biology null
Youli Yao et al.
Frontiers in physiology, 11, 294-294 (2020-05-12)
Alzheimer's disease (AD) patients often exhibit perturbed circadian rhythm with fragmented sleep before disease onset. This study was designed to evaluate the effect of a 40-Hz light flicker on circadian rhythm in an AD mouse model (APP/PS1). Locomotor rhythms recordings
Jennifer Gile et al.
Current pharmaceutical design, 26(34), 4330-4337 (2020-04-16)
We recently reported a role for the circadian rhythm protein Period 2 (PER2) in midazolam induced cognitive dysfunction. Based on previous studies showing a critical role for the adenosine A2B receptor (ADORA2B) in PER2 regulation, we hypothesized that hippocampal ADORA2B
Lamis Saad et al.
Genes, 12(8) (2021-08-28)
The circadian system interacts with the mesocorticolimbic reward system to modulate reward and memory in a time-of-day dependent manner. The circadian discrimination of reward, however, remains difficult to address between natural reinforcers and drugs of abuse. Circadian rhythms control cocaine
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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