MABF41

Anti-Interleukin-6 (IL-6) Antibody, clone 1G3

clone AB42_51.38C8.1G3, from mouse

• 別名: interleukin 6 (interferon, beta 2), IFN-beta-2, B-cell stimulatory factor 2, interleukin-6, Interferon beta-2, B cell stimulatory factor-2, Hybridoma growth factor, B-cell differentiation factor, CTL differentiation factor, interleukin BSF-2
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: mouse
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: purified immunoglobulin
• クローン: AB42_51.38C8.1G3, monoclonal
• 交差性: human
• テクニック: western blot: suitable
• アイソタイプ: IgG2bκ
• NCBIアクセッション番号: NP_000591
• UniProtアクセッション番号: P05231
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified

詳細

詳細

Interleukin-6 (IL-6) is a pro-inflammatory cytokine that seems to be involved in the late stages of CTL generation. Other biological functions also include amplification and the inflammatory response. Combination therapies including IL-6 have been shown to have positive effects on specific malignant tumor types. The accumulation of IL-6 in the CNS is usually detrimental and can contribute to pathology of CNS diseases. IL-6 signaling is negatively regulated by TGF-beta, which down regulates STAT1, STAT3 and ICAM-1 expression. IL-6 expression has been linked to inflammatory bowel disease (IBD) and is also the primary clinical target for IBD. Clinical use of an antibody for the IL-6 receptor (IL-6R) has been promising in treating rheumatoid arthritis, systemic juvenile idiopathic arthritis and Castleman’s disease.

~21 kDa observed

免疫原

Human IL-6 fused to the soluble domain of the IL-6R.

アプリケーション

Research Category
炎症及び免疫

Research Sub Category
サイトカイン及びサイトカイン受容体

Anti-Interleukin-6 (IL-6) Antibody, clone 1G3 is an antibody against Interleukin-6 (IL-6) for use in WB.

物理的形状

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

調製ノート

Stable for 1 year at 2-8°C from date of receipt.

アナリシスノート

Control
Human IL-6 recombinant protein

Evaluated by Western Blot with human IL-6 recombinant protein.

Western Blot Analysis: 0.5 g/mL of this antibody detected 10 g of human IL-6 recombinant protein.

その他情報

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Replaces: 04-1095

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable