We have not tested the cell membrane permeability of Product 90790, L-α-Hydroxyglutaric acid disodium salt. A helpful reference discussing the use of L-α-Hydroxyglutaric acid disodium salt to treat zebrafish is listed below.Parng, C. et al., Neurotoxicology and Teratology, 28, 509-516 , (2006).
90790
L-α-ヒドロキシグルタル酸 二ナトリウム塩
≥98.0% (GC)
別名:
(S)-2-ヒドロキシペンタン二酸 二ナトリウム塩, 二ナトリウム (S)-2-ヒドロキシグルタラート
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この商品について
化学式:
C5H6O5Na2
CAS番号:
分子量:
192.08
UNSPSC Code:
12352106
NACRES:
NA.32
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
5318042
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製品名
L-α-ヒドロキシグルタル酸 二ナトリウム塩, ≥98.0% (GC)
SMILES string
[O-]C(CC[C@@H](C([O-])=O)O)=O.[Na+].[Na+]
InChI key
DZHFTEDSQFPDPP-QTNFYWBSSA-L
InChI
1S/C5H8O5.2Na/c6-3(5(9)10)1-2-4(7)8;;/h3,6H,1-2H2,(H,7,8)(H,9,10);;/q;2*+1/p-2/t3-;;/m0../s1
assay
≥98.0% (GC)
form
powder or crystals
optical activity
[α]/D -8.5±1.5°, c = 1 in 0.1 M NaOH
impurities
≤6.0% water
relevant disease(s)
cancer
storage temp.
2-8°C
Quality Level
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関連するカテゴリー
1 of 4
当該品目 | H8378 | 94577 | 16859 |
|---|---|---|---|
| assay ≥98.0% (GC) | assay ≥95% (GC) | assay ≥95.0% (GC) | assay ≥98.0% (GC) |
| Quality Level 100 | Quality Level 200 | Quality Level 100 | Quality Level 100 |
| form powder or crystals | form powder | form powder or crystals | form powder or crystals |
| storage temp. 2-8°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C |
| optical activity [α]/D -8.5±1.5°, c = 1 in 0.1 M NaOH | optical activity - | optical activity - | optical activity [α]/D 8.5±1.5°, c = 1 in NaOH |
| impurities ≤6.0% water | impurities - | impurities ≤6.0% water | impurities ≤6.0% water |
Application
Biochem/physiol Actions
L-アルファ-ヒドロキシグルタル酸は、L-2-HGデヒドロゲナーゼのまれな欠陥の結果として蓄積し、代謝障害であるL-2-ヒドロキシグルタル酸尿症（L-2HGA）をもたらします。 L-2HGAは、ニューロンの欠陥、白質ジストロフィーと関連しており、脳腫瘍のリスク増加に関連しています。
General description
Packaging
底の開いたガラス瓶内容物は内部に挿入され接着された円錐部に入っています。
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Hugh Colvin et al.
Scientific reports, 6, 36289-36289 (2016-11-09)
Deranged metabolism is a hallmark of cancer, playing a significant role in driving the disease process. One such example is the induction of carcinogenesis by the oncometabolite D-2 hydroxyglutarate (D-2HG), which is produced by the mutated enzyme isocitrate dehydrogenase (IDH)
Rapid separation of some common intermediates of microbial metabolism by thin-layer chromatography.
A S Bleiweis et al.
Analytical biochemistry, 20(2), 335-338 (1967-08-01)
A S Bleiweis et al.
Journal of bacteriology, 94(5), 1560-1564 (1967-11-01)
Aspergillus glaucus, cultured on sodium propionate-mineral salts medium, incorporates (14)C-glyoxylate into labeled alpha-hydroxyglutaric acid within 30 sec. Mycelial extracts retain this biosynthetic capacity, which is destroyed by heating. Propionyl-2-(14)C-coenzyme A also in incorporated into labeled alpha-hydroxyglutaric acid by these mycelial
The production of alpha-hydroxyglutaric acid from glutamic acid by cell-free preparations of Peptococcus aerogenes.
W M Johnson et al.
Canadian journal of biochemistry, 47(12), 1103-1107 (1969-12-01)
Xudong Fu et al.
Cell metabolism, 22(3), 508-515 (2015-07-21)
We discovered recently that the central metabolite α-ketoglutarate (α-KG) extends the lifespan of C. elegans through inhibition of ATP synthase and TOR signaling. Here we find, unexpectedly, that (R)-2-hydroxyglutarate ((R)-2HG), an oncometabolite that interferes with various α-KG-mediated processes, similarly extends
プロトコル
We describe here a rapid and sensitive method to separate and measure D-2-OHG and L-2-OHG enantiomers using high-resolution mass spectrometry (HRMS) detection.
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Is Product 90790, L-α-Hydroxyglutaric acid disodium salt cell membrane permeable?
1 回答-
役に立ちましたか？
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What is the Department of Transportation shipping information for this product?
1 回答-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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