SML1085
Retro-2
≥98% (HPLC), endosome-to-Golgi retrograde transport inhibitor, powder
別名:
2,3-Dihydro-2-(5-methyl-2-thienyl)-3-phenyl-4(1H)-quinazolinone
ログインで組織・契約価格をご覧ください。
この商品について
実験式（ヒル表記法）:
C19H16N2OS
CAS番号:
分子量:
320.41
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
スキップする
製品名
Retro-2, ≥98% (HPLC)
SMILES string
O=C1C2=CC=CC=C2NC(C3=CC=C(C)S3)N1C4=CC=CC=C4
InChI
1S/C19H16N2OS/c1-13-11-12-17(23-13)18-20-16-10-6-5-9-15(16)19(22)21(18)14-7-3-2-4-8-14/h2-12,18,20H,1H3
InChI key
BOAPXDSRULBILC-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 10 mg/mL, clear (warmed)
storage temp.
2-8°C
Quality Level
1 of 4
当該品目 | SML1184 | SML0140 | L2545 |
|---|---|---|---|
| form powder | form powder | form powder | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. room temp | storage temp. 2-8°C |
| solubility DMSO: 10 mg/mL, clear (warmed) | solubility DMSO: 5 mg/mL, clear (warmed) | solubility DMSO: >5 mg/mL | solubility DMSO: >20 mg/mL |
| color white to beige | color white to beige | color white to off-white | color off-white |
Application
Retro-2 has been used to estimate retrograde trafficking of Shiga toxin subunit B (STxB)-Cy3.[1]
Biochem/physiol Actions
Retro-2 is a non-toxic inhibitor of the endosome-to-Golgi retrograde transport that selectively protect cells from ricin, cholera toxin, and Shiga-like toxins, without affecting compartment morphology, endogenous retrograde cargos, or other trafficking steps.
Retro-2 is a non-toxic inhibitor of the endosome-to-Golgi retrograde transport.
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Zhouguang Jiao et al.
Journal of applied toxicology : JAT, 40(10), 1440-1450 (2020-06-01)
The current study explores the detoxification effect of Retro-2 on ricin toxin (RT) cytotoxicity, as well as the mechanisms underlying such effects, to provide a basis for follow-up clinical applications of Retro-2. The mouse-derived mononuclear/macrophage cell line, RAW264.7, was used
Structural insights into Legionella RidL-Vps29 retromer subunit interaction reveal displacement of the regulator TBC1D5.
Barlocher K, et al.
Nature Communications, 8(1), 1543-1543 (2017)
Giulia Tebaldi et al.
Journal of virology, 94(24) (2020-10-09)
Herpes simplex virus 1 (HSV-1) causes significant morbidity and mortality in humans worldwide. HSV-1 enters epithelial cells via an endocytosis mechanism that is low-pH dependent. However, the precise intracellular pathway has not been identified, including the compartment where fusion occurs.
Sandrine Cojean et al.
PLoS neglected tropical diseases, 14(7), e0008396-e0008396 (2020-07-30)
The parasitophorous vacuoles (PVs) that insulate Leishmania spp. in host macrophages are vacuolar compartments wherein promastigote forms differentiate into amastigote that are the replicative form of the parasite and are also more resistant to host responses. We revisited the biogenesis
アクティブなフィルタ
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
製品に関するお問い合わせはこちら（テクニカルサービス）