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27285

Sigma-Aldrich

Ethylenediaminetetraacetic acid disodium salt dihydrate

meets analytical specification of Ph. Eur., BP, USP, FCC, 99.0-101.0%

Sinónimos:
Edetate disodium salt dihydrate, Disodium ethylenediaminetetraacetate dihydrate, EDTA disodium salt, Edathamil, EDTA-Na2, Sequestrene Na2
Empirical Formula (Hill Notation):
C10H14N2Na2O8 · 2H2O
Número de CAS:
Peso molecular:
372.24
Beilstein:
3900609
EC Number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

Agency/Method

tested according to BP
tested according to Ph. Eur.
tested according to USP

reg. compliance

tested according to FCC

assay

99.0-101.0%

quality

meets analytical specification of Ph. Eur., BP, USP, FCC

impurities

residual solvents, complies
≤0.001% cyanide (CN)
≤0.001% heavy metals (as Pb)
≤0.1% nitrilotriacetic acid (HPLC) (HPLC)

loss

8.7-11.4% loss on drying, 200 °C, 3 h

pH

4-5 (20 °C, 5%)

mp

248 °C (dec.) (lit.)

solubility

water: soluble 100 g/L at 20 °C

anion traces

chloride (Cl-): ≤100 mg/kg
sulfate (SO42-): ≤500 mg/kg

cation traces

As: ≤1 mg/kg
Ca:, in accordance
Fe: ≤10 mg/kg
Pb: ≤10 mg/kg

Featured Industry

Pharmaceutical (small molecule)

SMILES string

O.O.O.O.[Na+].[Na+].[Na+].[Na+].OC(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC(O)=O.OC(=O)CN(CCN(CC(O)=O)CC([O-])=O)CC([O-])=O

InChI

1S/C10H16N2O8.2Na.2H2O/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;2*1H2/q;2*+1;;/p-2

InChI key

OVBJJZOQPCKUOR-UHFFFAOYSA-L

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Application

Ethylenediaminetetraacetic acid disodium salt dihydrate has been used along with Na2HPO4 and citric acid for preparing Na2EDTA-McIlvaine buffer. Aqueous solution of Ethylenediaminetetraacetic acid disodium salt dihydrate has also been used for photocatalytic hydrogen production
Chelator of divalent cations. Inhibits enzymes, such as metalloproteases, that require divalent cations for activity.

Biochem/physiol Actions

Ethylenediaminetetraacetic acid disodium salt dihydrate is a widely used chelator of divalent cations like Ca+2 and inhibits metal ion-dependent proteases such as calcium-dependent cysteine proteases. EDTA also acts as a chelator of the zinc ion in the active site of metalloproteases; thus it inhibits metalloproteases that requires zinc for activity. Additionally, EDTA prevents platelet aggregation and is a preferred anticoagulant for platelet counts.

pictograms

Exclamation markHealth hazard

signalword

Warning

Hazard Classifications

Acute Tox. 4 Inhalation - Aquatic Chronic 3 - STOT RE 2 Inhalation

Target Organs

Respiratory Tract

Storage Class Code

11 - Combustible Solids

WGK Germany

WGK 2

Flash Point F

Not applicable

Flash Point C

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificado de Análisis

Certificado de origen

Evaluation of EDTA as the chelator in the biuret reagent.
H Van Kley et al.
Clinical chemistry, 19(6), 621-623 (1973-06-01)
Haruthai Sangjarusvichai et al.
Talanta, 79(4), 1036-1041 (2009-07-21)
In this report, we aimed to extend our previous efforts toward the evaluation of sulfonamides (SAs) with a boron-doped diamond (BDD) electrode. We improved this method by reducing the analysis time using a monolithic column coupled with amperometric detection to...
Solvent-free hydrothermal synthesis of anatase TiO2nanoparticleswith enhanced photocatalytic hydrogen production activity.
Ayad F. Alkaim
Applied Catalysis A: General, 466, 32- 37 (2013)
Sinan Akbayram et al.
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 17(5), 494-496 (2010-06-10)
Ethylenediaminetetraacetic acid (EDTA)-dependent pseudothrombocytopenia (PTCP) is the phenomenon of a spurious low platelet count due to antiplatelet antibodies that cause platelet clumping in blood anticoagulated with EDTA. The aggregation of platelets in EDTA-dependent PTCP is usually prevented by other anticoagulants...
Suli Huang et al.
PloS one, 10(2), e0117007-e0117007 (2015-02-07)
microRNA (miRNA) plays a role in the pathogenesis of ischemic stroke, and single nucleotide polymorphisms in miRNA genes may contribute to disease susceptibility. However, the effect of miR-146a, miR-196a2, and miR-499 polymorphisms on ischemic stroke susceptibility has been rarely reported....

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