D3876

2′-Deoxyuridine 5′-monophosphate disodium salt

≥98% (HPLC), synthetic (organic), powder

• Synonim(y): dUMP
• Wzór liniowy: C₉H₁₁N₂O₈PNa₂
• Numer CAS: 42155-08-8
• Masa cząsteczkowa: 352.15
• NACRES: NA.51
• PubChem Substance ID: 24893787
• UNSPSC Code: 41106305
• EC Number: 255-687-1
• MDL number: MFCD00065282
• Assay: ≥98% (HPLC)
• Biological source: synthetic (organic)
• Form: powder
• Solubility: water: 50 mg/mL, clear, colorless
• Storage temp.: −20°C

Właściwości

• Nazwa produktu: 2′-Deoxyuridine 5′-monophosphate disodium salt, Sigma Grade
• biological source: synthetic (organic)
• Quality Segment: 200
• grade: Sigma Grade
• assay: ≥98% (HPLC)
• form: powder
• solubility: water: 50 mg/mL, clear, colorless
• storage temp.: −20°C
• SMILES string: [Na].OC1CC(OC1COP(O)(O)=O)N2C=CC(=O)NC2=O
• InChI: 1S/C9H13N2O8P.Na.H/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17;;/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17);;
• InChI key: WXIVKKBDJOCRNB-UHFFFAOYSA-N

Opis

General description

2′-Deoxyuridine 5′-monophosphate disodium salt (dUMP) is a substrate for thymidylate synthase and is converted to deoxythymidine monophosphate (dTMP).

Application

2′-Deoxyuridine 5′-monophosphate disodium salt has been used:

• in ultraperformance liquid chromatography-tandem mass spectrometry (UPLC/MS/MS) assay
• to stimulate proliferation of peripheral blood mononuclear cell (PBMCs) exposed to influenza virus antigen
• in thymidylate synthase activity assay Helicobacter pylori

2′-Deoxyuridine 5′-monophosphate (dUMP) is used by the enzyme thymidylate synthetase (TS) (EC 2.1.1.45) for the de novo production of dTMP. dUMP is used as the reference substrate in studies of dUMP analogues in potential chemotherapy applications.

Biochem/physiol Actions

2′-Deoxyuridine 5′-monophosphate disodium salt (dUMP) conversion to pyrimidine is inhibited by methotrexate. The inhibition of dUMP to deoxythymidine monophosphate (dTMP) at the methylation step is a key in controlling bacterial and eukaryotic cell growth.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Słowo ostrzegawcze: Warning
• Kody zagrożeń: H302,H315,H319,H335
• Ostrzeżenia: P261 - P264 - P271 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Narządy docelowe: Respiratory system
• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): dust mask type N95 (US), Eyeshields, Gloves