I9532

Icilin

≥97% (HPLC), CMR1 receptor agonist, solid

• Synonym(s): 1-(2-Hydroxyphenyl)-4-(3-nitrophenyl)-1,2,3,6-tetra­hydro­pyrimidin-2-one, AG-3-5
• Empirical Formula (Hill Notation): C₁₆H₁₃N₃O₄
• CAS Number: 36945-98-9
• Molecular Weight: 311.29
• UNSPSC Code: 12352200
• PubChem Substance ID: 24277906
• NACRES: NA.77
• MDL number: MFCD01689072
• eCl@ss: 32160701
• Assay: ≥97% (HPLC)
• Form: solid

Properties

• Product Name: Icilin, ≥97% (HPLC), solid
• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: solid
• color: yellow
• solubility: DMSO: 15 mg/mL
• SMILES string: Oc1ccccc1N2CC=C(NC2=O)c3cccc(c3)[N+]([O-])=O
• InChI: 1S/C16H13N3O4/c20-15-7-2-1-6-14(15)18-9-8-13(17-16(18)21)11-4-3-5-12(10-11)19(22)23/h1-8,10,20H,9H2,(H,17,21)
• InChI key: RCEFMOGVOYEGJN-UHFFFAOYSA-N

Description

General description

Icilin is a synthetic cooling agent and modulates human transient receptor potential cation channel (TRPA1). Icilin inhibits transient receptor potential cation channel subfamily M member 8 (TRPM8) and modulates calcium release. Icilin also suppresses transient receptor potential vanilloid subtype 3 (TRPV3).

Application

Icilin has been used as cooling agent in anterior ventromedial preoptic area (VMPO) neurons.

Biochem/physiol Actions

Icilin is a potent agonist at the CMR1 cold- and menthol-sensitive receptor.

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): dust mask type N95 (US), Eyeshields, Gloves