Each vial contains 50 mg.
等級
pharmaceutical primary standard
API 家族
busulfan
製造商／商標名
EDQM
mp
114-117 °C (lit.)
應用
pharmaceutical (small molecule)
形式
neat
SMILES 字串
CS(=O)(=O)OCCCCOS(C)(=O)=O
InChI
1S/C6H14O6S2/c1-13(7,8)11-5-3-4-6-12-14(2,9)10/h3-6H2,1-2H3
InChI 密鑰
COVZYZSDYWQREU-UHFFFAOYSA-N
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本產品 | BP403 | B2635 | I0086000 |
|---|---|---|---|
| manufacturer/tradename EDQM | manufacturer/tradename BP | manufacturer/tradename - | manufacturer/tradename EDQM |
| grade pharmaceutical primary standard | grade pharmaceutical primary standard | grade analytical standard, for drug analysis | grade pharmaceutical primary standard |
| application(s) pharmaceutical (small molecule) | application(s) pharmaceutical | application(s) forensics and toxicology | application(s) pharmaceutical (small molecule) |
| format neat | format neat | format neat | format neat |
| API family busulfan | API family busulfan | API family - | API family imidazole |
| mp 114-117 °C (lit.) | mp 114-117 °C (lit.) | mp 114-117 °C (lit.) | mp 88-91 °C (lit.) |
訊號詞
Danger
危險分類
Acute Tox. 3 Oral - Carc. 1A - Muta. 1B - Repr. 1B
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Ibrahim El-Serafi et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 913-914, 98-105 (2013-01-05)
Busulphan is an alkylating agent used as conditioning regimen prior to stem cell transplantation. Busulphan is metabolized in the liver and four major metabolites have been identified. The first metabolite is tetrahydrothiophene which is oxidized to tetrahydrothiophene 1-oxide, then sulfolane
M Hassan et al.
Leukemia & lymphoma, 22(5-6), 395-407 (1996-08-01)
Busulfan as a high-dose therapy is an important component of many of the myeloablative regimens for both allogeneic and autologous bone marrow transplantation (BMT) in adults and children. During the last decade, several studies have shown a wide inter- and
J A Russell et al.
Current pharmaceutical design, 14(20), 1936-1949 (2008-08-12)
Busulfan is the only agent used in myeloablative regimens for hematopoietic stem cell transplantation for which therapeutic drug monitoring (TDM) has been widely used. Studies of oral busulfan (Bu) indicate wide intrapatient and interpatient variations in pharmacokinetic (PK) behavior, particularly
Dharma Choudhary et al.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 19(3), 492-495 (2012-11-20)
Hematopoietic stem cell transplantation (HSCT) is the definite treatment for patients with thalassemia major. A busulfan (Bu) and cyclophosphamide (Cy)-based regimen has been the standard myeloablative chemotherapy, but it is associated with higher treatment-related toxicity, particularly in patients classified as
Moustapha Hassan et al.
Pharmacogenomics, 14(1), 75-87 (2012-12-21)
Hematopoietic stem cell transplantation (HSCT) is a curative treatment for several malignant and nonmalignant disorders. Busulfan (Bu) and cyclophosphamide (Cy) are the most commonly used alkylators in high-dose pretransplant conditioning for HSCT; a treatment that is correlated with drug-related toxicity
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