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Merck

E0774

红霉素

meets USP testing specifications

同義詞:

Erythromycin A

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經驗公式（希爾表示法）:
C37H67NO13
CAS 編號:
114-07-8
分子量：:
733.93
Beilstein:
75279
EC號碼:
204-040-1
MDL號碼:
MFCD00084654
分類程式碼代碼:
51282304
PubChem物質ID:
24894374
NACRES:
NA.76

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agency

USP/NF
meets USP testing specifications

品質等級

200

形狀

solid

光學活性

[α]/D -78 to --71°

溶解度

ethanol: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

抗生素活性譜

Gram-negative bacteria
Gram-positive bacteria

應用

pharmaceutical (small molecule)

作用方式

protein synthesis | interferes

SMILES 字串

CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O

InChI

1S/C37H67NO13/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1

InChI 密鑰

ULGZDMOVFRHVEP-RWJQBGPGSA-N

基因資訊

human ... ABCB1(5243), CYP3A4(1576), MLNR(2862)
mouse ... Abcb1a(18671), Abcb1b(18669)

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本產品
45674E6376E5389
红霉素 meets USP testing specifications

Sigma-Aldrich

E0774

红霉素

红霉素 tested according to Ph. Eur.

Sigma-Aldrich

45674

红霉素

红霉素 potency: ≥850 μg per mg

Sigma-Aldrich

E6376

红霉素

红霉素 BioReagent, suitable for cell culture

Sigma-Aldrich

E5389

红霉素

mode of action

protein synthesis | interferes

mode of action

protein synthesis | interferes

mode of action

protein synthesis | interferes

mode of action

protein synthesis | interferes

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

application(s)

pharmaceutical (small molecule)

application(s)

environmental

application(s)

-

application(s)

-

form

solid

form

solid

form

powder

form

powder

solubility

ethanol: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

solubility

H2O: soluble 2 mg/mL, acetone: freely soluble, acetonitrile: freely soluble, alcohol: soluble, amyl acetate: moderately soluble, chloroform: soluble, diethyl ether: soluble, ethyl acetate: freely soluble

solubility

ethanol: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

solubility

2 M HCl: 50 mg/mL (Stock solutions should be stored at 2-8 °C. Stable at 37 °C for 3 days.), ethanol: soluble (Stock solutions should be stored at 2-8 °C. Stable at 37 °C for 3 days.)

一般說明

化学结构：大环内酯

應用

红霉素是一种抗生素，是通过 红霉素链霉菌的某些菌株的生长而产生的。 该产品主要由红霉素A和少量红霉素B和C组成，推荐浓度为100 mg/L。 50至200mg/L的浓度范围也被证明可有效控制细菌的生长。 红霉素已被用作胃动素受体激动剂，以在体外阻断人气道中的呼吸糖结合物分泌， 并可用于质粒固化重组乳酸链球菌MG1363菌株的选择。

生化／生理作用

作用机制: 红霉素通过在转肽步骤中抑制延伸起作用，特别是通过结合细菌70S rRNA复合物的50S亚单位来抑制氨酰从A位点到P位点的易位。

抗菌谱：该产品可以抗革兰氏阴性和革兰氏阳性细菌。

準備報告

该产品可以2mg/mL的浓度溶于水中，0.067％的水溶液的pH值为8.0-10.5。 它也可以50mg/mL的浓度溶于乙醇中，获得澄清、无色至淡黄色的溶液。 它易溶于醇、丙酮、氯仿、乙腈和乙酸乙酯中，但会与酸形成盐。 所有溶液应保证避光。

免責聲明

该产品在37℃下在溶液中可保持稳定3天。 储备溶液应储存在2-8℃。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

從最近期的版本中選擇一個：

分析證明 (COA)

Lot/Batch Number
WXBF5376V
WXBD8720V
WXBD6913V
WXBD5402V
WXBD5192V

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Shrameeta Shinde et al.
Antibiotics (Basel, Switzerland), 10(2) (2021-01-27)
Biofilm, a stress-induced physiological state, is an established means of antimicrobial tolerance. A perpetual increase in multidrug resistant (MDR) infections associated with high mortality and morbidity have been observed in healthcare settings. Multiple studies have indicated that the use of
Saurabh Bhattacharya et al.
Cell reports, 27(2), 334-342 (2019-04-02)
We have previously described the existence of membranous nanotubes, bridging adjacent bacteria, facilitating intercellular trafficking of nutrients, cytoplasmic proteins, and even plasmids, yet components enabling their biogenesis remain elusive. Here we reveal the identity of a molecular apparatus providing a
Christoph Czarnetzki et al.
JAMA surgery, 150(8), 730-737 (2015-06-18)
Patients undergoing emergency procedures under general anesthesia have impaired gastric emptying and are at high risk for aspiration of gastric contents. Erythromycin has strong gastric prokinetic properties. To evaluate the efficacy of erythromycin lactobionate in gastric emptying in patients undergoing
Anna C Shore et al.
Antimicrobial agents and chemotherapy, 54(12), 4978-4984 (2010-10-06)
The staphylococcal cfr gene mediates resistance to phenicols, lincosamides, oxazolidinones, pleuromutilins, and streptogramin A, a phenotype that has been termed PhLOPS(A). The cfr gene has mainly been associated with coagulase-negative staphylococcal isolates from animals, and only a few cfr-positive methicillin-resistant
Leena Keurulainen et al.
Journal of medicinal chemistry, 53(21), 7664-7674 (2010-10-12)
Chlamydia pneumoniae is an intracellular bacterium that responds poorly to antibiotic treatment. Insufficient antibiotic usage leads to chronic infection, which is linked to disease processes of asthma, atherosclerosis, and Alzheimer's disease. The Chlamydia research lacks genetic tools exploited by other
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