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Merck

CYP3A4

cytochrome P450, family 3, subfamily A, polypeptide 4

Sinónimos:
CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1
Especie:
Human CYP3A4 (1576), Horse CYP3A4 (100294525), cow CYP3A4 (507988), dog CYP3A4 (479740), chicken CYP3A4 (416477)
ID UniProtKB:
P08684, P05184, Q16757, Q9UK50
ID del gen:
  • Human(1576) Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2011]
  • Horse(100294525) cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4
  • cow(507988) cytochrome P450, subfamily IIIA, polypeptide 4
  • dog(479740) cytochrome P450, family 3, subfamily A, polypeptide 4
  • chicken(416477) cytochrome P450, family 3, subfamily A, polypeptide 4

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Antibodies

Número de producto
Descripción
Reactividad de especies
Aplicación
ZRB3071
Anti-CYP3A4 Antibody, clone 2F2 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human
Aplicación
affinity binding assay
immunohistochemistry
western blot
AB1254
Anti-Cytochrome P450 Enzyme CYP3A4 Antibody, serum, Chemicon®,
Reactividad de especies
human, mammals, pig, rat
Aplicación
immunohistochemistry
western blot

Small Molecule - Inhibitor

Número de producto
Descripción
Especie
P49007
Piperine, ≥97%,
Especie
human
W290904
Piperine, ≥95%, FG,
Especie
human
I8898
Ivermectin, ,
Especie
mouse, human
E5389
Erythromycin, BioReagent, suitable for cell culture,
Especie
mouse, human
C6019
Clotrimazole, ,
Especie
mouse, human

Proteins

Número de producto
Descripción
Especie
MTOXCE3A4
CypExpress™ 3A4 Cytochrome P450 human, ,
Especie
human
H5042
Cytochrome P450 3A4 human, recombinant, expressed in E. coli,
Especie
human
C4982
Cytochrome P450 human, 3A4 isozyme microsomes, with P450 reductase and cytochrome b5, recombinant, expressed in baculovirus infected insect cells (BTI-TN-5B1-4),
Especie
human

esiRNA

Número de producto
Descripción
Especie
EHU148901
MISSION® esiRNA, targeting human CYP3A4,
Especie
human