E6376

红霉素

Name: 红霉素
Brand: SIAL

potency: ≥850 μg per mg

同義詞:

Erythromycin A

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經驗公式（希爾表示法）:

C₃₇H₆₇NO₁₃

CAS 編號:

114-07-8

分子量：:

733.93

UNSPSC Code:

51282304

NACRES:

NA.76

PubChem Substance ID:

24894626

EC Number:

204-040-1

Beilstein/REAXYS Number:

75279

MDL number:

MFCD00084654

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產品名稱

红霉素, potency: ≥850 μg per mg

InChI key

ULGZDMOVFRHVEP-RWJQBGPGSA-N

InChI

1S/C37H67NO13/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1

SMILES string

CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O

biological source

Streptomyces erythreus

form

powder

potency

≥850 μg per mg

color

white

solubility

ethanol: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

mode of action

protein synthesis | interferes

Quality Level

200

Gene Information

human ... ABCB1(5243), CYP3A4(1576), MLNR(2862)
mouse ... Abcb1a(18671), Abcb1b(18669)

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Show Differences

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本產品	E0774	PHR1039	BP781
Sigma-Aldrich E6376 红霉素	Sigma-Aldrich E0774 红霉素	Supelco PHR1039 红霉素	BP781 红霉素
mode of action protein synthesis \| interferes	mode of action protein synthesis \| interferes	mode of action -	mode of action -
antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria	antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria	antibiotic activity spectrum -	antibiotic activity spectrum -
Quality Level 200	Quality Level 200	Quality Level 300	Quality Level -
form powder	form solid	form -	form crystalline
biological source Streptomyces erythreus	biological source -	biological source -	biological source -
potency ≥850 μg per mg	potency -	potency -	potency -

Application

应用
红霉素是一种抗生素，是通过 红霉素链霉菌的某些菌株的生长而产生的。该产品主要由红霉素A和少量红霉素B和C组成，推荐浓度为100 mg/L. 50至200mg/L的浓度范围也被证明可有效控制细菌的生长。红霉素已被用作胃动素受体激动剂，以在体外阻断人气道中的呼吸糖结合物分泌， 并可用于质粒固化重组乳酸链球菌MG1363菌株的选择。

Biochem/physiol Actions

作用机制: 红霉素通过在转肽步骤中抑制延伸起作用，特别是通过结合细菌70S rRNA复合物的50S亚单位来抑制氨酰从A位点到P位点的易位。

抗菌谱：该产品可以抗革兰氏阴性和革兰氏阳性细菌。

Disclaimer

该产品在37℃下在溶液中可保持稳定3天。储备溶液应储存在2-8°C。

General description

化学结构：大环内酯

Preparation Note

该产品可以2mg/mL的浓度溶于水中，0.067％的水溶液的pH值为8.0-10.5。它也可以50mg/mL的浓度溶于乙醇中，获得澄清、无色至淡黄色的溶液。它易溶于醇、丙酮、氯仿、乙腈和乙酸乙酯中，但会与酸形成盐。所有溶液应保证避光。

存儲類別/等級

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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分析證明 (COA)

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Erythromycin for Gastric Emptying in Patients Undergoing General Anesthesia for Emergency Surgery: A Randomized Clinical Trial.

Christoph Czarnetzki et al.

JAMA surgery, 150(8), 730-737 (2015-06-18)

Patients undergoing emergency procedures under general anesthesia have impaired gastric emptying and are at high risk for aspiration of gastric contents. Erythromycin has strong gastric prokinetic properties. To evaluate the efficacy of erythromycin lactobionate in gastric emptying in patients undergoing

Design and synthesis of 2-arylbenzimidazoles and evaluation of their inhibitory effect against Chlamydia pneumoniae.

Leena Keurulainen et al.

Journal of medicinal chemistry, 53(21), 7664-7674 (2010-10-12)

Chlamydia pneumoniae is an intracellular bacterium that responds poorly to antibiotic treatment. Insufficient antibiotic usage leads to chronic infection, which is linked to disease processes of asthma, atherosclerosis, and Alzheimer's disease. The Chlamydia research lacks genetic tools exploited by other

Identification and characterization of the multidrug resistance gene cfr in a Panton-Valentine leukocidin-positive sequence type 8 methicillin-resistant Staphylococcus aureus IVa (USA300) isolate.

Anna C Shore et al.

Antimicrobial agents and chemotherapy, 54(12), 4978-4984 (2010-10-06)

The staphylococcal cfr gene mediates resistance to phenicols, lincosamides, oxazolidinones, pleuromutilins, and streptogramin A, a phenotype that has been termed PhLOPS(A). The cfr gene has mainly been associated with coagulase-negative staphylococcal isolates from animals, and only a few cfr-positive methicillin-resistant

Semimechanistic pharmacokinetic/pharmacodynamic model for assessment of activity of antibacterial agents from time-kill curve experiments.

Elisabet I Nielsen et al.

Antimicrobial agents and chemotherapy, 51(1), 128-136 (2006-10-25)

Dosing of antibacterial agents is generally based on point estimates of the effect, even though bacteria exposed to antibiotics show complex kinetic behaviors. The use of the whole time course of the observed effects would be more advantageous. The aim

Molecular architecture of Streptococcus pneumoniae TIGR4 pili.

Markus Hilleringmann et al.

The EMBO journal, 28(24), 3921-3930 (2009-11-28)

Although the pili of Gram-positive bacteria are putative virulence factors, little is known about their structure. Here we describe the molecular architecture of pilus-1 of Streptococcus pneumoniae, which is a major cause of morbidity and mortality worldwide. One major (RrgB)

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抗生素对蛋白质合成的抑制作用

蛋白质合成是一个复杂、多步骤过程，涉及到很多酶以及构象排列。但是，阻碍细菌蛋白质合成的大部分抗生素对该过程的干扰发生在70S细菌核糖体的30S亚基或50S亚基。

Inhibition of Protein Synthesis by Antibiotics

Antibiotics targeting bacterial ribosomes disrupt protein synthesis, a key process in bacterial growth inhibition.

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