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Merck

N0550000

新斯的明

European Pharmacopoeia (EP) Reference Standard

同義詞:

N,N,N-三甲基-2-[(二甲氨基)甲酰氧基]苯铵甲磺酸盐

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關於此項目

經驗公式（希爾表示法）:
C13H22N2O6S
CAS 編號:
51-60-5
分子量：:
334.39
NACRES:
NA.24
PubChem Substance ID:
329818445
UNSPSC Code:
41116107
MDL number:
MFCD00011796

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產品名稱

新斯的明, European Pharmacopoeia (EP) Reference Standard

InChI

1S/C12H19N2O2.CH4O4S/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5;1-5-6(2,3)4/h6-9H,1-5H3;1H3,(H,2,3,4)/q+1;/p-1

SMILES string

COS([O-])(=O)=O.CN(C)C(=O)Oc1cccc(c1)[N+](C)(C)C

InChI key

OSZNNLWOYWAHSS-UHFFFAOYSA-M

grade

pharmaceutical primary standard

API family

neostigmine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

Gene Information

human ... ACHE(43)

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1 of 4

本產品
1460000N2126N0500000
新斯的明 European Pharmacopoeia (EP) Reference Standard

N0550000

新斯的明

新斯的明 United States Pharmacopeia (USP) Reference Standard

USP

1460000

新斯的明

新斯的明

Sigma-Aldrich

N2126

新斯的明

新斯的明 European Pharmacopoeia (EP) Reference Standard

N0500000

新斯的明

manufacturer/tradename

EDQM

manufacturer/tradename

USP

manufacturer/tradename

-

manufacturer/tradename

EDQM

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

-

grade

pharmaceutical primary standard

format

neat

format

neat

format

-

format

neat

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

-

application(s)

pharmaceutical (small molecule)

API family

neostigmine

API family

neostigmine

API family

-

API family

neostigmine

Gene Information

human ... ACHE(43)

Gene Information

human ... ACHE(43)

Gene Information

human ... ACHE(43)

Gene Information

human ... ACHE(43)

Biochem/physiol Actions

乙酰胆碱酯酶的可逆抑制剂；不能穿过血脑屏障。
类似于毒扁豆碱的乙酰胆碱酯酶的可逆抑制剂，但是不能穿过血脑屏障。

Application

Neostigmine methyl sulfate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存儲類別/等級

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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分析證明 (COA)

Lot/Batch Number

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Michael Benatar et al.
The Cochrane database of systematic reviews, 12, CD005081-CD005081 (2012-12-14)
Approximately 50% of people with myasthenia gravis present with purely ocular symptoms, so called ocular myasthenia. Of these between 50% to 60% develop generalized disease, most within two years. Their management is controversial. This is an update of a review
Babar Kayani et al.
International journal of surgery (London, England), 10(9), 453-457 (2012-09-19)
A best evidence topic was written according to a structured protocol. In [patients with acute colonic pseudo-obstruction] is [neostigmine] superior to [conservative treatment] with respect to [duration of symptoms and complications]. In total 51 papers were found using the reported
Neostigmine reversal doesn't improve postoperative respiratory safety.
Matthew J Meyer et al.
BMJ (Clinical research ed.), 346, f1460-f1460 (2013-03-21)
Victor B Tsirline et al.
American journal of surgery, 204(6), 849-855 (2012-10-02)
Colonic pseudo-obstruction in critically ill patients may lead to devastating colonic perforation. Neostigmine is often the first-line intervention, because colonoscopy is more invasive and labor intensive. A retrospective 10-year review at a tertiary medical center identified 100 patients with Ogilvie's
Saraguaci Hernandez-Oliveira e Silva et al.
Muscle & nerve, 47(4), 591-593 (2013-03-06)
Crotamine is a basic, low-molecular-weight peptide that, at low concentrations, improves neurotransmission in isolated neuromuscular preparations by modulating sodium channels. In this study, we compared the effects of crotamine and neostigmine on neuromuscular transmission in myasthenic rats. We used a
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