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Merck

PHR1382

头孢曲松钠

Pharmaceutical Secondary Standard; Certified Reference Material

同義詞:

头孢曲松 二钠盐 半(七水合物)

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關於此項目

經驗公式(希爾表示法):
C18H16N8Na2O7S3 · 3.5H2O
CAS 編號:
分子量::
661.60
EC號碼:
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.24

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等級

certified reference material
pharmaceutical secondary standard

品質等級

agency

USP 1098184
traceable to Ph. Eur. C0691000

API 家族

ceftriaxone

CofA

current certificate can be downloaded

技術

HPLC: suitable
gas chromatography (GC): suitable

應用

pharmaceutical (small molecule)

形式

neat

儲存溫度

2-8°C

SMILES 字串

O.O.O.O.O.O.O.[Na+].[Na+].CO\N=C(/C(=O)N[C@H]1C2SCC(CSC3=NC(=O)C(=O)N([Na])N3C)=C(N2C1=O)C([O-])=O)c4csc(N)n4.CO\N=C(/C(=O)N[C@H]5C6SCC(CSC7=NC(=O)C(=O)N([Na])N7C)=C(N6C5=O)C([O-])=O)c8csc(N)n8

InChI

1S/2C18H18N8O7S3.4Na.7H2O/c2*1-25-18(22-12(28)13(29)23-25)36-4-6-3-34-15-9(14(30)26(15)10(6)16(31)32)21-11(27)8(24-33-2)7-5-35-17(19)20-7;;;;;;;;;;;/h2*5,9,15H,3-4H2,1-2H3,(H5,19,20,21,23,27,29,31,32);;;;;7*1H2/q;;4*+1;;;;;;;/p-4/b2*24-8-;;;;;;;;;;;/t2*9-,15-;;;;;;;;;;;/m11.........../s1

InChI 密鑰

PMRZKYOXTPBIQF-MAODNAKNSA-J

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本產品
PHR1847PHR2099PHR1605
application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical small molecule

application(s)

pharmaceutical (small molecule)

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

format

neat

format

-

format

-

format

neat

Quality Level

300

Quality Level

300

Quality Level

300

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

grade

certified reference material, pharmaceutical secondary standard

grade

certified reference material, pharmaceutical secondary standard

grade

certified reference material, pharmaceutical secondary standard

storage temp.

2-8°C

storage temp.

-10 to -25°C

storage temp.

2-8°C

storage temp.

-10 to -25°C

一般說明

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

應用

Ceftriaxone Sodium may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations[1][2][3] and serum samples[2][3] by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

其他說明

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
To see an example of a Certificate of Analysis for this material enter LRAC3447 in the slot below. This is an example certificate only and may not be the lot that you receive.

象形圖

Health hazardExclamation mark

訊號詞

Danger

危險分類

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號,寫有 ‘Lot’或‘Batch’.。

已經擁有該產品?

您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

Validation of an HPLC-UV method for the determination of ceftriaxone sodium residues on stainless steel surface of pharmaceutical manufacturing equipments
Akl MA, et al.
Journal of Pharmaceutical and Biomedical Analysis, 55(2), 247-252 (2011)
Simultaneous Determination of Ceftriaxone Sodium and Non Steroidal Anti?Inflammatory Drugs in Pharmaceutical Formulations and Human Serum by RP?HPLC.
Sultana N, et al.
J. Chin. Chem. Soc., 57(6), 1278-1285 (2010)
Simultaneous determination of ceftriaxone sodium and statin drugs in pharmaceutical formulations and human serum by RP-HPLC.
Sultana N, et al.
Journal of the Chilean Chemical Society, 55(2), 193-198 (2010)
Scott V Monte et al.
Expert opinion on drug safety, 7(5), 515-523 (2008-09-02)
Isolated reports of neonatal and infant deaths associated with ceftriaxone-calcium precipitation in the lungs and kidneys have prompted a recommendation from the US FDA in June 2007 advising that in patients of all ages, calcium-containing solutions should not be administered
Tatiana Barichello et al.
Journal of neuroimmunology, 272(1-2), 35-41 (2014-05-27)
Neonatal Escherichia coli meningitis continues to be an important cause of mortality and morbidity in newborns worldwide. The aim of this study was to investigate the cytokines/chemokines, brain-derived neurotrophic factor (BDNF) levels, blood-brain barrier integrity in neonatal rats following E.

Questions

1–3 of 3 Questions  
  1. What is the active fraction of Ceftriaxone in Cftriaxone sodium(PHR1382-1G)?

    1 answer
    1. The active fraction is not reported for this secondary standard. However, this material contains 3.5 parts water and 2 parts sodium. The percentage of the active pharmaceutical ingredient (Ceftriaxone) is approximately 83.5%. Please see the link to access a sample or lot specific Certificate of Analysis:
      https://www.sigmaaldrich.com/product/sial/phr1382#product-documentation

      Helpful?

  2. Guten Tag, wo finde ich die Potenz des Antibiotikums? Und wie viele Gram m ist in einer Packung/Flasche?

    1 answer
    1. Unfortunately, the potency is not determined for this product. The active fraction is approximately 83.5%.

      Helpful?

  3. PHR1382 Supelco Ceftriaxone Sodium Please provide the assay purity by HPLC, measured water content and active fraction of the product

    1 answer
    1. The information requested is lot specific and reported in the Certificate of Analysis. Please see the link below to access the lot of interest:
      https://www.sigmaaldrich.com/search

      Helpful?

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