MilliporeSigma

GABRA1

gamma-aminobutyric acid (GABA) A receptor, alpha 1

Synonyms:
ECA4, EJM, EJM5
Species:
UniProtKB ID:
Gene ID:
  • Human(2554) Summary: This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(14394) gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1
  • Rat(29705) gamma-aminobutyric acid (GABA) A receptor, alpha 1
  • domestic guinea pig(100721626) gamma-aminobutyric acid (GABA) A receptor, alpha 1
  • cow(780973) gamma-aminobutyric acid (GABA) A receptor, alpha 1
  • dog(489143) gamma-aminobutyric acid (GABA) A receptor, alpha 1
  • naked mole-rat(101719179) gamma-aminobutyric acid (GABA) A receptor, alpha 1
  • Zebrafish(768183) gamma-aminobutyric acid (GABA) A receptor, alpha 1
  • sheep(101117759) gamma-aminobutyric acid (GABA) A receptor, alpha 1
  • chicken(374214) gamma-aminobutyric acid (GABA) A receptor, alpha 1
  • domestic cat(100286792) gamma-aminobutyric acid (GABA) A receptor, alpha 1

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Small Molecule - Agonist

Product Number
Description
Species
Gaboxadol hydrochloride, solid, ≥98% (HPLC),
Species
human
Piperidine-4-sulfonic acid, ,
Species
human
Isoguvacine hydrochloride, solid,
Species
human
Muscimol hydrobromide, ≥98% (HPLC), solid,
Species
human
Oxazepam, ,
Species
human

Small Molecule - Allosteric Modulator

Product Number
Description
Species
Zaleplon, United States Pharmacopeia (USP) Reference Standard,
Species
human
Zolpidem solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Species
human
Zaleplon solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Species
human
Zolpidem for system suitability, CRS, European Pharmacopoeia (EP) Reference Standard,
Species
human
Dehydroisoandrosterone 3-sulfate sodium salt dihydrate, ≥93% (TLC), powder,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
Norfloxacin, analytical standard, ≥98% (TLC),
Species
rat, human
Ciprofloxacin, ≥98% (HPLC),
Species
rat, human
Ofloxacin, fluoroquinolone antibiotic,
Species
rat, human
Etiocholan-3α-ol-17-one, ,
Species
human, rat
Ro 15-4513, solid,
Species
rat, human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-GABRA1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
western blot
Anti-GABA A Receptor β2/3 Antibody, clone 62-3G1, Upstate®, from mouse,
Species Reactivity
bovine, human, rat
Application
immunohistochemistry
immunoprecipitation (IP)

western blot
Anti-GABA A Receptor α1 chain Antibody, NT, clone BD24, clone BD24, Chemicon®, from mouse,
Species Reactivity
avian, bovine, human, pig
Application
immunohistochemistry
immunoprecipitation (IP)

western blot
Anti-GABRA1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, human, rabbit
Application
western blot
Anti-GABA antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
drosophila, rat, wide range
Application
dot blot
immunohistochemistry

Small Molecule - Inhibitor

Product Number
Description
Species
2,6-Xylenol, ≥99%, FG,
Species
human
2-Isopropylphenol, 98%,
Species
human
1,3-Diisopropylbenzene, 96%,
Species
human
2-Isopropylphenol, ≥98%, FG,
Species
human
2,6-Dimethylphenol, 99%,
Species
human

Small Molecule - Ligand

Product Number
Description
Species
Ethyl alcohol, Pure, 200 proof, for molecular biology,
Species
human
Etomidate, >98% (HPLC), powder,
Species
human
Flumazenil, >99% (HPLC), solid,
Species
rat, human
Carbamazepine, powder,
Species
rat, human
2-Bromo-2-chloro-1,1,1-trifluoroethane, ≥99%,
Species
human

Small Molecule - Mixed Agonist/Antagonist

Product Number
Description
Species
2-Hydroxy-3-isopropylbenzoic acid, 98%,
Species
human
2,6-Dimethoxyphenol, 99%,
Species
human
2,6-Dimethoxyphenol, natural, ≥96%,
Species
human
Phenol, ≥99%,
Species
human
Phenol, contains hypophosphorous as stabilizer, loose crystals, ACS reagent, ≥99.0%,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human GABRA1,
Species
human
MISSION® esiRNA, targeting mouse Gabra1,
Species
mouse