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This product may be dissolved in water at 20 mg/ml and ethanol at 10 mg/ml. The solubility directly into PBS has not been evaluated.
A6402
[Asn1, Val5]-Angiotensin II
≥97% (HPLC), angiotensin agonist, powder
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$40.97
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$175.00
About This Item
Empirical Formula (Hill Notation):
C49H70N14O11
CAS Number:
Molecular Weight:
1031.17
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.32
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Product Name
[Asn1, Val5]-Angiotensin II, ≥97% (HPLC)
Quality Level
assay
≥97% (HPLC)
form
powder
storage temp.
−20°C
SMILES string
CC(C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(O)=O
InChI
1S/C49H70N14O11/c1-26(2)39(61-42(67)33(12-8-18-55-49(52)53)57-41(66)32(50)23-38(51)65)45(70)58-34(20-29-14-16-31(64)17-15-29)43(68)62-40(27(3)4)46(71)59-35(22-30-24-54-25-56-30)47(72)63-19-9-13-37(63)44(69)60-36(48(73)74)21-28-10-6-5-7-11-28/h5-7,10-11,14-17,24-27,32-37,39-40,64H,8-9,12-13,18-23,50H2,1-4H3,(H2,51,65)(H,54,56)(H,57,66)(H,58,70)(H,59,71)(H,60,69)(H,61,67)(H,62,68)(H,73,74)(H4,52,53,55)/t32-,33-,34-,35-,36-,37-,39-,40-/m0/s1
InChI key
JYPVVOOBQVVUQV-CGHBYZBKSA-N
Gene Information
human ... AGTR1(185)
mouse ... AGTR1(11607)
rat ... AGTR1(24180)
Related Categories
1 of 4
This Item | A2900 | A9525 | A8846 |
|---|---|---|---|
| form powder | form powder | form powder | form - |
| assay ≥97% (HPLC) | assay ≥95% (HPLC) | assay ≥93% (HPLC) | assay - |
| Quality Level 200 | Quality Level 200 | Quality Level 300 | Quality Level 100 |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. - |
| Gene Information human ... AGTR1(185) | Gene Information human ... AGTR1(185) | Gene Information human ... AGT(183) | Gene Information human ... AGTR1(185) |
Amino Acid Sequence
Asn-Arg-Val-Tyr-Val-His-Pro-Phe
General description
Application
[Asn1, Val5]-Angiotensin II has been used:
- to study the effects of ACTH, serotonin, Ang II, carbachol and elevated [K+] on catecholamine and serotonin release[4]
- to induce cyclophilin D (CypD)–dependent mitochondrial vascular superoxide (O2. - ) production in hypertension[5]
- to increase the homocysteine-induced ER stress-inducible, ubiquitin-like domain member 1 (HERPUD1) protein level in HeLa cells[6]
Biochem/physiol Actions
Angiotensin II functions as a vasoconstrictor and controls cardiovascular function.[7] It maintains water-sodium homeostasis, modulates cellular proliferation and vascular remodelling of renin-angiotensin system.[8] Angiotensin II has inflammatory effects.[1]
Synthetic angiotensin agonist that is involved in the regulation of blood pressure, water consumption, and hydromineral balance in fish.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Angiotensin II type I receptor (AT1R) is an independent prognosticator of esophageal squamous cell carcinoma and promotes cells proliferation via mTOR activation
Li SH, et al.
Oncotarget, 7(41), 67150-67150 (2016)
HERPUD1 protects against oxidative stress-induced apoptosis through downregulation of the inositol 1, 4, 5-trisphosphate receptor
Paredes F, et al.
Free Radical Biology & Medicine, 90, 206-218 (2016)
J Fuentes et al.
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 167(6), 438-443 (1997-08-01)
Drinking in Atlantic salmon (Salmo salar) juveniles was investigated in fresh water and following transfer to sea water. There was a significant effect of fish size on drinking, and smolts (20-30 g) imbibed about ten times less water than alevins
Effect of Angiotensin II Receptor Type 1 Antibodies on Kidney Allograft Function
Savaj S, et al.
Iranian Journal of Kidney Diseases, 12(2), 120-120 (2018)
Mitochondrial Cyclophilin D in Vascular Oxidative Stress and HypertensionNovelty and Significance
Itani HA, et al.
Hypertension, 67(6), 1218-1227 (2016)
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水やPBSには溶けますでしょうか。また溶解度はいかがでしょうか。
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