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Cycloaromatization approach to polysubstituted indolizines from 2-acetylpyrroles: decoration of the pyridine unit.

The Journal of organic chemistry (2013-01-08)
Jin Ho Lee, Ikyon Kim
ABSTRACT

A new synthetic route to indolizines with various substituents on the pyridine moiety was developed by utilizing a facile cycloaromatization of 2-acetylpyrrole derivatives. Without isolation, the resulting intermediates were allowed to react with various electrophiles to afford a range of indolizines. In particular, Suzuki-Miyaura cross-coupling of O-triflates with (hetero)arylboronic acids permitted introduction of diverse substituents at the C8 position of an indolizine skeleton.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Methyl 2-pyrrolyl ketone, ≥98%, FG
Sigma-Aldrich
2-Acetylpyrrole, ReagentPlus®, 99%

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