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GABA suppresses neurogenesis in the adult hippocampus through GABAB receptors.

Development (Cambridge, England) (2013-11-29)
Claudio Giachino, Michael Barz, Jan S Tchorz, Mercedes Tome, Martin Gassmann, Josef Bischofberger, Bernhard Bettler, Verdon Taylor
ABSTRACT

Adult neurogenesis is tightly regulated through the interaction of neural stem/progenitor cells (NSCs) with their niche. Neurotransmitters, including GABA activation of GABAA receptor ion channels, are important niche signals. We show that adult mouse hippocampal NSCs and their progeny express metabotropic GABAB receptors. Pharmacological inhibition of GABAB receptors stimulated NSC proliferation and genetic deletion of GABAB1 receptor subunits increased NSC proliferation and differentiation of neuroblasts in vivo. Cell-specific conditional deletion of GABAB receptors supports a cell-autonomous role in newly generated cells. Our data indicate that signaling through GABAB receptors is an inhibitor of adult neurogenesis.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
γ-Aminobutyric acid, ≥99%
Sigma-Aldrich
γ-Aminobutyric acid, BioXtra, ≥99%