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Study of the persistence of the anti-inflammatory effect observed after application of preparations containing organic ultraviolet filters.

International journal of pharmaceutics (2014-10-01)
C Couteau, C Chauvet, E Paparis, L J M Coiffard
ABSTRACT

Given that previous studies have highlighted the anti-inflammatory nature, which is influenced by UV radiation, of a certain number of ultraviolet filters currently used in Europe, it seemed interesting to evaluate the persistence of this type of effect. The persistence of the anti-inflammatory effect of fourteen preparations, each containing one of the ultraviolet filters authorized by Regulation (CE) No. 1223/2009, and of 10 commercially-available sun products was studied using the phorbol-myristate-acetate test on mice, up to 6 and a half hours after application. We can observe that a benzophenone, oxybenzone, a PABA derivative, octyldimethylPABA and a derivative of cinnamic acid, OMC as well as 3 commercially-available products, display a very marked anti-inflammatory effect at the end of our experimentation phase. The type of effect observed could encourage users to prolong the time that they are exposed to the sun, due to there being no warning signs, namely sunburn.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Glycerol, for molecular biology, ≥99.0%
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Triethylamine, ≥99.5%
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Phorbol 12-myristate 13-acetate, ≥99% (TLC), film or powder
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Glycerol, ≥99.5%
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Triethylamine, ≥99%
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Glycerol, ACS reagent, ≥99.5%
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Triethanolamine, ≥99.0% (GC)
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Glycerol, ReagentPlus®, ≥99.0% (GC)
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Triethylamine, puriss. p.a., ≥99.5% (GC)
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Glycerol, BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for electrophoresis, ≥99% (GC)
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Titanium(IV) oxide, nanopowder, 21 nm primary particle size (TEM), ≥99.5% trace metals basis
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Stearic acid, Grade I, ≥98.5% (capillary GC)
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Triethylamine, BioUltra, ≥99.5% (GC)
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Titanium(IV) oxide, anatase, nanopowder, <25 nm particle size, 99.7% trace metals basis
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Triethanolamine, reagent grade, 98%
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Stearic acid, reagent grade, 95%
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Glycerin, Pharmaceutical Secondary Standard; Certified Reference Material
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Glycerol solution, 83.5-89.5% (T)
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Stearic acid, ≥95%, FCC, FG
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Titanium(IV) oxide, anatase, powder, 99.8% trace metals basis
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Titanium(IV) oxide, ReagentPlus®, ≥99%
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Glycerol, BioUltra, for molecular biology, anhydrous, ≥99.5% (GC)
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