Saturated N-heterocyclic building blocks are of growing importance but their installation has been challenging due to poor commercial availability and the often long, laborious synthetic routes needed to form these ring systems.
SnAP Reagents are an ever-expanding class of reagents, which are now available for the convenient synthesis of medium-ring (6-9 membered) saturated N-heterocycles, including bicyclic and spirocyclic structures. In collaboration with the Bode research group, many of the SnAP Reagents are now commercially available, and custom-made reagents for specific applications or targets can also be prepared from simple starting materials.
SnAP reagents are stable and readily available and can be coupled with widely available aromatic, heteroaromatic, aliphatic, and glyoxylic aldehydes using versatile and predictable methodology, developed within the Bode group, for the synthesis of saturated N-heterocycles. A general procedure from the review is shown below.