Verkade's bases, football-shaped proazaphosphatrane molecules of type 1, are very strong bases due to the extraordinary stability of 2 when 1 reacts with a proton.
Due to the stability of the protonated form 2, Verkade's bases are about eight orders of magnitude stronger as a Lewis base than any amine known, including the prominently used DBU, DBN and Proton Sponge. (14795).
Applications: Verkade's bases have been successfully applied in a variety of organic reactions, such as alkylations, dehydrohalogenations, acylations, a variety of condensation and organometallic reactions for carbon-carbon bond formation. A second characteristic of the novel cage molecules of type 1 is their ability to act as a superior catalyst for a continuously widening range of reactions[3-6] such as protecting alcohol groups with various silyl groups during multistep syntheses, trimerizing isocyanates to isocyanurates and the synthesis of alpha, beta-unsaturated nitriles..
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