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Phleomycin

Name: Phleomycin
Brand: SIGMA
Price: 126 USD

from Streptomyces verticillus, powder, DNA replication inhibitor

Synonym(s):

FT-0697305

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Size/SKU	Availability	Price
5 mg	Check Cart for Availability	$126.00
25 mg	Check Cart for Availability	$420.00
100 mg	Check Cart for Availability	$1,400.00

About This Item

CAS Number:

11006-33-0

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00131846

Form:

powder

$126.00

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Properties

Product Name

Phleomycin from Streptomyces verticillus, powder

form

powder

Quality Segment

200

shelf life

2 yr

color

blue

antibiotic activity spectrum

fungi

mode of action

DNA synthesis | interferes

storage temp.

2-8°C

InChI

1S/C51H75N17O21S2/c1-16-29(65-41(68-38(16)54)21(8-27(53)72)60-9-20(52)39(55)78)44(82)67-31(34(22-10-58-15-61-22)88-49-50(5,36(76)33(74)25(11-69)87-49)89-47-37(77)51(85,48(57)84)35(75)26(12-70)86-47)45(83)62-18(3)32(73)17(2)42(80)66-30(19(4)71)43(81)59-7-6-28-63-24(14-90-28)46-64-23(13-91-46)40(56)79/h10,13,15,17-18,20-21,24-26,30-37,47,49,60,69-70,73-77,85H,6-9,11-12,14,52H2,1-5H3,(H2,53,72)(H2,55,78)(H2,56,79)(H2,57,84)(H,58,61)(H,59,81)(H,62,83)(H,66,80)(H,67,82)(H2,54,65,68)/t17?,18?,20?,21?,24?,25-,26?,30?,31?,32?,33+,34?,35-,36-,37-,47-,49-,50-,51+/m0/s1

InChI key

QRBLKGHRWFGINE-UGWAGOLRSA-N

Description

General description

Phleomycin is a glycopeptide antibiotic and is a member of the bleomycin family.

Application

Phleomycin from Streptomyces verticillus has been used as an antibiotic in the screening of transformants of Trypanosoma brucei. It has also been used as an antibiotic in the maintenance of Escherichia coli.

Biochem/physiol Actions

Phleomycin can bind and intercalate with the DNA that leads to DNA strand breaks. It acts as an inhibitor of DNA replication.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

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Show Differences

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This Item	15361	B2434	B5507
Sigma-Aldrich P9564 Phleomycin from Streptomyces verticillus	Sigma-Aldrich 15361 Bleomycin sulfate from Streptomyces verticillus	Sigma-Aldrich B2434 Bleomycin sulfate from Streptomyces verticillus	Sigma-Aldrich B5507 Bleomycin sulfate from Streptomyces verticillus
description powder	description suitable for fluorescence, mixture of bleomycin sulfate salts, lyophilized, powder or crystals, white to off-white	description BioXtra, crystalline	description crystalline, 1.5-2.0 U/mg
form powder	form powder or crystals	form crystalline	form crystalline
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
color blue	color white to off-white	color -	color white to off-white
antibiotic activity spectrum fungi	antibiotic activity spectrum Gram-positive bacteria, neoplastics, Gram-negative bacteria	antibiotic activity spectrum Gram-negative bacteria, neoplastics, Gram-positive bacteria	antibiotic activity spectrum fungi
shelf life 2 yr	shelf life -	shelf life -	shelf life -

Pictograms

GHS07

Signal Word

Warning

Hazard Codes

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

dust mask type N95 (US), Eyeshields, Gloves

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