8.52005

Fmoc-Asp(OtBu)-OH

Novabiochem^®

• Synonym(s): Fmoc-Asp(OtBu)-OH, N-α-Fmoc-L-aspartic acid β-t.-butyl ester
• Empirical Formula (Hill Notation): C₂₃H₂₅NO₆
• CAS Number: 71989-14-5
• Molecular Weight: 411.45
• MDL number: MFCD00037131
• UNSPSC Code: 12352209
• EC Index Number: 276-251-7
• NACRES: NA.22

Properties

• Quality Level: 400
• product line: Novabiochem^®
• assay: ≥98% (TLC); ≥98.0% (acidimetric); ≥99.0% (HPLC)
• form: powder
• reaction suitability: reaction type: Fmoc solid-phase peptide synthesis
• manufacturer/tradename: Novabiochem^®
• mp: 143-150 °C
• application(s): peptide synthesis
• functional group: carboxylic acid
• storage temp.: 2-30°C
• SMILES string: N([C@@H](CC(=O)OC(C)(C)C)C(=O)[O-])C(=O)OCC1c2c(cccc2)c3c1cccc3
• InChI: 1S/C23H25NO6/c1-23(2,3)30-20(25)12-19(21(26)27)24-22(28)29-13-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,12-13H2,1-3H3,(H,24,28)(H,26,27)/p-1/t19-/m0/s1
• InChI key: FODJWPHPWBKDON-IBGZPJMESA-M

Description

General description

High purity Fmoc-protected amino acid for research and process production of peptides, with very low levels of dipeptide, free-amino acids and acetic acid impurities.
Standard building block for introduction of aspartic acid amino-acid residues by Fmoc SPPS

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Application

• Silybin liver research: Silybin A and B, as part of the silymarin complex, are extensively studied for their hepatoprotective properties. They play a crucial role in liver health by mitigating oxidative stress and enhancing regenerative processes in hepatic tissue (Cai et al., 2024).


• Silybin pharmacological research: The pharmacological effects of silybin, particularly its roles in inhibiting inflammation and modulating drug metabolizing enzymes, make it a valuable compound in therapeutic research, particularly for its benefits in hepatology and oncology (Hammad et al., 2024).

Analysis Note

Colour (visual): white to off white
Appearance of substance (visual): powder
Colour index (0,5 M in DMF): ≤ 150 Hazen
Identity (IR): passes test
Enantiomeric purity: ≥ 99.8 % (a/a)
Purity (HPLC): ≥ 99.0 % (a/a)
Fmoc-ß-Ala-OH (HPLC): ≤ 0.1 % (a/a)
Fmoc-ß-Ala-Asp (OtBu)-OH (HPLC): ≤ 0.1 % (a/a)
Fmoc-Asp(OtBu)-Asp(OtBu)-OH (HPLC): ≤ 0.1 % (a/a)
Fmoc-Asp-OH (HPLC): ≤ 0.1 % (a/a)
Assay free amino acid (GC): ≤ 0.2 %
Purity (TLC(011A)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Solubility (25 mmole in 50 ml DMF): clearly soluble
Assay (acidimetric): ≥ 98.0 %
Water (K. F.): ≤ 2.0 %
Ethyl acetate (HS-GC): ≤ 0.5 %
Acetate (IC): ≤ 0.02 %

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Other Notes

Replaces: 04-12-1013

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable