[Skip to Content](https://www.sigmaaldrich.com#main-content) [![MilliporeSigma](https://www.sigmaaldrich.com/static/logos/purple/millipore_sigma.svg)](https://www.sigmaaldrich.com/US/en) Products Cart0 USEN Products ProductsApplicationsServicesResourcesSupport [Analytical Chemistry](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry)[Cell Culture & Analysis](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis)[Chemistry & Biochemicals](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals)[Clinical & Diagnostics](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics)[Filtration](https://www.sigmaaldrich.com/US/en/products/filtration) [Greener Alternative Products](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/greener-alternative-products) [Industrial Microbiology](https://www.sigmaaldrich.com/US/en/products/industrial-microbiology)[Lab Automation](https://www.sigmaaldrich.com/US/en/products/lab-automation)[Labware](https://www.sigmaaldrich.com/US/en/products/labware)[Materials Science](https://www.sigmaaldrich.com/US/en/products/materials-science)[Molecular Biology & Functional Genomics](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics)[mAbs Development & Manufacturing](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies)[mRNA Development & Manufacturing](https://www.sigmaaldrich.com/US/en/integrated-offerings/mrna-development-manufacturing)[Pharma & Biopharma Manufacturing](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing)[Protein Biology](https://www.sigmaaldrich.com/US/en/products/protein-biology)[Water Purification](https://www.sigmaaldrich.com/US/en/products/water-purification) [Analytical Chemistry](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry)[Cell Culture & Analysis](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis)[Chemistry & Synthesis](https://www.sigmaaldrich.com/US/en/applications/chemistry-and-synthesis) [Clinical & Diagnostics](https://www.sigmaaldrich.com/US/en/applications/clinical-testing-and-diagnostics-manufacturing)[Environmental & Cannabis Testing](https://www.sigmaaldrich.com/US/en/applications/environmental-testing-and-industrial-hygiene)[Food & Beverage Testing & Manufacturing](https://www.sigmaaldrich.com/US/en/applications/food-and-beverage-testing-and-manufacturing)[Genomics](https://www.sigmaaldrich.com/US/en/applications/genomics)[Materials Science & Engineering](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering)[Microbiological Testing](https://www.sigmaaldrich.com/US/en/applications/microbiological-testing)[mAbs Development & Manufacturing](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies)[mRNA Development & Manufacturing](https://www.sigmaaldrich.com/US/en/integrated-offerings/mrna-development-manufacturing)[Pharma & Biopharma Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing)[Protein Biology](https://www.sigmaaldrich.com/US/en/applications/protein-biology)[Research & Disease Areas](https://www.sigmaaldrich.com/US/en/applications/research-disease-areas)[Water Purification](https://www.sigmaaldrich.com/US/en/applications/water-purification) [Contract Manufacturing](https://www.sigmaaldrich.com/US/en/services/contract-manufacturing)[Contract Testing](https://www.sigmaaldrich.com/US/en/services/contract-testing)[Custom Products](https://www.sigmaaldrich.com/US/en/services/custom-products)[Digital Solutions for Life Science](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms)[IVD Development & Manufacturing](https://www.sigmaaldrich.com/US/en/services/ivd-development-manufacturing)[Product Services](https://www.sigmaaldrich.com/US/en/services/product-services)[Support](https://www.sigmaaldrich.com/US/en/services/support) [Documents](https://www.sigmaaldrich.com/US/en/documents-search?tab=coa) [Learning CenterNew](https://www.sigmaaldrich.com/US/en/life-science/learning-center) [Customer Support](https://www.sigmaaldrich.com/US/en/support/customer-support) [Contact Us](https://www.sigmaaldrich.com/US/en/collections/offices) [Get Site Smart](https://www.sigmaaldrich.com/US/en/life-science/ecommerce/website-update-info) [FAQ](https://maestro.my.site.com/knowledgeportal/s/) [Quality & Regulatory](https://www.sigmaaldrich.com/US/en/life-science/quality-and-regulatory-management) [Calculators & Apps](https://www.sigmaaldrich.com/US/en/support/calculators-and-apps) [Webinars](https://www.sigmaaldrich.com/US/en/collections/webinars) [Login / Register](https://www.sigmaaldrich.com/oidc-sign-in) [Order Lookup](https://www.sigmaaldrich.com/US/en/order-lookup) [Quick Order](https://www.sigmaaldrich.com/US/en/quick-order) Cart0 [Home](https://www.sigmaaldrich.com/US/en)[Polymer Synthesis](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/polymer-synthesis)Functional Biomaterials Synthesized by Double-Head Polymerization Agents # Functional Biomaterials Synthesized by Double-Head Polymerization Agents __Hua Wei1, Suzie H. Pun2__ 1Lanzhou University, Lanzhou China, 2University of Washington [[email protected]](mailto:[email protected]) ## Introduction Over the past two decades, the rapid advance of controlled living polymerization (CLP) techniques, such as ring-opening polymerization (ROP),1 nitroxide-mediated polymerization (NMP),2 atom transfer free radical polymerization (ATRP),3 and reversible addition-fragmentation chain transfer (RAFT) polymerization,4 has enabled synthesis of welldefined polymers with controlled molecular weight and narrow molecular weight distribution (MWD) that are tailor-made for biomedical applications. There is an increasing demand for multifunctional synthetic polymers capable of interacting with, mimicking, or replacing natural materials for use in applications such as drug delivery, molecular imaging, cell therapy, and tissue engineering. One common strategy for the synthesis of multifunctional materials is to combine different synthetic techniques that involve complicated and multistep preparation and purification.5 The result, however, is often low reaction yield, batch-tobatch variation, and difficulties in scale-up. Thus, there is considerable need for simplified approaches to synthesis of polymers with advanced architectures and/or bioactive properties. This is particularly important for biomedical applications where simplified synthetic methods are advantageous for scale-up, manufacturing, and FDA approval. Doublehead polymerization agents have been developed to meet this demand and provide an elegant and robust approach to achieve this aim. These agents provide a nucleus that integrates different synthetic methods: e.g., CLP,1-4 click chemistry,6 and thiol chemistry.7 Double-head agents, (also called dual, bifunctional, or heterofunctional initiators) contain two functional sites capable of initiating concurrent polymerization independently and selectively. The use of double-head agents offers three advantages over conventional methods for polymer synthesis. The double-head agent: 1) provides an opportunity to prepare block copolymers in a concurrent, one-step manner without the need for intermediate transformation and protection steps, which is especially useful for the synthesis of block copolymers based on mechanistically incompatible monomers; 2) offers flexibility to the central bridge (block junction) connecting both functional ends that can be customized to meet the requirements for specific applications; and 3) affords two functional termini for the resulting block copolymer. This review highlights recent progress in this field, with an emphasis on two types of double-head agents with symmetric and asymmetric structures, respectively (__Table 1__ on the following page). The preparation of polymers using these double-head agents and their biomedical applications are summarized in __Figure 1__. Finally, a perspective on the future direction of this rapidly developing research field is presented. ![biomaterials synthesized](https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/images/technical-documents/articles/materials-science-and-engineering/polymer-synthesis/biomaterials-synthesized/biomaterials-synthesized.jpg "biomaterials-synthesized") __Figure 1.__ Examples of biomaterials synthesized using double-head agents covered in this review. Adapted with permission from the references as follows: Copyright (2013, 2011, 2008) American Chemical Society.20,22,29 Copyright (2006) John Wiley and Sons.9 Copyright (2010) Royal Society of Chemistry.25 Copyright (2013) Nature Publishing Group. ![double head agents](https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/images/technical-documents/articles/materials-science-and-engineering/polymer-synthesis/double-head-agents/double-head-agents.jpg "double-head-agents") __Table 1.__Summary of double-head agents with various structures. ## Symmetrical Double-head Agents Symmetrical double-head agents contain the same functional group at each end and are used to initiate simultaneous polymerization from both sides of the agent. These agents have been used to synthesize polymers with internal degradable bridges and also to incorporate functional termini in the cleaved polymer. Tsarevsky and Matyjaszewski first reported the design of a degradable disulfide-bridged bifunctional ATRP initiator, bis\[2-(2-bromopropionyloxy) ethyl] disulfide (BBPrEDS) (Prod. No. [723169](https://www.sigmaaldrich.com/US/en/product/aldrich/723169)) for the synthesis of degradable linear polystyrene (PS).8 Dithiothreitol (DTT) was used as a reducing agent to break the disulfide bridge and to obtain free thiolterminated PS with half the molecular weight of the parent polymer. The BBPrEDS bifunctional initiator was used by Armes and co-workers to synthesize an ABA triblock copolymer by polymerizing first 2-(methacryloyloxy)ethyl phosphorylcholine (MPC) followed by N-isopropylacrylamide (NIPAAm), resulting in the PNIPAM80–PMPC125-SS-PMPC125–PNIPAM80 ABA triblock copolymer.9 This triblock copolymer formed a free-standing gel under physiologically relevant conditions at 37 °C and a copolymer concentration above approximately 8% (w/v). Cleavage of the central disulfide bond by biomolecules such as glutathione caused irreversible dissolution of the micellar gel. These copolymers constitute a new class of injectable gelators that are both biochemically responsive and thermo-responsive and could be useful as depots for localized drug or cell delivery. Haddleton et al. reported the synthesis of two bifunctional ATRP initiators bearing Diels–Alder adducts—one based on a furan–maleimide adduct and the other based on an anthracene–maleimide adduct—which were used for the synthesis of linear poly(methyl methacrylate) (PMMA).10 The presence of the Diels–Alder adduct in the middle of the polymer chains allowed for their temperature-modulated reversible cleavage. These “selfhealing polymers” can be degraded by heating at high temperature and reformed by heating at lower temperature. In another example, Zhao’s group developed a degradable disulfidebridged bifunctional RAFT chain transfer agent (CTA), S-cyanopentanoic acid dithiobenzoate (S-CPDB).11 In their study, RAFT and ROP were used with S-CPDB to prepare symmetric reduction-responsive amphiphilic star-like terpolymers. Upon redox stimuli and end-group modification, the resulting starlike terpolymers were efficiently converted into thiolfunctionalized telechelic stars, degraded miktoarm stars, and comb-like linear multiblock copolymers *__via__* various thiol modification reactions. Bis(2-hydroxyethyl)disulfide (HES) (Prod. No. [380474](https://www.sigmaaldrich.com/US/en/product/aldrich/380474)) is a degradable disulfide-bridged bifunctional initiator that has been widely used to generate aliphatic polycarbonates by ROP of cyclic carbonates. Zhong et al. prepared poly(ethylene glycol)-b-PCL (PEG-SS-PCL) diblock copolymers by first synthesizing biodegradable poly(ε-caprolactone) disulfides, PCL-SS-PCL, through ROP of ε-caprolactone using HES initiator, reducing the polymers and reacting via disulfide exchange with PEG orthopyridyl disulfide.12 The reducible PEG-SS-PCL diblock copolymers were used for micellar delivery of the anticancer drug doxorubicin (Dox). Compared to a reduction-insensitive control material, the shell-sheddable micelles released Dox faster in the intracellular environment, resulting in higher anticancer efficacy. ## Asymmetrical Double-head Agents The synthesis of block copolymers based on mechanistically incompatible monomers using asymmetrical double-head agents has attracted considerable attention due to the simplified synthesis and the possibility of a concurrent, one-step process. The hetero double-head agent has two different functional groups that can perform two mechanistically different reactions/polymerizations without intermediate transformation steps. To obtain well-defined block copolymers using this agent via a one-step process, there should be no interactions between the two functional groups, catalysts or initiators, and monomers. In addition, the two polymerizations should proceed in a controlled manner at the same reaction temperature.13 Because of these limitations, most of the block copolymers synthesized using hetero double-head agents to date are prepared by a sequential reaction. This section reviews polymers synthesized using asymmetrical double-head agents with an emphasis on materials useful in biomedical applications. ### ATRP Initiator-based Double-head Agents The Maynard group employed a series of ATRP initiator-based doublehead agents in an elegant approach to prepare polymer-protein conjugates.14-16 In one study, a pyridyl disulfide (PDS)-modified ATRP initiator was used to prepare a well-defined poly(2-hydroxyethyl methacrylate) (P(HEMA)) that was then conjugated to bovine serum albumin.14 In the second report, a biotinylated ATRP initiator was bound to streptavidin and used as a protein macroinitiator for polymerization of NIPAAm.15 Finally, peptide macroinitiators were synthesized using amino acids with side-chain modified-ATRP initiators in solid-phase peptide synthesis. These macroinitiators were used to synthesize peptide-polymer (e.g., PHEMA and glycopolymers) conjugates exhibiting narrow molecular weight distributions, resulting in well-defined materials.16 Among the click chemistry group of reactions for facile coupling, the CuI-catalyzed azide-alkyne cycloaddition (CuAAC “click”)17 has received the most attention and has been increasingly employed in polymer functionalization and materials synthesis, especially in conjunction with controlled radical polymerization methods.18 The CuAAC “click” is particularly well-suited for pairing with ATRP, due to the ease of incorporating clickable functionality into polymers prepared by ATRP and the use of the same catalyst system in each process. The combination of these two powerful techniques has greatly expanded the range of available materials. In one example, the Grayson group used an alkynefunctionalized ATRP initiator to prepare cyclic polymers.19 Following this methodology, Wei et al. prepared cyclic cationic polymers for nucleic acid delivery and demonstrated that the cyclic polymers were just as effective in gene transfer but less cytotoxic to cultured mammalian cells compared with their linear analogues.20 Another useful agent was prepared by the Gohy and Fustin group; this ATRP initiator contained an o-nitrobenzyl ester photocleavable junction and an alkyne group for the CuAAC “click” reaction.21 Oh et al. prepared a reducible version of a double-head initiator (HO-SSiBuBr)22 for integrated ATRP and ROP techniques (HO-iBuBr, Prod. No. [723150](https://www.sigmaaldrich.com/US/en/product/aldrich/723150))23 introduced by the Matyjaszewski group. In the presence of OH-SS-iBuBr, both ROP of lactide and ATRP of oligo(ethylene glycol) methyl ether methacrylate (OEGMA) were controlled, resulting in welldefined biodegradable block copolymers of PLA-SS-POEGMA with narrow MWD (<1.2). Aqueous micellization of PLA-SS-POEGMA resulted in core/shell micelles with SS links positioned at the interface between PLA cores and POEGMA coronas. In reducing environments such as the cytosol, POEGMA coronas were shed from the PLA cores, causing the precipitation of PLA core due to the loss of colloidal stability. These results, combined with non-cytotoxicity, indicated that the biodegradable PLA-based sheddable micelles could be useful as novel drug delivery systems for intracellular drug delivery. Using this same double-head agent, Wei et al. synthesized a ternary, amphiphilic block copolymer PCL-SS-P((GMA-TEPA)-st-OEGMA) containing a sheddable hydrophobic PCL block, pH-sensitive oligoamine tetraethylenepentamine (TEPA)-decorated poly(glycidyl methacrylate) (PGMA) block, and a hydrophilic OEGMA segment.24 The sheddable hydrophobic PCL block was synthesized by ROP using the reducible double-head initiator HO-SS-iBuBr and then used as a macroinitiator for subsequent ATRP of GMA and OEGMA. This new block statistical copolymer combines reversible hydrophobization for enhanced particle stability in extracellular environments and statistical hydrophilization for efficient plasmid and siRNA release inside cells. This polymer was shown to be effective for in vivo gene transfer to mouse brain due to its multifunctional and bioresponsive properties. ### RAFT CTA-based Double-head Agents RAFT CTA-based double-head agents can be used to generate polymers with reactive termini for a variety of biomedical applications, including protein conjugation, nanoparticle grafting, and biofunctionalization. Zhao’s group reported novel strategies for combining RAFT polymerization and CuAAC “click” by using either a Z-azide-functionalized RAFT CTA, S-azidepropoxycarbonylethyl S’-methoxycarbonylphenylmethyl trithiocarbonate (AMP)25 or a Z-alkyne-functionalized RAFT CTA26 to prepare homopolymers and multiblock copolymers. These polymers were used for grafting to silica nanoparticles. The Maynard group designed a PDS-functionalized trithiocarbonate CTA for the preparation of protein-polymer conjugates.27 Covalent conjugation of a RAFTsynthesized heparin-mimicking polymer, poly(sodium 4-styrenesulfonateco-poly(ethylene glycol) methyl ether methacrylate) to basic fibroblast growth factor (bFGF) significantly enhanced protein stability under a variety of environmentally and therapeutically relevant stressors—such as heat, mild and harsh acidic conditions, storage and proteolytic degradation—different from native bFGF. Advanced polymer structures also can be prepared using RAFT CTAbased double-head agents. Youk and co-workers synthesized welldefined block copolymers using 4-cyano-4-(dodecylsulfanylthiocarbonyl) sulfanylpentanol (CDP) as a dual initiator for RAFT polymerization and ROP in a one-step process.28 In one example, block copolymers with one block synthesized by RAFT polymerization of vinyl monomers and a second block synthesized by ROP of cyclic monomers were prepared in a one-step synthesis with selective catalysts for ROP that did not interfere with RAFT polymerization. RAFT polymerization in the presence of a compound capable of both reversible chain transfer through a thiocarbonylthio moiety and propagation via a vinyl group leads to highly branched copolymers. Sumerlin et al. synthesized an acryloyl trithiocarbonate and performed copolymerization with NIPAAm in ratios selected to control the distribution and length of branches in the resulting thermo-responsive copolymers.29 Retention of the active thiocarbonylthio compound during the polymerization was evidenced by a successfully subsequent chain extension of the resulting branched PNIPAAm macro-CTA by a further RAFT polymerization of a second monomer. This approach could be extendable to the synthesis of a variety of branched stimuli-responsive copolymers with a high concentration of sulfur-containing end groups that can facilitate polyvalent bioconjugation or surface immobilization. ### RAFT–ATRP Double-head Agents Wei et al. introduced a reducible RAFT–ATRP double-head agent for the synthesis of peptide-functionalized copolymers with sheddable shielding blocks for nucleic acid delivery applications.30 An optimized reduction-responsive cationic block copolymer, P(OEGMA)-SS-P(GMATEPA), was synthesized using this double-head agent by a combination of RAFT polymerization of OEGMA and ATRP of glycidyl methacrylate (GMA), followed by post-polymerization decoration of reactive epoxy groups in the P(GMA) block by tetraethylenepentamine (TEPA). The resulting diblock copolymer showed well-controlled composition with narrow MWD and was easily modified with a neuron targeting peptide, Tet1, at the outer corona by a Michael-type addition to the free thiols generated by aminolysis of the dithioester end group. The final polymer formed salt-stable particles amenable for in vivo use while maintaining high transfection efficiency, likely due to its multifunctional capabilities of targeting, endosomal escape, and deshielding and cargo release endowed by the Tet1 peptide, protonable TEPA amines, and reducible backbone structure, respectively (__Figure 2__). Thus, due to the combined properties of targeting and shielding, this block copolymer was shown to retain high transfection efficiencies comparable to the analogous homopolycation vectors for targeted gene delivery. The RAFT-ATRP double-head agent, therefore, provides a versatile means for preparing various types of multifunctional drug and gene delivery vehicles. ![Pendant oligoamine side chain](https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/images/technical-documents/articles/materials-science-and-engineering/polymer-synthesis/Pendant-oligoamine-side-chain/Pendant-oligoamine-side-chain.jpg "Pendant-oligoamine-side-chain") __Figure 2.__Illustration for P(OEGMA)15-SS-P(GMA-TEPA)50 cationic polymer, DNA condensation, cell binding, endocytosis, and proposed route for subsequent reduction-triggered intracellular unpackage of pDNA. Copyright (2012) American Chemical Society.30 ## Conclusion and Perspective The design and development of various double-head agents represent an elegant approach toward advanced materials design. With double-head agents, different polymerizations/reactions can be carried out without intermediate transformation and functionalization steps, sometimes even in a concurrent manner, significantly simplifying the traditional techniques for the preparation of block copolymers as well as generating a broad spectrum of novel block copolymers with fascinating properties based on diverse monomers. It is not surprising that the last decade has seen a tremendous growth in the development of such agents. It is worth noting that the disulfide bond has attracted most of the attention, and it has been repeatedly employed as the degradable link in a double-head agent due to the excellent compatibility of disulfide with CLP processes, the reversible degradation and formation of the disulfide bond under mild conditions, and also the biological relevance of disulfides. Future research concerning the use of other stimuli-responsive links, such as acidic pH, temperature, enzyme-responsive substrates, and photo-sensitive bridges for the preparation of degradable double-head agents will be a hot topic and remains to be explored. Looking to the future, much exciting work is expected to develop in the new field of advanced biomaterials prepared using various double-head agents. ## Materials Sorry, an unexpected error has occurred Response not successful: Received status code 500 ### References 1\. Feng J, Zhuo R, Zhang X. 2012. Construction of functional aliphatic polycarbonates for biomedical applications. Progress in Polymer Science. 37(2):211-236. [https://doi.org/10.1016/j.progpolymsci.2011.07.008](https://doi.org/10.1016/j.progpolymsci.2011.07.008) 2\. Nicolas J, Guillaneuf Y, Lefay C, Bertin D, Gigmes D, Charleux B. 2013. Nitroxide-mediated polymerization. Progress in Polymer Science. 38(1):63-235. [https://doi.org/10.1016/j.progpolymsci.2012.06.002](https://doi.org/10.1016/j.progpolymsci.2012.06.002) 3\. Siegwart DJ, Oh JK, Matyjaszewski K. 2012. ATRP in the design of functional materials for biomedical applications. Progress in Polymer Science. 37(1):18-37. [https://doi.org/10.1016/j.progpolymsci.2011.08.001](https://doi.org/10.1016/j.progpolymsci.2011.08.001) 4\. Gregory A, Stenzel MH. 2012. Complex polymer architectures via RAFT polymerization: From fundamental process to extending the scope using click chemistry and nature's building blocks. Progress in Polymer Science. 37(1):38-105. [https://doi.org/10.1016/j.progpolymsci.2011.08.004](https://doi.org/10.1016/j.progpolymsci.2011.08.004) 5\. Chen J, Liu M, Gong H, Cui G, Lü S, Gao C, Huang F, Chen T, Zhang X, Liu Z. 2013. Synthesis of linear amphiphilic tetrablock quaterpolymers with dual stimulus response through the combination of ATRP and RAFT by a click chemistry site transformation approach. Polym. Chem.. 4(6):1815. [https://doi.org/10.1039/c2py20946b](https://doi.org/10.1039/c2py20946b) 6\. Such GK, Johnston AP, Liang K, Caruso F. 2012. Synthesis and functionalization of nanoengineered materials using click chemistry. Progress in Polymer Science. 37(7):985-1003. [https://doi.org/10.1016/j.progpolymsci.2011.12.002](https://doi.org/10.1016/j.progpolymsci.2011.12.002) 7\. Roth PJ, Boyer C, Lowe AB, Davis TP. 2011. RAFT Polymerization and Thiol Chemistry: A Complementary Pairing for Implementing Modern Macromolecular Design. Macromol. Rapid Commun.. 32(15):1123-1143. [https://doi.org/10.1002/marc.201100127](https://doi.org/10.1002/marc.201100127) 8\. Tsarevsky NV, Matyjaszewski K. 2002. Reversible Redox Cleavage/Coupling of Polystyrene with Disulfide or Thiol Groups Prepared by Atom Transfer Radical Polymerization. Macromolecules. 35(24):9009-9014. [https://doi.org/10.1021/ma021061f](https://doi.org/10.1021/ma021061f) 9\. Li C, Madsen J, Armes SP, Lewis AL. 2006. A New Class of Biochemically Degradable, Stimulus-Responsive Triblock Copolymer Gelators. Angew. Chem. Int. Ed.. 45(21):3510-3513. [https://doi.org/10.1002/anie.200600324](https://doi.org/10.1002/anie.200600324) 10\. Syrett JA, Mantovani G, Barton WRS, Price D, Haddleton DM. 2010. Self-healing polymers prepared via living radical polymerisation. Polym. Chem.. 1(1):102. [https://doi.org/10.1039/b9py00316a](https://doi.org/10.1039/b9py00316a) 11\. Jiang X, Zhang M, Li S, Shao W, Zhao Y. 2012. Facile synthesis and versatile topological transformation of mono-cleavable symmetric starlike terpolymers. Chem. Commun.. 48(79):9906. [https://doi.org/10.1039/c2cc35275c](https://doi.org/10.1039/c2cc35275c) 12\. Sun H, Guo B, Cheng R, Meng F, Liu H, Zhong Z. 2009. Biodegradable micelles with sheddable poly(ethylene glycol) shells for triggered intracellular release of doxorubicin. Biomaterials. 30(31):6358-6366. [https://doi.org/10.1016/j.biomaterials.2009.07.051](https://doi.org/10.1016/j.biomaterials.2009.07.051) 13\. Bernaerts KV, Du Prez FE. 2006. Dual/heterofunctional initiators for the combination of mechanistically distinct polymerization techniques. Progress in Polymer Science. 31(8):671-722. [https://doi.org/10.1016/j.progpolymsci.2006.08.007](https://doi.org/10.1016/j.progpolymsci.2006.08.007) 14\. Bontempo D, Heredia KL, Fish BA, Maynard HD. 2004. Cysteine-Reactive Polymers Synthesized by Atom Transfer Radical Polymerization for Conjugation to Proteins. J. Am. Chem. Soc.. 126(47):15372-15373. [https://doi.org/10.1021/ja045063m](https://doi.org/10.1021/ja045063m) 15\. Bontempo D, Maynard HD. 2005. Journal of the American Chemical Society.(127):6508–6509. 16\. Broyer RM, Quaker GM, Maynard HD. 2008. Designed Amino Acid ATRP Initiators for the Synthesis of Biohybrid Materials. J. Am. Chem. Soc.. 130(3):1041-1047. [https://doi.org/10.1021/ja0772546](https://doi.org/10.1021/ja0772546) 17\. Kolb HC, Finn MG, Sharpless KB. 2001. Angewandte Chemie International Edition.(40):2004–2021. 18\. Barner-Kowollik C, Du?Prez FE, Espeel P, Hawker CJ, Junkers T, Schlaad H, Van?Camp W. 2011. ?Clicking? Polymers or Just Efficient Linking: What Is the Difference?. Angew. Chem. Int. Ed.. 50(1):60-62. [https://doi.org/10.1002/anie.201003707](https://doi.org/10.1002/anie.201003707) 19\. Laurent BA, Grayson SM. 2006. An Efficient Route to Well-Defined Macrocyclic Polymers via ?Click? Cyclization. J. Am. Chem. Soc.. 128(13):4238-4239. [https://doi.org/10.1021/ja0585836](https://doi.org/10.1021/ja0585836) 20\. Wei H, Chu DSH, Zhao J, Pahang JA, Pun SH. 2013. Synthesis and Evaluation of Cyclic Cationic Polymers for Nucleic Acid Delivery. ACS Macro Lett.. 2(12):1047-1050. [https://doi.org/10.1021/mz400560y](https://doi.org/10.1021/mz400560y) 21\. Schumers J, Gohy J, Fustin C. A versatile strategy for the synthesis of block copolymers bearing a photocleavable junction. Polym. Chem.. 1(2):161-163. [https://doi.org/10.1039/b9py00218a](https://doi.org/10.1039/b9py00218a) 22\. Khorsand Sourkohi B, Cunningham A, Zhang Q, Oh JK. 2011. Biodegradable Block Copolymer Micelles with Thiol-Responsive Sheddable Coronas. Biomacromolecules. 12(10):3819-3825. [https://doi.org/10.1021/bm2011032](https://doi.org/10.1021/bm2011032) 23\. Jakubowski W, Lutz J, Slomkowski S, Matyjaszewski K. 2005. Block and random copolymers as surfactants for dispersion polymerization. I. Synthesis via atom transfer radical polymerization and ring-opening polymerization. J. Polym. Sci. A Polym. Chem.. 43(7):1498-1510. [https://doi.org/10.1002/pola.20629](https://doi.org/10.1002/pola.20629) 24\. Wei H, Volpatti LR, Sellers DL, Maris DO, Andrews IW, Hemphill AS, Chan LW, Chu DSH, Horner PJ, Pun SH. 2013. Dual Responsive, Stabilized Nanoparticles for Efficient In?Vivo Plasmid Delivery. Angew. Chem. Int. Ed.. 52(20):5377-5381. [https://doi.org/10.1002/anie.201301896](https://doi.org/10.1002/anie.201301896) 25\. Huang Y, Hou T, Cao X, Perrier S, Zhao Y. 2010. Synthesis of silica-polymer hybrids by combination of RAFT polymerization and azide-alkyne cycloaddition ?click? reactions. Polym. Chem.. 1(10):1615. [https://doi.org/10.1039/c0py00165a](https://doi.org/10.1039/c0py00165a) 26\. Zhao G, Zhang P, Zhang C, Zhao Y. Facile synthesis of highly pure block copolymers by combination of RAFT polymerization, click reaction and de-grafting process. Polym. Chem.. 3(7):1803-1812. [https://doi.org/10.1039/c1py00396h](https://doi.org/10.1039/c1py00396h) 27\. Nguyen TH, Kim S, Decker CG, Wong DY, Loo JA, Maynard HD. 2013. A heparin-mimicking polymer conjugate stabilizes basic fibroblast growth factor. Nature Chem. 5(3):221-227. [https://doi.org/10.1038/nchem.1573](https://doi.org/10.1038/nchem.1573) 28\. Kang HU, Yu YC, Shin SJ, Youk JH. 2013. One?step synthesis of block copolymers using a hydroxyl?functionalized trithiocarbonate RAFT agent as a dual initiator for RAFT polymerization and ROP. J. Polym. Sci. A Polym. Chem.. 51(4):774-779. [https://doi.org/10.1002/pola.26464](https://doi.org/10.1002/pola.26464) 29\. Vogt AP, Sumerlin BS. 2008. Tuning the Temperature Response of Branched Poly(N-isopropylacrylamide) Prepared by RAFT Polymerization. Macromolecules. 41(20):7368-7373. [https://doi.org/10.1021/ma801256k](https://doi.org/10.1021/ma801256k) 30\. Wei H, Schellinger JG, Chu DSH, Pun SH. 2012. Neuron-Targeted Copolymers with Sheddable Shielding Blocks Synthesized Using a Reducible, RAFT-ATRP Double-Head Agent. J. Am. Chem. Soc.. 134(40):16554-16557. [https://doi.org/10.1021/ja3085803](https://doi.org/10.1021/ja3085803) __Related Articles__ - [Carbon Nanofiber Applications & Properties](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/materials-science-and-engineering/batteries-supercapacitors-and-fuel-cells/carbon-nanofibers) - [Nano Minerals: Nanoclays](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/materials-science-and-engineering/bioelectronics/nano-minerals-nanoclays) - [Universal Platform for Surface Modification Employing Grafted Polymer Layers](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/materials-science-and-engineering/biosensors-and-imaging/universal-platform) - [Continuous Flow Manufacturing for Monomer Synthesis](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/materials-science-and-engineering/contact-lens-and-dental-manufacturing/continuous-flow-manufacturing) - [High-Purity Monomers & Polymers for Ophthalmic Applications](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/materials-science-and-engineering/contact-lens-and-dental-manufacturing/high-purity-monomers-and-polymers-for-ophthalmic-applications) - [Innovative Materials for Glass Ionomer Cements (GICs): Dental Applications](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/materials-science-and-engineering/contact-lens-and-dental-manufacturing/innovative-ionomers-for-dental-applications) - [The Progress in Development of Dental Restorative Materials](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/materials-science-and-engineering/contact-lens-and-dental-manufacturing/the-progress-in-development) - [Click Chemistry in Biomaterials Science](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/materials-science-and-engineering/drug-delivery/click-chemistry) - [View More](https://www.sigmaaldrich.com/US/en/search/facet-search?focus=sitecontent&term=facet-search) __Related Product Categories__ - [Polymerization Tools](https://www.sigmaaldrich.com/US/en/products/materials-science/biomedical-materials/polymerization-tools) Top __Sign In To Continue__ To continue reading please sign in or create an account. Sign In__Don't Have An Account?__Register Support[Customer Support](https://www.sigmaaldrich.com/US/en/support/customer-support)[Contact Us](https://www.sigmaaldrich.com/US/en/collections/offices)[FAQ](https://maestro.my.site.com/knowledgeportal/s/)[Safety Data Sheets (SDS)](https://www.sigmaaldrich.com/US/en/documents-search?tab=sds)[Certificates (COA/COO)](https://www.sigmaaldrich.com/US/en/documents-search?tab=coa)[Quality & Regulatory](https://www.sigmaaldrich.com/US/en/life-science/quality-and-regulatory-management)[Calculators & Apps](https://www.sigmaaldrich.com/US/en/support/calculators-and-apps)[Webinars](https://www.sigmaaldrich.com/US/en/collections/webinars) Orders[Order Lookup](https://www.sigmaaldrich.com/US/en/order-lookup)[Quick Order](https://www.sigmaaldrich.com/US/en/quick-order)[Custom Products](https://www.sigmaaldrich.com/US/en/services/custom-products)[eCommerce Solutions](https://www.sigmaaldrich.com/US/en/life-science/ecommerce/ecommerce-solutions) Company[About Us](https://www.sigmaaldrich.com/US/en/life-science/about-us)[Responsibility](https://www.sigmaaldrich.com/US/en/life-science/ssbi)[Events](https://www.sigmaaldrich.com/US/en/collections/events)[Press Releases](https://www.sigmaaldrich.com/US/en/collections/press)[Programs](https://www.sigmaaldrich.com/US/en/life-science/partnership-programs)[Careers](https://careers.merckgroup.com/global/en)[Offices](https://www.sigmaaldrich.com/US/en/collections/offices) Social Media [![LinkedIn icon](https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/images/icons/linkedin.svg)](https://www.linkedin.com/company/milliporesigma) [![X icon](https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/images/icons/x-icon.svg)](https://x.com/MilliporeSigma) [![Facebook Icon](https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/images/icons/facebook.svg)](https://www.facebook.com/MilliporeSigma) [![Instagram Icon](https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/images/icons/instagram.svg)](https://www.instagram.com/milliporesigma/) [![YouTube Icon](https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/images/icons/youtube.svg)](https://www.youtube.com/@milliporesigma2407/featured) MilliporeSigma __Research. Development. Production.__ We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production. [![Vibrant M string](https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/images/icons/vibrant-m-string-1-rrvcrp.svg)](https://www.sigmaaldrich.com/US/en) [Sigma-Aldrich® Solutions](https://www.sigmaaldrich.com/US/en/life-science/sigma-aldrich)[BioReliance® Solutions](https://www.sigmaaldrich.com/US/en/life-science/bioreliance)[Millipore® Solutions](https://www.sigmaaldrich.com/US/en/life-science/millipore)[SAFC® Solutions](https://www.sigmaaldrich.com/US/en/life-science/safc)[Milli-Q® Solutions](https://www.sigmaaldrich.com/US/en/life-science/milliq)[Supelco® Solutions](https://www.sigmaaldrich.com/US/en/life-science/supelco) © 2026 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved, including Text and Data Mining for AI training and similar technologies. Reproduction of any materials from the site is strictly forbidden without permission. [Site Use Terms](https://www.sigmaaldrich.com/US/en/life-science/legal/site-use-terms)|[Privacy Policy](https://www.sigmaaldrich.com/US/en/life-science/legal/privacy-statement)|[General Terms and Conditions of Sale](https://www.sigmaaldrich.com/US/en/life-science/legal/terms-and-conditions)|[Copyright Consent](https://www.sigmaaldrich.com/US/en/life-science/legal/copyright-consent) |[Site Map](https://www.sigmaaldrich.com/US/en/site-map) An unknown error has occured. - English - EN - Español - ES [Learn More](https://www.sigmaaldrich.com) - Products - [Analytical Chemistry](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry) - [Analytical Chromatography](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-chromatography) - [Analytical Syringes](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-chromatography/analytical-syringes) - [Analytical Vials](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-chromatography/analytical-vials) - [Carbon Adsorbents](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-chromatography/carbon-adsorbents) - [Chromatography Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/chromatography-standards) - [GC Columns, Accessories & Adsorbents](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-chromatography/gc-columns-accessories-and-adsorbents) - [HPLC Buffers](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-chromatography/hplc-buffers) - [HPLC Columns](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-chromatography/hplc-columns) - [LPLC Media & Accessories](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-chromatography/lplc-media-and-accessories) - [Purge Traps](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-sample-preparation/purge-traps) - [Solvents](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-chromatography/solvents) - [TLC Plates & Adsorbents](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-chromatography/tlc-plates-and-adsorbants) - [Analytical Reagents](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-reagents) - [Acids](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-chemicals/acids) - [Analytical Syringes](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-chromatography/analytical-syringes) - [Analytical Vials](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-chromatography/analytical-vials) - [Caustic Alkalis & Bases](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-chemicals/caustic-alkalis-and-bases) - [Chromatography & Spectroscopy Reagents](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-reagents/chromatography-spectroscopy-reagents) - [Colorimetric & Titrimetric Test Kits](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/photometry-and-rapid-chemical-testing/colorimetric-and-titrimetric-test-kits) - [Indicators](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-reagents/indicators) - [Karl Fischer Reagents](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-reagents/karl-fischer-reagents) - [Karl Fischer Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/karl-fischer-standards) - [Metals](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-chemicals/metals) - [pH Test Strips, pH Papers, Readers & Accessories](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/photometry-and-rapid-chemical-testing/ph-test-strips-paper-readers-and-accessories) - [Salts](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-chemicals/salts) - [Solvents](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-chromatography/solvents) - [Spectroquant Photometry Instruments, Kits, & Accessories](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/photometry-and-rapid-chemical-testing/photometry-instruments-kits-and-accessories) - [Test Strips, Papers & Readers](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/photometry-and-rapid-chemical-testing/test-strips-papers-and-readers) - [Titration Reagents](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-reagents/titration-reagents) - [Analytical Sample Preparation](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-sample-preparation) - [Air Monitoring Devices & Tubes](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-sample-preparation/air-monitoring-devices-and-tubes) - [Laboratory Filter Holders](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-filter-holders) - [Millipore<sup>®</sup> Lab Filter Membranes](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-filter-membranes/millipore-filter-membranes) - [Millex<sup>®</sup> Syringe Filters](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-syringe-filters/millex-syringe-filters) - [Purge Traps](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-sample-preparation/purge-traps) - [Solid Phase Extraction (SPE) & QuEChERS](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-sample-preparation/spe-and-quechers) - [Solid Phase Micro-Extraction (SPME)](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-sample-preparation/spme-fibers-and-accessories) - [Supported Liquid Extraction (SLE) Columns, Resins & Accessories](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-sample-preparation/sle-columns-resins-and-accessories) - [Lab Safety](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-safety) - [Labware Detergents & Cleaners](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-safety/cleaning-detergents) - [Safe Handling](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-safety/safe-handling) - [Safety Accessories](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-safety/safety-accessories) - [Spillage Absorption](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-safety/spillage-absorption) - [Photometry & Rapid Chemical Testing](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/photometry-and-rapid-chemical-testing) - [Colorimetric & Titrimetric Test Kits](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/photometry-and-rapid-chemical-testing/colorimetric-and-titrimetric-test-kits) - [pH Test Strips, pH Papers, Readers & Accessories](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/photometry-and-rapid-chemical-testing/ph-test-strips-paper-readers-and-accessories) - [Photometry Instruments, Test Kits & Accessories](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/photometry-and-rapid-chemical-testing/photometry-instruments-kits-and-accessories) - [Test Strips, Papers & Readers](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/photometry-and-rapid-chemical-testing/test-strips-papers-and-readers) - [Turbidimetric Analysis](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/photometry-and-rapid-chemical-testing/turbiquant-turbidimetric-analysis) - [Reference Materials](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials) - [Amino Acid, Peptide & Protein Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/amino-acid-peptide-and-protein-standards) - [Biomarker & Metabolite Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/biomarker-and-metabolite-standards) - [Cannabis Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/cannabis-standards) - [Carbohydrate Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/carbohydrate-standards) - [Certified Reference Materials](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/certified-reference-materials) - [Chromatography Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/chromatography-standards) - [Food Additive Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/food-additive-standards) - [Food & Cosmetic Component Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/food-and-cosmetic-component-standards) - [ICP & AAS Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/icp-and-aas-standards) - [Inorganic Elemental Impurity Mix Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/inorganic-elemental-impurity-mix-standards) - [Ion Chromatography Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/ion-chromatography-standards) - [Karl Fischer Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/karl-fischer-standards) - [Lipid Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/lipid-standards) - [Matrix Materials Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/matrix-materials-standards) - [Microbiology Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/microbiology-standards) - [Organic Pollutant Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/organic-pollutant-standards) - [Pesticide Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/pesticide-standards) - [Petrochemical Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/petrochemical-standards) - [Pharma Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/pharma-secondary-standards) - [Pharmaceuticals, Illicit Drugs & Diagnostic Biomarkers](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/pharmaceuticals-illicit-drugs-and-diagnostic-biomarkers) - [Pharmacopeia & Metrological Institutes Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/pharmacopeia-and-metrological-institutes-standards) - [Physical & Chemical Properties Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/physical-property-standards) - [Phytochemical Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/phytochemical-standards) - [Vitamin Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/vitamin-standards) - [Cell Culture & Analysis](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis) - [3D Cell Culture](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/3d-cell-culture) - [Hydrogels](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/3d-cell-culture/hydrogels) - [Organoids](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/3d-cell-culture/organoids) - [Scaffolds](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/3d-cell-culture/scaffolds) - [Animal Component Free Cell Culture Reagents](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/animal-component-free-cell-culture-reagents) - [Cell Analysis](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-analysis) - [Cell Counting Equipment](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-analysis/cell-counting-equipment) - [Cell Health Analysis](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-analysis/cell-health-analysis) - [Cell Imaging Instruments](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-analysis/cell-imaging-instruments) - [Cell Isolation Kits](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-analysis/cell-isolation-kits) - [Cell Migration & Invasion Assays](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-analysis/cell-migration-and-invasion-assays) - [Live Cell Imaging Reagents](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-analysis/live-cell-imaging-reagents) - [Cell Culture Media & Buffers](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-media-and-buffers) - [Bioprocessing Cell Culture Media](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-cell-culture/bioprocessing-cell-culture-media) - [Bioprocessing Liquid Cell Culture Media & Buffers](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-formulation-raw-materials/liquid-cell-culture-media-buffers) - [Classical Media & Buffers](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-media-and-buffers/classical-media-and-buffers) - [Custom GMP Cell Culture Media](https://www.sigmaaldrich.com/US/en/services/custom-products/custom-gmp-cell-culture-products) - [Plant Culture Media](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-media-and-buffers/plant-culture-media) - [Cell Culture Supplements & Reagents](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents) - [Albumins & Transport Proteins](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents/albumins-and-transport-proteins) - [Amino Acids](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/amino-acids) - [Antibiotics](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/antibiotics) - [Attachment Factors](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents/attachment-factors) - [Bioprocessing Recombinant Supplements](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-cell-culture/recombinant-supplements) - [Carbohydrates](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/carbohydrates) - [Cell Dissociation Reagents](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents/cell-dissociation-reagents) - [Cell Freezing Reagents](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents/cell-freezing-reagents) - [FBS](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents/fbs) - [Growth Factors & Cytokines](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents/growth-factors-and-cytokines) - [Hormones](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents/hormones) - [Human Serum](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents/human-serum) - [(Other) Sera](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents/other-sera) - [Plant Culture Reagents](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents/plant-culture-reagents) - [Sera](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents/sera) - [Supplements for Cell Culture](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents/supplements) - [Vitamins](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/vitamins) - [Cell Lines & Specialty Cell Culture](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-lines-and-specialty-cell-culture) - [Bioprocessing Cell Lines](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-cell-culture/bioprocessing-cell-lines) - [Mammalian Cell Lines](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-lines-and-specialty-cell-culture/mammalian-cell-lines) - [Mouse Embryo Media](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-lines-and-specialty-cell-culture/mouse-embryo-media) - [Primary Cells](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-lines-and-specialty-cell-culture/primary-cells) - [Stem Cells](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-lines-and-specialty-cell-culture/stem-cells) - [Sterile Lab Media Filtration & Cultureware](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/sterile-lab-media-filtration-and-cultureware) - [Cell Culture Supplies](https://www.sigmaaldrich.com/US/en/products/labware/cell-culture-and-cryogenics/cell-culture-supplies) - [Millex<sup>®</sup> Syringe Filters](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-syringe-filters/millex-syringe-filters) - [Millicell<sup>®</sup> Cell Culture Inserts & Plates](https://www.sigmaaldrich.com/US/en/products/labware/cell-culture-and-cryogenics/millicell-cell-culture-inserts-and-plates) - [Millipore<sup>®</sup> Sterile Filters](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/sterile-lab-media-filtration-and-cultureware/millipore-sterile-filters) - [MultiScreen<sup>®</sup> Filter Plates](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/sterile-lab-media-filtration-and-cultureware/multiscreen-filter-plates) - [Stericup<sup>®</sup> Vacuum Filters](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/sterile-lab-media-filtration-and-cultureware/stericup-vacuum-filtration) - [Chemistry & Biochemicals](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals) - [Amino Acids, Resins & Reagents for Peptide Synthesis](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/amino-acids-resins-and-reagents-for-peptide-synthesis) - [Biochemicals](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals) - [Agarose](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/agarose) - [Amino Acids](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/amino-acids) - [Antibiotics](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/antibiotics) - [Avanti Research™, A Croda Brand](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/avanti-research) - [Biological Buffers](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/biological-buffers) - [Carbohydrates](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/carbohydrates) - [Chelating & Reducing Agents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/chelating-reducing-agents) - [Coenzymes](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/coenzymes) - [Detergents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/detergents) - [Lipids](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/lipids) - [Glycoconjugates](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/glycoconjugates) - [High-Purity Biochemicals & Reagents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/high-purity-biochemicals-and-reagents) - [Metabolism Assay Kits](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/metabolism-assay-kits) - [Metabolite Libraries](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/metabolite-libraries) - [Natural Products](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/natural-products) - [Nucleosides & Nucleotides](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/nucleosides-and-nucleotides) - [Vitamins](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/vitamins) - [Building Blocks](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/building-blocks) - [Fluorinated Building Blocks](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/building-blocks/fluorinated-building-blocks) - [Halogenated Heterocycles](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/building-blocks/halogenated-heterocycles) - [Heterocyclic Building Blocks](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/building-blocks/heterocyclic-building-blocks) - [Organic Building Blocks](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/building-blocks/organic-building-blocks) - [Catalysts](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts) - [Buchwald Catalysts & Ligands](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts/buchwald-catalysts-and-ligands) - [C-H Activation Catalysts](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts/c-h-activation-catalysts) - [Chiral Catalysts & Ligands](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts/chiral-catalysts-and-ligands) - [Cross-Coupling Catalysts](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts/cross-coupling-catalysts) - [Hydrogenation Catalysts](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts/hydrogenation-catalysts) - [Inorganic Catalysts](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts/inorganic-catalysts) - [NHC Ligands & Complexes](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts/nhc-ligands-and-complexes) - [Olefin Metathesis](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts/olefin-metathesis) - [Organocatalysts](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts/organocatalysts) - [Phase-Transfer Catalysts](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts/phase-transfer-catalysts) - [Phosphine Ligands](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts/phosphine-ligands) - [Photocatalysts](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts/photocatalysts) - [Transition Metal Catalysts](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts/transition-metal-catalysts) - [Chemical Biology](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-biology) - [Carbohydrates](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/carbohydrates) - [Chemical Biology Tools](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-biology/chemical-biology-tools) - [Click Chemistry Reagents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-biology/click-chemistry-reagents) - [Crosslinkers](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-biology/crosslinkers) - [Protein Degrader Building Blocks](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-biology/protein-degrader-building-blocks) - [Chemical Synthesis](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis) - [Boronic Acids & Derivatives](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis/boronic-acids-and-derivatives) - [C-C Bond Forming Reagents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis/c-c-bond-forming-reagents) - [Chiral Auxiliaries](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis/chiral-auxiliaries) - [Coupling Reagents & Nucleosides](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis/coupling-reagents-and-nucleosides) - [Grignard Reagents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis/grignard-reagents) - [Halogenation Reagents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis/halogenation-reagents) - [Organoaluminum Reagents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis/organoaluminum-reagents) - [Organolithium Reagents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis/organolithium-reagents) - [Organosilicon Reagents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis/organosilicon-reagents) - [Organotin Reagents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis/organotin-reagents) - [Organozinc Reagents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis/organozinc-reagents) - [Oxidation Reagents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis/oxidation-reagents) - [Protection/Deprotection Reagents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis/protection-deprotection-reagents) - [Reducing Agents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis/reducing-agents) - [Flavors & Fragrances](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/flavors-and-fragrances) - [Formulation](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation) - [Biomolecule Formulation](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/biomolecule-formulation) - [Granulated Materials](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/granulated-materials) - [Liquid Formulation](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/liquid-formulation) - [Protein Stabilizers](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/protein-stabilizers) - [Semisolid Formulation](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/semisolid-formulation) - [Solid Formulation](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/solid-formulation) - [Lab Chemicals](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-chemicals) - [Absorbents & Adsorbents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-chemicals/absorbents-and-adsorbents) - [Acids](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-chemicals/acids) - [Caustic Alkalis & Bases](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-chemicals/caustic-alkalis-and-bases) - [Drying Agents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-chemicals/drying-agents) - [Filter Aids & Filter Media](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-chemicals/filter-aids-filter-media) - [Indicators](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-reagents/indicators) - [Metals](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-chemicals/metals) - [Salts](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-chemicals/salts) - [Solvents](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-chromatography/solvents) - [Lab Safety](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-safety) - [Labware Detergents & Cleaners](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-safety/cleaning-detergents) - [Safe Handling](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-safety/safe-handling) - [Safety Accessories](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-safety/safety-accessories) - [Spillage Absorption](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-safety/spillage-absorption) - [Stable Isotopes](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/stable-isotopes) - [Synthesis Enabling Tools](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/synthesis-enabling-tools) - [Automated Chemical Synthesis](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/synthesis-enabling-tools/automated-chemical-synthesis) - [High Throughput Screening](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/synthesis-enabling-tools/high-throughput-screening-platform) - [Photoreactors](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/synthesis-enabling-tools/photoreactors) - [Electrosynthesis](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/synthesis-enabling-tools/electrosynthesis-platform) - [Clinical & Diagnostics](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics) - [Blood Typing](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/blood-typing) - [Blood Typing Finished Reagents](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/blood-typing/blood-typing-finished-reagents) - [Blood Typing Intermediates For Further Manufacturing Use (FFMU)](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/blood-typing/blood-typing-intermediates) - [Cell Marque™](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/cell-marque) - [Cell Marque™ Control Slides](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/cell-marque/cell-marque-control-slides) - [Cell Marque™ Detection Systems & Ancillary Reagents](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/cell-marque/cell-marque-detection-systems-and-ancillary-reagents) - [Cell Marque™ Primary Antibodies](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/cell-marque/cell-marque-ihc-antibodies) - [Lateral Flow Membranes](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/lateral-flow-membranes) - [ProClin™ Preservatives](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/proclin-preservatives) - [Tissue Diagnostics](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/tissue-diagnostics) - [Bacteriology Stains](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/tissue-diagnostics/bacteriology-stains) - [Cell Separation Media](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/tissue-diagnostics/cell-separation-media) - [Cytology Stains](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/tissue-diagnostics/cytology-stains) - [Dry Dyes & Certified Stains](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/tissue-diagnostics/dry-dyes-and-certified-stains) - [FISH Probes & Reagents](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/tissue-diagnostics/zytovision-in-situ-hybridization-probes) - [Hematology Stains](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/tissue-diagnostics/hematology-stains) - [Histology Stains](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/tissue-diagnostics/histology-stains) - [Tissue Diagnostics Universal Reagents](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/tissue-diagnostics/tissue-diagnostics-universal-reagents) - [Filtration](https://www.sigmaaldrich.com/US/en/products/filtration) - [Concentration Filters](https://www.sigmaaldrich.com/US/en/products/filtration/concentration-filters) - [Amicon<sup>®</sup> Centrifugals](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/amicon-centrifugals) - [Centrifugal Filters](https://www.sigmaaldrich.com/US/en/products/filtration/concentration-filters/centrifugal-filters) - [Filter Paper](https://www.sigmaaldrich.com/US/en/products/filtration/filter-paper) - [Filtration for Bioprocessing](https://www.sigmaaldrich.com/US/en/products/filtration/filtration-for-bioprocessing) - [Buffer Filtration](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/buffer-media-prep/buffer-filtration) - [Clarification Filter Holders & Systems](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/clarification-harvest/clarification-filter-holders-and-systems-for-bioprocessing) - [Filter Housings](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control/filter-housings) - [Final Sterile Filtration & Filling](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control/final-sterile-filtration-and-filling) - [Gas & Vent Filters](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control/gas-and-vent-filters) - [Integrity Testers](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control/integrity-testers) - [Media Filtration](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/buffer-media-prep/media-filtration) - [Prefilters & Bioburden Control](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control/prefilters-and-bioburden-control) - [Sterile Filters](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control/sterile-filters) - [Virus Filter Holders & Systems](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/viral-clearance/virus-filter-holders-and-systems) - [Virus Filters](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/viral-clearance/virus-filters) - [Laboratory Filter Holders](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-filter-holders) - [Laboratory Filter Membranes](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-filter-membranes) - [Filter Membranes](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-filter-membranes/filter-membranes) - [Millipore<sup>®</sup> Filter Membranes](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-filter-membranes/millipore-filter-membranes) - [Laboratory Syringe Filters](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-syringe-filters) - [Syringe Filters](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-syringe-filters/syringe-filters) - [Millex<sup>®</sup> Syringe Filters](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-syringe-filters/millex-syringe-filters) - [MultiScreen<sup>®</sup> Filter Plates](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/sterile-lab-media-filtration-and-cultureware/multiscreen-filter-plates) - [Sterile Laboratory Filter Devices](https://www.sigmaaldrich.com/US/en/products/filtration/sterile-laboratory-filter-devices) - [Millipore<sup>®</sup> Sterile Filters](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/sterile-lab-media-filtration-and-cultureware/millipore-sterile-filters) - [Stericup<sup>®</sup> Vacuum Filters](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/sterile-lab-media-filtration-and-cultureware/stericup-vacuum-filtration) - [Vacuum Filters](https://www.sigmaaldrich.com/US/en/products/filtration/vacuum-filters) - [Greener Alternative Products](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/greener-alternative-products) - [Industrial Microbiology](https://www.sigmaaldrich.com/US/en/products/industrial-microbiology) - [Environmental Monitoring & Aseptic Process Simulation](https://www.sigmaaldrich.com/US/en/products/industrial-microbiology/viable-air-samplers) - [Hygiene Monitoring](https://www.sigmaaldrich.com/US/en/products/industrial-microbiology/hygiene-monitoring-instruments-samplers-tests-and-accessories) - [Microbial Culture Media](https://www.sigmaaldrich.com/US/en/products/industrial-microbiology/microbial-culture-media) - [Microbial Culture Media Raw Materials](https://www.sigmaaldrich.com/US/en/products/industrial-microbiology/microbial-culture-media-raw-materials) - [Microbial Filtration](https://www.sigmaaldrich.com/US/en/products/industrial-microbiology/microbial-filtration) - [Microbial Identification Tests & Biochemical Reagents](https://www.sigmaaldrich.com/US/en/products/industrial-microbiology/microbial-identification-tests) - [Microbiology Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/microbiology-standards) - [Pathogen Screening Kits, Instruments, Disposables](https://www.sigmaaldrich.com/US/en/products/industrial-microbiology/pathogen-screening-kits-instuments-and-disposables) - [Pyrogen Testing](https://www.sigmaaldrich.com/US/en/products/industrial-microbiology/pyrogen-testing) - [Quality Indicator Testing Devices](https://www.sigmaaldrich.com/US/en/products/industrial-microbiology/quality-indicator-testing-devices) - [Sterility Testing Consumables, Media & Instruments](https://www.sigmaaldrich.com/US/en/products/industrial-microbiology/sterility-testing-consumables-media-and-filtration) - [Lab Automation](https://www.sigmaaldrich.com/US/en/products/lab-automation) - [AAW™ Automated Assay Workstation](https://www.sigmaaldrich.com/US/en/products/lab-automation/aaw-automated-assay-workstation) - [Labware](https://www.sigmaaldrich.com/US/en/products/labware) - [Cell Culture & Cryogenics](https://www.sigmaaldrich.com/US/en/products/labware/cell-culture-and-cryogenics) - [Cell Culture Supplies](https://www.sigmaaldrich.com/US/en/products/labware/cell-culture-and-cryogenics/cell-culture-supplies) - [Cryo Storage](https://www.sigmaaldrich.com/US/en/products/labware/cryo-storage) - [Millicell<sup>®</sup> Cell Culture Inserts & Plates](https://www.sigmaaldrich.com/US/en/products/labware/cell-culture-and-cryogenics/millicell-cell-culture-inserts-and-plates) - [Filtration](https://www.sigmaaldrich.com/US/en/products/labware/filtration) - [Centrifugal Filters](https://www.sigmaaldrich.com/US/en/products/filtration/concentration-filters/centrifugal-filters) - [Filter Membranes](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-filter-membranes/filter-membranes) - [Filter Paper](https://www.sigmaaldrich.com/US/en/products/filtration/filter-paper) - [Laboratory Filter Holders](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-filter-holders) - [Syringe Filters](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-syringe-filters/syringe-filters) - [Vacuum Filters](https://www.sigmaaldrich.com/US/en/products/filtration/vacuum-filters) - [Amicon<sup>®</sup> Centrifugals](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/amicon-centrifugals) - [Millex<sup>®</sup> Syringe Filters](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-syringe-filters/millex-syringe-filters) - [Millipore<sup>®</sup> Filter Membranes](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-filter-membranes/millipore-filter-membranes) - [Millipore<sup>®</sup> Sterile Filters](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/sterile-lab-media-filtration-and-cultureware/millipore-sterile-filters) - [MultiScreen<sup>®</sup> Filter Plates](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/sterile-lab-media-filtration-and-cultureware/multiscreen-filter-plates) - [Stericup<sup>®</sup> Vacuum Filters](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/sterile-lab-media-filtration-and-cultureware/stericup-vacuum-filtration) - [Glassware](https://www.sigmaaldrich.com/US/en/products/labware/glassware) - [Lab Equipment](https://www.sigmaaldrich.com/US/en/products/labware/laboratory-equipment) - [Balances](https://www.sigmaaldrich.com/US/en/products/labware/laboratory-equipment/laboratory-balances) - [Centrifugation](https://www.sigmaaldrich.com/US/en/products/labware/laboratory-equipment/laboratory-centrifugation) - [Grinders & Homogenizers](https://www.sigmaaldrich.com/US/en/products/labware/sample-handling/grinders-and-homogenizers) - [Laboratory Stirring & Mixing](https://www.sigmaaldrich.com/US/en/products/labware/sample-handling/laboratory-stirring-and-mixing) - [Refrigerators & Freezers](https://www.sigmaaldrich.com/US/en/products/labware/laboratory-equipment/refrigerators-freezers) - [Water Purification](https://www.sigmaaldrich.com/US/en/products/water-purification) - [Labware Partners](https://www.sigmaaldrich.com/US/en/products/labware/labware-partners) - [Benchmark Scientific Products](https://www.sigmaaldrich.com/US/en/products/labware/labware-partners/benchmark-scientific) - [Brand<sup>®</sup> Products](https://www.sigmaaldrich.com/US/en/products/labware/labware-partners/brand) - [Corning<sup>®</sup> Products](https://www.sigmaaldrich.com/US/en/products/labware/labware-partners/corning) - [Cytiva™ Products](https://www.sigmaaldrich.com/US/en/products/labware/labware-partners/cytiva) - [DWK Products](https://www.sigmaaldrich.com/US/en/products/labware/glassware/dwk) - [Eppendorf<sup>®</sup> Products](https://www.sigmaaldrich.com/US/en/products/labware/labware-partners/eppendorf) - [Excel Scientific Products](https://www.sigmaaldrich.com/US/en/products/labware/labware-partners/excel-scientific) - [Heathrow Scientific<sup>®</sup> Products](https://www.sigmaaldrich.com/US/en/products/labware/labware-partners/heathrow-scientific) - [LGC Biosearch™ Products](https://www.sigmaaldrich.com/US/en/products/labware/labware-partners/lgc-biosearch) - [OHAUS<sup>®</sup> Products](https://www.sigmaaldrich.com/US/en/products/labware/labware-partners/ohaus) - [Pop-Bio Products](https://www.sigmaaldrich.com/US/en/products/labware/labware-partners/pop-bio) - [Roche<sup>®</sup> Products](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/roche-life-science-products) - [Liquid Handling & Dispensing](https://www.sigmaaldrich.com/US/en/products/labware/liquid-handling-and-dispensing) - [Microscope Slides & Chambers](https://www.sigmaaldrich.com/US/en/products/labware/microscope-slides-and-chambers) - [PCR Supplies & Equipment](https://www.sigmaaldrich.com/US/en/products/labware/pcr-supplies-and-equipment) - [Plates](https://www.sigmaaldrich.com/US/en/products/labware/plates) - [Millicell<sup>®</sup> Cell Culture Inserts & Plates](https://www.sigmaaldrich.com/US/en/products/labware/cell-culture-and-cryogenics/millicell-cell-culture-inserts-and-plates) - [MultiScreen<sup>®</sup> Filter Plates](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/sterile-lab-media-filtration-and-cultureware/multiscreen-filter-plates) - [MultiScreen<sup>®</sup> Solid Bottom Plates](https://www.sigmaaldrich.com/US/en/products/labware/plates/multiscreen-solid-bottom-plates) - [Sample Handling](https://www.sigmaaldrich.com/US/en/products/labware/sample-handling) - [Grinders & Homogenizers](https://www.sigmaaldrich.com/US/en/products/labware/sample-handling/grinders-and-homogenizers) - [Laboratory Containers & Storage](https://www.sigmaaldrich.com/US/en/products/labware/sample-handling/laboratory-containers-and-storage) - [Laboratory Labels](https://www.sigmaaldrich.com/US/en/products/labware/sample-handling/laboratory-labels) - [Laboratory Sample Collection](https://www.sigmaaldrich.com/US/en/products/labware/sample-handling/laboratory-sample-collection) - [Laboratory Stirring & Mixing](https://www.sigmaaldrich.com/US/en/products/labware/sample-handling/laboratory-stirring-and-mixing) - [Sealing Films, Foils, Tapes](https://www.sigmaaldrich.com/US/en/products/labware/sealing-films-foils-and-tapes) - [Septa](https://www.sigmaaldrich.com/US/en/products/labware/septa) - [Materials Science](https://www.sigmaaldrich.com/US/en/products/materials-science) - [Biomedical Materials](https://www.sigmaaldrich.com/US/en/products/materials-science/biomedical-materials) - [3D Bioprinting](https://www.sigmaaldrich.com/US/en/products/materials-science/biomedical-materials/3d-bioprinting) - [Biomedical Polymers](https://www.sigmaaldrich.com/US/en/products/materials-science/biomedical-materials/biomedical-polymers) - [Drug Delivery Formulation Kits](https://www.sigmaaldrich.com/US/en/products/materials-science/biomedical-materials/drug-delivery-formulation-kits) - [Hydrophilic Polymers](https://www.sigmaaldrich.com/US/en/products/materials-science/biomedical-materials/hydrophilic-polymers) - [Hydrophobic Polymers](https://www.sigmaaldrich.com/US/en/products/materials-science/biomedical-materials/hydrophobic-polymers) - [Polyethylene Glycol (PEGs & PEOs)](https://www.sigmaaldrich.com/US/en/products/materials-science/biomedical-materials/polyethylene-glycol) - [Polymeric Microspheres & Nanoparticles](https://www.sigmaaldrich.com/US/en/products/materials-science/biomedical-materials/polymeric-microspheres-and-nanoparticles) - [Polymerization Tools](https://www.sigmaaldrich.com/US/en/products/materials-science/biomedical-materials/polymerization-tools) - [Electronic Materials](https://www.sigmaaldrich.com/US/en/products/materials-science/electronic-materials) - [Carbon Nanomaterials](https://www.sigmaaldrich.com/US/en/products/materials-science/electronic-materials/carbon-nanomaterials) - [Electronic Chemicals & Etchants](https://www.sigmaaldrich.com/US/en/products/materials-science/electronic-materials/electronic-chemicals-and-etchants) - [Inorganic & Metallic Nanomaterials](https://www.sigmaaldrich.com/US/en/products/materials-science/electronic-materials/inorganic-and-metallic-nanomaterials) - [Liquid Crystals](https://www.sigmaaldrich.com/US/en/products/materials-science/electronic-materials/liquid-crystals) - [OLED & PLED Materials](https://www.sigmaaldrich.com/US/en/products/materials-science/electronic-materials/oled-and-pled-materials) - [OFET & OPV Materials](https://www.sigmaaldrich.com/US/en/products/materials-science/electronic-materials/ofet-and-opv-materials) - [Photonic & Optical Materials](https://www.sigmaaldrich.com/US/en/products/materials-science/electronic-materials/photonic-and-optical-materials) - [Printed Electronic Materials](https://www.sigmaaldrich.com/US/en/products/materials-science/electronic-materials/printed-electronic-materials) - [Self-assembly & Contact Printing](https://www.sigmaaldrich.com/US/en/products/materials-science/electronic-materials/self-assembly-and-contact-printing) - [Silicone Materials](https://www.sigmaaldrich.com/US/en/products/materials-science/electronic-materials/silicone-materials) - [Specialty & Smart Polymers](https://www.sigmaaldrich.com/US/en/products/materials-science/electronic-materials/specialty-and-smart-polymers) - [Substrates & Prefab Electronic Components](https://www.sigmaaldrich.com/US/en/products/materials-science/electronic-materials/substrates-and-prefab-electronic-components) - [Energy Materials](https://www.sigmaaldrich.com/US/en/products/materials-science/energy-materials) - [Battery Materials](https://www.sigmaaldrich.com/US/en/products/materials-science/energy-materials/battery-materials) - [Chalcogenides](https://www.sigmaaldrich.com/US/en/products/materials-science/energy-materials/chalcogenides) - [Fuel Cell Membranes & Materials](https://www.sigmaaldrich.com/US/en/products/materials-science/energy-materials/fuel-cell-membranes-and-materials) - [High-Purity Metals & Alloys](https://www.sigmaaldrich.com/US/en/products/materials-science/energy-materials/high-purity-metals-and-alloys) - [High-Purity Salts](https://www.sigmaaldrich.com/US/en/products/materials-science/energy-materials/high-purity-salts) - [Oxides & Ceramics](https://www.sigmaaldrich.com/US/en/products/materials-science/energy-materials/oxides-and-ceramics) - [Quantum Dots](https://www.sigmaaldrich.com/US/en/products/materials-science/energy-materials/quantum-dots) - [Solar Energy Materials](https://www.sigmaaldrich.com/US/en/products/materials-science/energy-materials/solar-energy-materials) - [Solution & Vapor Deposition Precursors](https://www.sigmaaldrich.com/US/en/products/materials-science/energy-materials/solution-and-vapor-deposition-precursors) - [Molecular Biology & Functional Genomics](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics) - [Cloning & Expression](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/cloning-and-expression) - [Molecular Cloning & Protein Expression](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/cloning-and-expression/molecular-cloning-and-protein-expression) - [Transfection](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/cloning-and-expression/transfection) - [Epigenetics](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/epigenetics) - [Gene Editing & Functional Genomics](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/gene-editing-and-functional-genomics) - [CRISPR & Gene Editing](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/gene-editing-and-functional-genomics/crispr-gene-editing) - [Genetic Screening](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/gene-editing-and-functional-genomics/genetic-screening) - [RNAi Libraries](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/gene-editing-and-functional-genomics/rnai-libraries) - [RNAi Single Clones](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/gene-editing-and-functional-genomics/rnai-single-clones) - [<i>In situ</i> Hybridization Probes & Reagents](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/tissue-diagnostics/zytovision-in-situ-hybridization-probes) - [Microbiome](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/microbiome) - [NGS Library Preparation](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/ngs-library-prep) - [Nucleic Acid Electrophoresis & Hybridization](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/nucleic-acid-electrophoresis-and-hybridization) - [Nucleic Acid Electrophoresis, Transfer & Quantitation](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/nucleic-acid-electrophoresis-and-hybridization/nucleic-acid-electrophoresis-transfer-and-quantitation) - [Nucleic Acid Labeling](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/nucleic-acid-electrophoresis-and-hybridization/nucleic-acid-labeling) - [Nucleic Acid Purification](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/nucleic-acid-purification) - [gDNA Purification](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/nucleic-acid-purification/gdna-purification) - [Plasmid DNA Purification](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/nucleic-acid-purification/plasmid-dna-purification) - [Reaction Clean-Up](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/nucleic-acid-purification/reaction-clean-up) - [RNA Purification](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/nucleic-acid-purification/rna-purification) - [Oligos, qPCR Probes & Peptides](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/oligos-and-qpcr-probes) - [Custom & Predesigned DNA Oligos and qPCR Probes](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/oligos-and-qpcr-probes/custom-predesigned-dna-oligos-and-qpcr-probes) - [Custom & Predesigned RNA Oligos, siRNA Duplexes and Controls](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/oligos-and-qpcr-probes/custom-predesigned-rna-oligos-sirna-duplexes-controls) - [Custom Peptides](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/oligos-and-qpcr-probes/custom-peptides) - [PCR & Amplification](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/pcr-and-amplification) - [Kapa Biosystems PCR Reagents](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/pcr-and-amplification/kapa-biosystems-pcr-reagents) - [PCR Reagent & Kits](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/pcr-and-amplification/pcr-reagents-and-kits) - [PCR Supplies & Equipment](https://www.sigmaaldrich.com/US/en/products/labware/pcr-supplies-and-equipment) - [Whole Genome Amplification](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/pcr-and-amplification/whole-genome-amplification) - [Roche<sup>®</sup> Life Science Products](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/roche-life-science-products) - [mAbs Development & Manufacturing](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies) - [Antibody Drug Discovery](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/antibody-drug-discovery) - [Lead Selection & Optimization](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/antibody-drug-discovery/lead-discovery) - [Preclinical Development](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/antibody-drug-discovery/preclinical-development) - [Target Discovery](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/antibody-drug-discovery/target-discovery) - [Characterization & Quality Control](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/characterization-and-quality-control) - [Aggregate Analysis](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/characterization-and-quality-control/aggregate-analysis) - [Intact Mass Analysis](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/characterization-and-quality-control/intact-mass-analysis) - [Peptide Mapping](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/characterization-and-quality-control/peptide-mapping) - [Post-Translational Modification](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/characterization-and-quality-control/post-translational-modification-analysis) - [Titer Determination](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/characterization-and-quality-control/titer-determination) - [Process Development, Manufacturing, Formulation & Final Fill](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/process-development-manufacturing) - [Downstream Processing (DSP)](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/process-development-manufacturing/downstream-processing-mabs) - [Formulation & Final Fill](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/process-development-manufacturing/formulation-final-fill-mabs) - [Upstream Processing (USP)](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/process-development-manufacturing/upstream-processing-mabs) - [mRNA Development & Manufacturing](https://www.sigmaaldrich.com/US/en/integrated-offerings/mrna-development-manufacturing) - [mRNA Analytical & Quality Control](https://www.sigmaaldrich.com/US/en/integrated-offerings/mrna-development-manufacturing/mrna-analytical-quality-control) - [mRNA Development](https://www.sigmaaldrich.com/US/en/integrated-offerings/mrna-development-manufacturing/mrna-development) - [mRNA Manufacturing & Formulation](https://www.sigmaaldrich.com/US/en/integrated-offerings/mrna-development-manufacturing/mrna-manufacturing-formulation) - [mRNA Research](https://www.sigmaaldrich.com/US/en/integrated-offerings/mrna-development-manufacturing/mrna-research) - [Pharma & Biopharma Manufacturing](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing) - [Active Pharmaceutical Ingredients](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/active-pharmaceutical-ingredients) - [API Processing Chemicals](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/active-pharmaceutical-ingredients/api-processing-chemicals) - [Folates](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/active-pharmaceutical-ingredients/folates) - [Portfolio APIs](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/active-pharmaceutical-ingredients/portfolio-apis) - [Bioprocessing & Formulation Raw Materials](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-formulation-raw-materials) - [Bioprocessing Liquid Cell Culture Media & Buffers](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-formulation-raw-materials/liquid-cell-culture-media-buffers) - [Buffers & pH Adjusters](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/buffer-media-prep/buffers-and-ph-adjusters) - [Cleaning in Place](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-formulation-raw-materials/cleaning-in-place) - [Detergents for Biopharma Applications](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-formulation-raw-materials/detergents) - [Downstream Process & Formulation Chemicals](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-formulation-raw-materials/downstream-process-formulation-chemicals) - [Endonuclease](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-formulation-raw-materials/endonuclease) - [High-Quality Chemicals for mRNA Manufacturing](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-formulation-raw-materials/high-quality-chemicals-for-mrna-manufacturing) - [Upstream Process Chemicals](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-formulation-raw-materials/upstream-process-chemicals) - [Bioprocessing Cell Culture](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-cell-culture) - [Bioprocessing Cell Culture Media](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-cell-culture/bioprocessing-cell-culture-media) - [Bioprocessing Cell Lines](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-cell-culture/bioprocessing-cell-lines) - [Bioprocessing Liquid Cell Culture Media & Buffers](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-formulation-raw-materials/liquid-cell-culture-media-buffers) - [Bioprocessing Recombinant Supplements](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-cell-culture/recombinant-supplements) - [Bulk Powder Transfer Bags](https://www.sigmaaldrich.com/US/en/services/custom-products/bulk-powder-transfer-bags) - [Cell Retention](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-cell-culture/cell-retention) - [Custom GMP Cell Culture Media](https://www.sigmaaldrich.com/US/en/services/custom-products/custom-gmp-cell-culture-products) - [Media Filtration](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/buffer-media-prep/media-filtration) - [Viral Vector Upstream Platforms](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-cell-culture/viral-vector-upstream-platforms) - [Bioprocessing Systems](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-systems) - [Chromatography Columns for Bioprocessing](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/chromatography-bioprocessing/chromatography-columns) - [Chromatography Systems](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/chromatography-bioprocessing/chromatography-systems) - [Clarification Filter Holders & Systems](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/clarification-harvest/clarification-filter-holders-and-systems-for-bioprocessing) - [Integrity Testers](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control/integrity-testers) - [Single-Use Mixers](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/buffer-media-prep/single-use-mixers) - [Stainless Steel Connectors, Valves & Mixers](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/fluid-management/stainless-steel-connectors-valves-mixers) - [Tangential Flow Filtration Holders & Systems](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/ultrafiltration-diafiltration/tangential-flow-holders-systems) - [Virus Filter Holders & Systems](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/viral-clearance/virus-filter-holders-and-systems) - [Buffer & Media Prep](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/buffer-media-prep) - [Buffers & pH Adjusters](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/buffer-media-prep/buffers-and-ph-adjusters) - [Buffer Filtration](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/buffer-media-prep/buffer-filtration) - [Media Filtration](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/buffer-media-prep/media-filtration) - [Single-Use Mixers](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/buffer-media-prep/single-use-mixers) - [Chromatography](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/chromatography-bioprocessing) - [Affinity Chromatography Resins](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/chromatography-bioprocessing/affinity-resins) - [Chromatography Columns for Bioprocessing](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/chromatography-bioprocessing/chromatography-columns) - [Chromatography Systems](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/chromatography-bioprocessing/chromatography-systems) - [Ion Exchange Chromatography Resins](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/chromatography-bioprocessing/ion-exchange-chromatography) - [Membrane Chromatography](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/chromatography-bioprocessing/membrane-chromatography) - [Reverse Phase/Normal Phase Chromatography Resins](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/chromatography-bioprocessing/reverse-normal-phase-chromatography) - [Size Exclusion Chromatography Resins](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/chromatography-bioprocessing/size-exclusion-chromatography) - [Clarification & Harvest](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/clarification-harvest) - [Clarification Depth Filters & Pretreatment Solutions](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/clarification-harvest/clarification-depth-filters-pretreatment-solutions) - [Clarification Filter Holders & Systems](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/clarification-harvest/clarification-filter-holders-and-systems-for-bioprocessing) - [Clarification Prefilters](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/clarification-harvest/clarification-prefilters) - [Fluid Management](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/fluid-management) - [Connection/Disconnection for Bioprocessing](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/fluid-management/connection-disconnection-for-bioprocessing) - [Fluid Transport & Storage](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/fluid-management/fluid-transport-and-storage) - [Single-Use Assemblies](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/fluid-management/single-use-assemblies) - [Single-Use Mixers](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/buffer-media-prep/single-use-mixers) - [Stainless Steel Connectors, Valves & Mixers](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/fluid-management/stainless-steel-connectors-valves-mixers) - [Formulation](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation) - [Activated & Functionalized PEGs](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/activated-functionalized-pegs) - [Biomolecule Formulation](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/biomolecule-formulation) - [Granulated Materials](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/granulated-materials) - [Injectables & Parenteral Formulations](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/injectables-parenteral-formulations) - [Liquid Formulation](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/liquid-formulation) - [Protein Stabilizers](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/protein-stabilizers) - [Semisolid Formulation](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/semisolid-formulation) - [Solid Formulation](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/solid-formulation) - [Synthetic Lipids](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/synthetic-lipids) - [Viscosity Reduction Platform](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/viscosity-reduction-platform) - [Sterile & Aseptic Sampling Solutions](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-and-aseptic-sampling) - [Sterile Process Sampling](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-and-aseptic-sampling/manual-sterile-sampling) - [Sampling with MAST<sup>®</sup> Autosampling Solution](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-and-aseptic-sampling/automated-aseptic-sampling) - [Sterile Filtration & Bioburden Control](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control) - [Buffer Filtration](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/buffer-media-prep/buffer-filtration) - [Filter Housings](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control/filter-housings) - [Final Sterile Filtration & Filling](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control/final-sterile-filtration-and-filling) - [Gas & Vent Filters](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control/gas-and-vent-filters) - [Integrity Testers](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control/integrity-testers) - [Media Filtration](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/buffer-media-prep/media-filtration) - [Prefilters & Bioburden Control](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control/prefilters-and-bioburden-control) - [Sterile Filters](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control/sterile-filters) - [Ultrafiltration & Diafiltration](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/ultrafiltration-diafiltration) - [Tangential Flow Filtration Devices](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/ultrafiltration-diafiltration/filtration-devices) - [Tangential Flow Filtration Holders & Systems](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/ultrafiltration-diafiltration/tangential-flow-holders-systems) - [Viral Clearance](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/viral-clearance) - [Integrity Testers](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control/integrity-testers) - [Virus Filter Holders & Systems](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/viral-clearance/virus-filter-holders-and-systems) - [Virus Filters](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/viral-clearance/virus-filters) - [Virus Inactivation](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/viral-clearance/virus-inactivation) - [Protein Biology](https://www.sigmaaldrich.com/US/en/products/protein-biology) - [Antibodies](https://www.sigmaaldrich.com/US/en/products/protein-biology/antibodies) - [Enhanced Validation Antibodies](https://www.sigmaaldrich.com/US/en/products/protein-biology/antibodies/enhanced-validation-ab) - [Flow Cytometry Antibodies](https://www.sigmaaldrich.com/US/en/products/protein-biology/antibodies/flow-cytometry-antibodies) - [Prestige Antibodies<sup>®</sup>](https://www.sigmaaldrich.com/US/en/products/protein-biology/antibodies/prestige-antibodies) - [Primary Antibodies](https://www.sigmaaldrich.com/US/en/products/protein-biology/antibodies/primary-antibodies) - [Secondary Antibodies](https://www.sigmaaldrich.com/US/en/products/protein-biology/antibodies/secondary-antibodies) - [Small Pack Antibodies](https://www.sigmaaldrich.com/US/en/products/protein-biology/antibodies/small-pack-antibodies) - [ZooMAb<sup>®</sup> Recombinant Antibodies](https://www.sigmaaldrich.com/US/en/products/protein-biology/antibodies/zoomab-antibodies) - [Bioactive Small Molecules](https://www.sigmaaldrich.com/US/en/products/protein-biology/bioactive-small-molecules) - [Structural Genomics Consortium](https://www.sigmaaldrich.com/US/en/products/protein-biology/bioactive-small-molecules/structural-genomics-consortium) - [Duolink<sup>®</sup> PLA - Protein Interaction Technology](https://www.sigmaaldrich.com/US/en/products/protein-biology/duolink-proximity-ligation-assay) - [Immunoassay Platform Solutions](https://www.sigmaaldrich.com/US/en/products/protein-biology/immunoassay-platform-solutions) - [ELISA Kits](https://www.sigmaaldrich.com/US/en/products/protein-biology/immunoassay-platform-solutions/elisa-kits) - [MILLIPLEX<sup>®</sup> Kits](https://www.sigmaaldrich.com/US/en/products/protein-biology/immunoassay-platform-solutions/milliplex-multiplex-assays-for-luminex-technology) - [SMC<sup>™</sup> Technology](https://www.sigmaaldrich.com/US/en/products/protein-biology/immunoassay-platform-solutions/single-molecule-counting-technology) - [Protein Electrophoresis & Western Blotting](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-electrophoresis-and-western-blotting) - [Electrophoresis & Transfer Equipment](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-electrophoresis-and-western-blotting/electrophoresis-and-transfer-equipment) - [Transfer Membranes & Kits](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-electrophoresis-and-western-blotting/transfer-membranes-and-kits) - [Immunodetection Reagents & Substrates](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-electrophoresis-and-western-blotting/immunodetection-reagents-and-substrates) - [Membrane Immunodetection Devices](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-electrophoresis-and-western-blotting/membrane-immunodetection-devices) - [Protein Electrophoresis Gels & Buffers](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-electrophoresis-and-western-blotting/protein-electrophoresis-gels-and-buffers) - [Protein Electrophoresis Gel Stains](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-electrophoresis-and-western-blotting/protein-electrophoresis-gel-stains) - [Protein Markers](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-electrophoresis-and-western-blotting/protein-markers) - [Transfer Buffers & Reagents](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-electrophoresis-and-western-blotting/transfer-buffers-and-reagents) - [Proteins & Enzymes](https://www.sigmaaldrich.com/US/en/products/protein-biology/proteins-and-enzymes) - [Albumins & Transport Proteins](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents/albumins-and-transport-proteins) - [Coenzymes](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/coenzymes) - [Detection Substrates & Enzymes](https://www.sigmaaldrich.com/US/en/products/protein-biology/proteins-and-enzymes/detection-substrates-and-enzymes) - [Drug Analysis Enzymes](https://www.sigmaaldrich.com/US/en/products/protein-biology/proteins-and-enzymes/drug-analysis-enzymes) - [Glycobiology Profiling Tools](https://www.sigmaaldrich.com/US/en/products/protein-biology/proteins-and-enzymes/glycosidases) - [Nucleases](https://www.sigmaaldrich.com/US/en/products/protein-biology/proteins-and-enzymes/nucleases) - [Proteases](https://www.sigmaaldrich.com/US/en/products/protein-biology/proteins-and-enzymes/proteases) - [Tissue Dissociation](https://www.sigmaaldrich.com/US/en/products/protein-biology/proteins-and-enzymes/tissue-dissociation) - [Protein Mass Spectrometry](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-mass-spectrometry) - [Protein Purification Chromatography](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-purification-chromatography) - [Antibody Protein Purification](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/antibody-protein-purification) - [Biotinylated Protein Purification](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/biotinylated-protein-purification) - [FLAG<sup>®</sup> Purification](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/flag-purification) - [Recombinant/Fusion Tag Protein Purification](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/recombinant-fusion-tag-protein-purification) - [Protein Sample Prep](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep) - [Amicon<sup>®</sup> Centrifugals](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/amicon-centrifugals) - [Antibody Protein Purification](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/antibody-protein-purification) - [Biotinylated Protein Purification](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/biotinylated-protein-purification) - [FLAG<sup>®</sup> Purification](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/flag-purification) - [Inhibitor Cocktails](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/inhibitor-cocktails) - [Laboratory Concentration Devices](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/laboratory-concentration-devices) - [Laboratory Dialysis & Diafiltration Devices](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/laboratory-dialysis-and-diafiltration-devices) - [Recombinant/Fusion Tag Protein Purification](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/recombinant-fusion-tag-protein-purification) - [Subcellular Fractionation Reagents](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/subcellular-fractionation-reagents) - [Whole Cell Lysis Reagents & Enhancers](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/whole-cell-lysis-reagents-and-enhancers) - [Water Purification](https://www.sigmaaldrich.com/US/en/products/water-purification) - [Milli-Q<sup>®</sup> Benchtop Water Purification Systems](https://www.sigmaaldrich.com/US/en/products/water-purification/milli-q-benchtop-water-purification-systems) - [Milli-Q<sup>®</sup> High-Flow Water Purification Systems](https://www.sigmaaldrich.com/US/en/products/water-purification/milli-q-high-flow-water-purification-systems) - [Milli-Q<sup>®</sup> Clinical Water Purification Systems](https://www.sigmaaldrich.com/US/en/products/water-purification/milli-q-clinical-water-purification-systems) - [Milli-Q<sup>®</sup> Consumables](https://www.sigmaaldrich.com/US/en/products/water-purification/milli-q-consumables) - [Milli-Q<sup>®</sup> Accessories](https://www.sigmaaldrich.com/US/en/products/water-purification/milli-q-accessories) - Applications - [Analytical Chemistry](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry) - [Atomic Spectroscopy](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/atomic-spectroscopy) - [Calibration, Qualification, Validation](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/calibration-qualification-and-validation) - [Gas Chromatography (GC)](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/gas-chromatography) - [Liquid Chromatography](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/liquid-chromatography) - [Large Molecule HPLC](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/liquid-chromatography/large-molecule-hplc) - [Low Pressure Liquid Chromatography](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/liquid-chromatography/low-pressure-liquid-chromatography) - [Small Molecule HPLC](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/liquid-chromatography/small-molecule-hplc) - [Mass Spectrometry (MS)](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/mass-spectrometry) - [Nuclear Magnetic Resonance (NMR)](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/nuclear-magnetic-resonance) - [Photometry & Reflectometry](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/photometry-and-reflectometry) - [Sample Preparation](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/sample-preparation) - [Sample Filtration](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/sample-preparation/filtration) - [Sample Purification](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/sample-preparation/purification) - [QuEChERS Sample Preparation](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/sample-preparation/quechers) - [Solid Phase Extraction](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/sample-preparation/solid-phase-extraction) - [Solid Phase Microextraction](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/sample-preparation/solid-phase-microextraction) - [Thin Layer Chromatography (TLC)](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/thin-layer-chromatography) - [Titration & Karl Fischer](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/titration-and-karl-fischer) - [Water for Analytical Chemistry](https://www.sigmaaldrich.com/US/en/applications/water-purification/water-analytical-chemistry) - [Wet Chemical Analysis](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/wet-chemical-analysis) - [Cell Culture & Analysis](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis) - [Cell Analysis](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-analysis) - [Cell-based Assays](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-analysis/cell-based-assays) - [Cell Counting & Health analysis](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-analysis/cell-counting-and-health-analysis) - [Imaging Analysis & Live Cell Imaging](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-analysis/imaging-analysis-and-live-cell-imaging) - [Cell Culture by Cell Type](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-culture-by-cell-type) - [Mammalian Cell Culture](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-culture-by-cell-type/mammalian-cell-culture) - [Microbial Cell Culture](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-culture-by-cell-type/microbial-cell-culture) - [Plant Tissue Culture](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-culture-by-cell-type/plant-tissue-culture) - [Primary Cell Culture](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-culture-by-cell-type/primary-cell-culture) - [Stem Cell Culture](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-culture-by-cell-type/stem-cell-culture) - [Cell Culture by Technique](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-culture-by-technique) - [3D Cell Culture](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-culture-by-technique/3d-cell-culture) - [Cell Culture Media Preparation](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-culture-by-technique/cell-culture-media-preparation) - [Cell Growth & Maintenance](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-culture-by-technique/cell-growth-and-maintenance) - [Transfection & Gene Editing](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-culture-by-technique/transfection-and-gene-editing) - [Cell Culture for Manufacturing](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-culture-for-manufacturing) - [Cell Culture Troubleshooting](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-culture-troubleshooting) - [Chemistry & Synthesis](https://www.sigmaaldrich.com/US/en/applications/chemistry-and-synthesis) - [ADC & Bioconjugation](https://www.sigmaaldrich.com/US/en/applications/chemistry-and-synthesis/adc-and-bioconjugation) - [Lead Discovery](https://www.sigmaaldrich.com/US/en/applications/chemistry-and-synthesis/lead-discovery) - [Peptide Synthesis](https://www.sigmaaldrich.com/US/en/applications/chemistry-and-synthesis/peptide-synthesis) - [Protein Degradation](https://www.sigmaaldrich.com/US/en/applications/chemistry-and-synthesis/protein-degradation) - [Reaction Design & Optimization](https://www.sigmaaldrich.com/US/en/applications/chemistry-and-synthesis/reaction-design-and-optimization) - [Synthetic Methods](https://www.sigmaaldrich.com/US/en/applications/chemistry-and-synthesis/synthetic-methods) - [C-H Functionalization](https://www.sigmaaldrich.com/US/en/applications/chemistry-and-synthesis/synthetic-methods/ch-functionalization) - [Cross Coupling](https://www.sigmaaldrich.com/US/en/applications/chemistry-and-synthesis/synthetic-methods/cross-coupling) - [Fluorination](https://www.sigmaaldrich.com/US/en/applications/chemistry-and-synthesis/synthetic-methods/fluorination) - [Metathesis](https://www.sigmaaldrich.com/US/en/applications/chemistry-and-synthesis/synthetic-methods/metathesis) - [Organic Reaction Toolbox](https://www.sigmaaldrich.com/US/en/applications/chemistry-and-synthesis/synthetic-methods/organic-reaction-toolbox) - [Photocatalysis](https://www.sigmaaldrich.com/US/en/applications/chemistry-and-synthesis/synthetic-methods/photocatalysis) - [Clinical & Diagnostics](https://www.sigmaaldrich.com/US/en/applications/clinical-testing-and-diagnostics-manufacturing) - [Bacteriology](https://www.sigmaaldrich.com/US/en/applications/clinical-testing-and-diagnostics-manufacturing/bacteriology) - [Blood Typing](https://www.sigmaaldrich.com/US/en/applications/clinical-testing-and-diagnostics-manufacturing/blood-typing) - [Clinical & Forensics Testing](https://www.sigmaaldrich.com/US/en/applications/clinical-testing-and-diagnostics-manufacturing/clinical-and-forensic-testing) - [Cytology & Cytodiagnosis](https://www.sigmaaldrich.com/US/en/applications/clinical-testing-and-diagnostics-manufacturing/cytology-and-microscopy) - [Diagnostic Immunohistochemistry](https://www.sigmaaldrich.com/US/en/applications/clinical-testing-and-diagnostics-manufacturing/diagnostic-immunohistochemistry) - [Hematology](https://www.sigmaaldrich.com/US/en/applications/clinical-testing-and-diagnostics-manufacturing/hematology) - [Histology/Histopathology](https://www.sigmaaldrich.com/US/en/applications/clinical-testing-and-diagnostics-manufacturing/histology) - [IVD Manufacturing](https://www.sigmaaldrich.com/US/en/applications/clinical-testing-and-diagnostics-manufacturing/ivd-manufacturing) - [Water for Clinical Diagnostics](https://www.sigmaaldrich.com/US/en/applications/water-purification/water-clinical-diagnostics) - [Environmental & Cannabis Testing](https://www.sigmaaldrich.com/US/en/applications/environmental-testing-and-industrial-hygiene) - [Air Sampling & Monitoring](https://www.sigmaaldrich.com/US/en/applications/environmental-testing-and-industrial-hygiene/air-testing) - [Cannabis Testing](https://www.sigmaaldrich.com/US/en/applications/environmental-testing-and-industrial-hygiene/cannabis-testing) - [Cannabinoids & Potency](https://www.sigmaaldrich.com/US/en/applications/environmental-testing-and-industrial-hygiene/cannabis-testing/cannabinoid-profiling-potency-testing) - [Pesticides & Mycotoxins](https://www.sigmaaldrich.com/US/en/applications/environmental-testing-and-industrial-hygiene/cannabis-testing/pesticides-mycotoxins-in-cannabis) - [Terpenes](https://www.sigmaaldrich.com/US/en/applications/environmental-testing-and-industrial-hygiene/cannabis-testing/terpenes-cannabis) - [Drinking Water Testing​](https://www.sigmaaldrich.com/US/en/applications/environmental-testing-and-industrial-hygiene/drinking-water-testing) - [Soil, Solid Waste, & Groundwater Testing](https://www.sigmaaldrich.com/US/en/applications/environmental-testing-and-industrial-hygiene/soil-solid-waste-groundwater-testing) - [Waste Water & Process Water Testing](https://www.sigmaaldrich.com/US/en/applications/environmental-testing-and-industrial-hygiene/waste-water-and-process-water-testing) - [Food & Beverage Testing & Manufacturing](https://www.sigmaaldrich.com/US/en/applications/food-and-beverage-testing-and-manufacturing) - [Chemical Analysis](https://www.sigmaaldrich.com/US/en/applications/food-and-beverage-testing-and-manufacturing/chemical-analysis-for-food-and-beverage) - [Flavor & Fragrance Formulation](https://www.sigmaaldrich.com/US/en/applications/food-and-beverage-testing-and-manufacturing/flavor-and-fragrance-formulation) - [Microbiological Analysis](https://www.sigmaaldrich.com/US/en/applications/food-and-beverage-testing-and-manufacturing/microbiological-analysis-for-food-and-beverage) - [Regulatory Compliance​](https://www.sigmaaldrich.com/US/en/applications/food-and-beverage-testing-and-manufacturing/regulatory-compliance-for-food-and-beverage) - [Genomics](https://www.sigmaaldrich.com/US/en/applications/genomics) - [Advanced Gene Editing](https://www.sigmaaldrich.com/US/en/applications/genomics/advanced-gene-editing) - [Cloning & Expression](https://www.sigmaaldrich.com/US/en/applications/genomics/cloning-and-expression) - [DNA & RNA Purification](https://www.sigmaaldrich.com/US/en/applications/genomics/dna-and-rna-purification) - [Epigenetics](https://www.sigmaaldrich.com/US/en/applications/genomics/epigenetics) - [Functional Genomics Screening](https://www.sigmaaldrich.com/US/en/applications/genomics/functional-genomics-screening) - [Gene Expression & Silencing](https://www.sigmaaldrich.com/US/en/applications/genomics/gene-expression-and-silencing) - [Next Gen Sequencing](https://www.sigmaaldrich.com/US/en/applications/genomics/next-gen-sequencing) - [Nucleic Acid Gel Electrophoresis](https://www.sigmaaldrich.com/US/en/applications/genomics/nucleic-acid-gel-electrophoresis) - [Nucleic Acid Labeling & Detection](https://www.sigmaaldrich.com/US/en/applications/genomics/nucleic-acid-labeling-and-detection) - [PCR](https://www.sigmaaldrich.com/US/en/applications/genomics/pcr) - [qPCR](https://www.sigmaaldrich.com/US/en/applications/genomics/qpcr) - [Sequencing](https://www.sigmaaldrich.com/US/en/applications/genomics/sequencing) - [Materials Science & Engineering](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering) - [3D Bioprinting](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/3d-bioprinting) - [3D Printing](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/3d-printing) - [Batteries, Supercapacitors, Fuel Cells](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/batteries-supercapacitors-and-fuel-cells) - [Bioelectronics](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/bioelectronics) - [Biosensors & Bioimaging](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/biosensors-and-bioimaging) - [Chemical Vapor Deposition](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/chemical-vapor-deposition) - [Contact Lens & Dental Manufacturing](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/contact-lens-and-dental-manufacturing) - [Drug Delivery](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/drug-delivery) - [Electron Microscopy](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/electron-microscopy) - [Microelectronics & Nanoelectronics](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/microelectronics-and-nanoelectronics) - [Nanoparticle & Microparticle Synthesis](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/nanoparticle-and-microparticle-synthesis) - [Organic Electronics](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/organic-electronics) - [Photovoltaics & Solar Cells](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/photovoltaics-and-solar-cells) - [Polymer Synthesis](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/polymer-synthesis) - [Solid State Synthesis](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/solid-state-synthesis) - [Tissue Engineering](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/tissue-engineering) - [Microbiological Testing](https://www.sigmaaldrich.com/US/en/applications/microbiological-testing) - [Bioburden Testing](https://www.sigmaaldrich.com/US/en/applications/microbiological-testing/bioburden-testing) - [Culture Media Preparation](https://www.sigmaaldrich.com/US/en/applications/microbiological-testing/microbial-culture-media-preparation) - [Media Fill (APS)](https://www.sigmaaldrich.com/US/en/applications/microbiological-testing/media-fills) - [Microbial Water Testing](https://www.sigmaaldrich.com/US/en/applications/microbiological-testing/microbial-water-testing) - [Mycoplasma Testing](https://www.sigmaaldrich.com/US/en/applications/microbiological-testing/mycoplasma-testing) - [Pathogen & Spoilage Testing](https://www.sigmaaldrich.com/US/en/applications/microbiological-testing/pathogen-and-spoilage-testing) - [Pyrogen Testing](https://www.sigmaaldrich.com/US/en/applications/microbiological-testing/pyrogen-testing) - [Sterility Testing](https://www.sigmaaldrich.com/US/en/applications/microbiological-testing/sterility-testing) - [Surface & Personnel Testing](https://www.sigmaaldrich.com/US/en/applications/microbiological-testing/surface-and-personnel-testing) - [Viable Air Monitoring](https://www.sigmaaldrich.com/US/en/applications/microbiological-testing/viable-air-monitoring) - [mAbs Development & Manufacturing](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies) - [Antibody Drug Discovery](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/antibody-drug-discovery) - [Lead Selection & Optimization](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/antibody-drug-discovery/lead-discovery) - [Preclinical Development](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/antibody-drug-discovery/preclinical-development) - [Target Discovery](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/antibody-drug-discovery/target-discovery) - [Characterization & Quality Control](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/characterization-and-quality-control) - [Aggregate Analysis](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/characterization-and-quality-control/aggregate-analysis) - [Intact Mass Analysis](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/characterization-and-quality-control/intact-mass-analysis) - [Peptide Mapping](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/characterization-and-quality-control/peptide-mapping) - [Post-Translational Modification](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/characterization-and-quality-control/post-translational-modification-analysis) - [Titer Determination](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/characterization-and-quality-control/titer-determination) - [Process Development, Manufacturing, Formulation & Final Fill](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/process-development-manufacturing) - [Downstream Processing (DSP)](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/process-development-manufacturing/downstream-processing-mabs) - [Formulation & Final Fill](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/process-development-manufacturing/formulation-final-fill-mabs) - [Upstream Processing (USP)](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/process-development-manufacturing/upstream-processing-mabs) - [mRNA Development & Manufacturing](https://www.sigmaaldrich.com/US/en/integrated-offerings/mrna-development-manufacturing) - [mRNA Analytical & Quality Control](https://www.sigmaaldrich.com/US/en/integrated-offerings/mrna-development-manufacturing/mrna-analytical-quality-control) - [mRNA Development](https://www.sigmaaldrich.com/US/en/integrated-offerings/mrna-development-manufacturing/mrna-development) - [mRNA Manufacturing & Formulation](https://www.sigmaaldrich.com/US/en/integrated-offerings/mrna-development-manufacturing/mrna-manufacturing-formulation) - [mRNA Research](https://www.sigmaaldrich.com/US/en/integrated-offerings/mrna-development-manufacturing/mrna-research) - [Pharma & Biopharma Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing) - [Antibody Drug Conjugate Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/adc-manufacturing) - [Conjugation](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/adc-manufacturing/conjugation) - [Purification](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/adc-manufacturing/antibody-drug-conjugate-manufacturing-purification) - [Biopharma 4.0](https://www.sigmaaldrich.com/US/en/integrated-offerings/biopharma-4-0) - [Bioprocessing Automation & Control Software](https://www.sigmaaldrich.com/US/en/integrated-offerings/biopharma-4-0/bioprocessing-automation-control-software) - [Bioprocessing Data Analytics Software](https://www.sigmaaldrich.com/US/en/integrated-offerings/biopharma-4-0/bioprocessing-data-analytics-software) - [Closed Processing for Biomanufacturing](https://www.sigmaaldrich.com/US/en/integrated-offerings/biopharma-4-0/closed-processing-for-biomanufacturing) - [Intensified & Continuous Upstream (USP) Processing](https://www.sigmaaldrich.com/US/en/integrated-offerings/biopharma-4-0/intensified-upstream-processing) - [Intensified & Continuous Downstream (DSP) Processing](https://www.sigmaaldrich.com/US/en/integrated-offerings/biopharma-4-0/intensified-continuous-downstream-processing) - [Process Analytical Technology (PAT)](https://www.sigmaaldrich.com/US/en/integrated-offerings/biopharma-4-0/process-analytical-technology) - [Biotech Resource Hub](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/biotech-resource-hub) - [Discovery](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/biotech-resource-hub/discovery) - [Pre-clinical](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/biotech-resource-hub/pre-clinical) - [Phase I-II](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/biotech-resource-hub/phase-i-ii) - [Phase III and Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/biotech-resource-hub/phase-iii-and-manufacturing) - [Regulatory](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/biotech-resource-hub/regulatory) - [Startup Programs](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/biotech-resource-hub/startup-programs) - [Blood Plasma Fractionation](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/plasma-manufacturing) - [Cell Therapy Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/cell-therapy-manufacturing) - [Classical Pharma Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/classical-pharma-manufacturing) - [Final Fill Strategies](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/classical-pharma-manufacturing/final-fill-strategies) - [Liquid Formulation Strategies](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/classical-pharma-manufacturing/liquid-formulation-strategies) - [Solid Formulation Strategies](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/classical-pharma-manufacturing/solid-formulation-strategies) - [Sterile Filtration Strategies](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/classical-pharma-manufacturing/sterile-filtration-strategies) - [Gene Therapy Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/gene-therapy-manufacturing) - [Viral Vector Upstream Processing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/gene-therapy-manufacturing/viral-vector-upstream-processing) - [Viral Vector Downstream Processing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/gene-therapy-manufacturing/viral-vector-downstream-processing) - [Viral Vector Formulation & Final Fill](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/gene-therapy-manufacturing/viral-vector-formulation-and-final-fill) - [Viral Vector Characterization & Biosafety Testing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/gene-therapy-manufacturing/viral-vector-characterization-and-biosafety-testing) - [Viral Vector Contract Development & Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/gene-therapy-manufacturing/viral-vector-contract-development-and-manufacturing) - [Pharma Analysis & QC](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/pharmaceutical-analysis-quality-control) - [Biologics & Biosimilars Characterization](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/pharmaceutical-analysis-quality-control/biologics-biosimilars-characterization) - [Compendial Testing & Regulatory Guidance](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/pharmaceutical-analysis-quality-control/compendial-testing-regulatory-guidance) - [Small Molecules Analysis & Quality Control (QC)](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/pharmaceutical-analysis-quality-control/small-molecules-analysis-quality-control) - [Sterile & Aseptic Sampling](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/sampling) - [Vaccine Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/vaccine-manufacturing) - [Cell-Based Vaccine Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/vaccine-manufacturing/cell-based-vaccine-manufacturing) - [mRNA Vaccine Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/vaccine-manufacturing/mrna-vaccines-process-manufacturing) - [pDNA Vaccine Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/vaccine-manufacturing/plasmid-dna-vaccines-manufacturing) - [Protein Subunit Vaccine Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/vaccine-manufacturing/protein-subunit-vaccine-manufacturing) - [Viral-like Particles Vaccine Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/vaccine-manufacturing/viral-like-particles-vaccine-manufacturing) - [Viral Vector Vaccine Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/vaccine-manufacturing/viral-vector-vaccine-manufacturing) - [Protein Biology](https://www.sigmaaldrich.com/US/en/applications/protein-biology) - [ELISA](https://www.sigmaaldrich.com/US/en/applications/protein-biology/elisa) - [Enzyme Activity Assays](https://www.sigmaaldrich.com/US/en/applications/protein-biology/enzyme-activity-assays) - [Flow Cytometry](https://www.sigmaaldrich.com/US/en/applications/protein-biology/flow-cytometry) - [Gel Electrophoresis](https://www.sigmaaldrich.com/US/en/applications/protein-biology/gel-electrophoresis) - [Immunohistochemistry](https://www.sigmaaldrich.com/US/en/applications/protein-biology/immunohistochemistry) - [Interrogation of Protein Pathways](https://www.sigmaaldrich.com/US/en/applications/protein-biology/interrogation-protein-pathways) - [Lysis & Protein Extraction](https://www.sigmaaldrich.com/US/en/applications/protein-biology/lysis-and-protein-extraction) - [Protein & Nucleic Acid Interactions](https://www.sigmaaldrich.com/US/en/applications/protein-biology/protein-and-nucleic-acid-interactions) - [Protein Concentration & Buffer Exchange](https://www.sigmaaldrich.com/US/en/applications/protein-biology/protein-concentration-and-buffer-exchange) - [Protein Expression](https://www.sigmaaldrich.com/US/en/applications/protein-biology/protein-expression) - [Protein Labeling & Modification](https://www.sigmaaldrich.com/US/en/applications/protein-biology/protein-labeling-and-modification) - [Protein Pulldown](https://www.sigmaaldrich.com/US/en/applications/protein-biology/protein-pulldown) - [Protein Purification](https://www.sigmaaldrich.com/US/en/applications/protein-biology/protein-purification) - [Protein Quantitation](https://www.sigmaaldrich.com/US/en/applications/protein-biology/protein-quantitation) - [Protein Structural Analysis](https://www.sigmaaldrich.com/US/en/applications/protein-biology/protein-structural-analysis) - [Western Blotting](https://www.sigmaaldrich.com/US/en/applications/protein-biology/western-blotting) - [Protein Mass Spectrometry](https://www.sigmaaldrich.com/US/en/applications/protein-biology/protein-mass-spectrometry) - [Research & Disease Areas](https://www.sigmaaldrich.com/US/en/applications/research-disease-areas) - [Cancer Research](https://www.sigmaaldrich.com/US/en/applications/research-disease-areas/cancer-research) - [Cell & Developmental Biology Research](https://www.sigmaaldrich.com/US/en/applications/research-disease-areas/cell-and-developmental-biology-research) - [Cell Signaling](https://www.sigmaaldrich.com/US/en/applications/research-disease-areas/cell-signaling) - [Glycobiology](https://www.sigmaaldrich.com/US/en/applications/research-disease-areas/glycobiology) - [Metabolomics Research](https://www.sigmaaldrich.com/US/en/applications/research-disease-areas/metabolomics-research) - [Neuroscience Research](https://www.sigmaaldrich.com/US/en/applications/research-disease-areas/neuroscience-research) - [Pharmacology & Drug Discovery Research](https://www.sigmaaldrich.com/US/en/applications/research-disease-areas/pharmacology-and-drug-discovery-research) - [Water Purification](https://www.sigmaaldrich.com/US/en/applications/water-purification) - [Water for Analytical Chemistry](https://www.sigmaaldrich.com/US/en/applications/water-purification/water-analytical-chemistry) - [Water for Cell & Molecular Biology](https://www.sigmaaldrich.com/US/en/applications/water-purification/water-cell-molecular-biology) - [Water for Clinical Diagnostics](https://www.sigmaaldrich.com/US/en/applications/water-purification/water-clinical-diagnostics) - [Understanding Lab Water](https://www.sigmaaldrich.com/US/en/applications/water-purification/understanding-lab-water) - Services - [Contract Manufacturing](https://www.sigmaaldrich.com/US/en/services/contract-manufacturing) - [ADC & Bioconjugation](https://www.sigmaaldrich.com/US/en/services/contract-manufacturing/adc-bioconjugation) - [Diagnostic OEM & CMO Services](https://www.sigmaaldrich.com/US/en/services/ivd-development-manufacturing/diagnostic-oem-cmo) - [mRNA & LNP](https://www.sigmaaldrich.com/US/en/services/contract-manufacturing/mrna-and-lnp-formulation-ctdmo-services) - [Lipids CDMO Services](https://www.sigmaaldrich.com/US/en/services/contract-manufacturing/mrna-and-lnp-formulation-ctdmo-services/lipids-cdmo-services) - [Lipid Nanoparticle CDMO Service](https://www.sigmaaldrich.com/US/en/services/contract-manufacturing/mrna-and-lnp-formulation-ctdmo-services/lipid-nanoparticle-cdmo-services) - [Small Molecule](https://www.sigmaaldrich.com/US/en/services/contract-manufacturing/small-molecule) - [Activated Polyethylene Glycol (PEGs)](https://www.sigmaaldrich.com/US/en/services/contract-manufacturing/peg) - [APIs](https://www.sigmaaldrich.com/US/en/services/contract-manufacturing/complex-apis) - [Highly Potent APIs](https://www.sigmaaldrich.com/US/en/services/contract-manufacturing/high-potent-apis) - [Viral Vector](https://www.sigmaaldrich.com/US/en/services/contract-manufacturing/viral-vector-manufacturing) - [AAV Production](https://www.sigmaaldrich.com/US/en/services/contract-manufacturing/viral-vector-manufacturing/aav-production) - [Gene Therapy Process Development](https://www.sigmaaldrich.com/US/en/services/contract-manufacturing/viral-vector-manufacturing/gene-therapy-process-development) - [Lentiviral Vectors](https://www.sigmaaldrich.com/US/en/services/contract-manufacturing/viral-vector-manufacturing/lentiviral-vectors) - [Contract Testing](https://www.sigmaaldrich.com/US/en/services/contract-testing) - [Analytical Development](https://www.sigmaaldrich.com/US/en/services/contract-testing/analytical-development-product-characterization) - [ADC Product Characterization](https://www.sigmaaldrich.com/US/en/services/contract-testing/analytical-development-product-characterization/adc-characterization) - [Analytical Development and Characterization for Adeno-Associated Virus (AAV)](https://www.sigmaaldrich.com/US/en/services/contract-testing/analytical-development-product-characterization/analytical-development-characterization-adeno-associated-virus) - [mAb Product Characterization](https://www.sigmaaldrich.com/US/en/services/contract-testing/analytical-development-product-characterization/mab-characterization) - [mRNA Analytical Development](https://www.sigmaaldrich.com/US/en/services/contract-testing/analytical-development-product-characterization/mrna-analytical-development) - [Bulk Harvest Release Testing](https://www.sigmaaldrich.com/US/en/services/contract-testing/bulk-harvest-release-testing) - [Cell & Gene Therapy Bulk Harvest Release Testing](https://www.sigmaaldrich.com/US/en/services/contract-testing/bulk-harvest-release-testing/cell-gene-therapy) - [mAbs Bulk Harvest Release Testing](https://www.sigmaaldrich.com/US/en/services/contract-testing/bulk-harvest-release-testing/mabs-bulk) - [Vaccine Harvest Release Testing](https://www.sigmaaldrich.com/US/en/services/contract-testing/bulk-harvest-release-testing/vaccine) - [Cell & Virus Bank Manufacturing & Testing](https://www.sigmaaldrich.com/US/en/services/contract-testing/cell-viral-bank-testing) - [Biorepository & Storage](https://www.sigmaaldrich.com/US/en/services/contract-testing/cell-viral-bank-testing/storage) - [Cell Bank Manufacturing](https://www.sigmaaldrich.com/US/en/services/contract-testing/cell-viral-bank-testing/cell-bank-manufacturing) - [Cell Line Characterization](https://www.sigmaaldrich.com/US/en/services/contract-testing/cell-viral-bank-testing/cell-line-characterization) - [Genetic Stability Testing](https://www.sigmaaldrich.com/US/en/services/contract-testing/cell-viral-bank-testing/genetic-stability-testing) - [Virus Bank Manufacturing](https://www.sigmaaldrich.com/US/en/services/contract-testing/cell-viral-bank-testing/virus-bank-manufacturing) - [Final Product Release Testing](https://www.sigmaaldrich.com/US/en/services/contract-testing/final-product-release-testing) - [Cell & Gene Therapy Final Product Release Testing](https://www.sigmaaldrich.com/US/en/services/contract-testing/final-product-release-testing/cell-gene-therapy) - [mAbs Final Product Release Testing](https://www.sigmaaldrich.com/US/en/services/contract-testing/final-product-release-testing/mabs-product-release-testing) - [Rapid Molecular Detection](https://www.sigmaaldrich.com/US/en/services/contract-testing/rapid-molecular-detection) - [Blazar™ Rapid Molecular Detection](https://www.sigmaaldrich.com/US/en/services/contract-testing/rapid-molecular-detection/blazar-rapid-molecular-detection) - [Next Generation Sequencing](https://www.sigmaaldrich.com/US/en/services/contract-testing/rapid-molecular-detection/next-generation-sequencing) - [Raw Material Testing](https://www.sigmaaldrich.com/US/en/services/contract-testing/raw-material-testing) - [Stability Testing Services](https://www.sigmaaldrich.com/US/en/services/contract-testing/stability-testing-services) - [Viral Clearance Testing](https://www.sigmaaldrich.com/US/en/services/contract-testing/viral-clearance-testing) - [Provise<sup>®</sup> Clearance Services](https://www.sigmaaldrich.com/US/en/services/contract-testing/viral-clearance-testing/complete-clearance) - [Standard & Hybrid Clearance Services](https://www.sigmaaldrich.com/US/en/services/contract-testing/viral-clearance-testing/standard-clearance) - [Custom Products](https://www.sigmaaldrich.com/US/en/services/custom-products) - [Bulk Powder Transfer Bags](https://www.sigmaaldrich.com/US/en/services/custom-products/bulk-powder-transfer-bags) - [CADI: Custom Assay Development & Innovation](https://www.sigmaaldrich.com/US/en/services/custom-products/custom-milliplex-multiplex-assays-and-elisas) - [Cell Culture Media Stability & Testing Services](https://www.sigmaaldrich.com/US/en/services/custom-products/cell-culture-media-stability-and-testing-services) - [Cell Design Studio™ Cell Engineering Services](https://www.sigmaaldrich.com/US/en/services/custom-products/custom-cell-lines) - [CHOZN<sup>®</sup> Cell Line Engineering and Development](https://www.sigmaaldrich.com/US/en/services/custom-products/chozn-cell-line-engineering-and-development) - [Contract ZooMAb<sup>®</sup> Antibody Development Services](https://www.sigmaaldrich.com/US/en/services/custom-products/contract-zoomab-antibody-development-services) - [Critical Raw Materials](https://www.sigmaaldrich.com/US/en/services/custom-products/critical-raw-materials) - [Custom Diagnostic Antibody Development & Manufacturing Services](https://www.sigmaaldrich.com/US/en/services/ivd-development-manufacturing/custom-diagnostic-antibody-development-and-manufacturing-services) - [Custom GC Columns](https://www.sigmaaldrich.com/US/en/services/custom-products/customized-gc-columns) - [Custom GMP Cell Culture Media](https://www.sigmaaldrich.com/US/en/services/custom-products/custom-gmp-cell-culture-products) - [Custom HPLC Columns](https://www.sigmaaldrich.com/US/en/services/custom-products/custom-hplc-column-request) - [Custom Media Development Services](https://www.sigmaaldrich.com/US/en/services/custom-products/custom-media-development-services) - [Custom Nucleic Acids](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/oligos-and-qpcr-probes) - [Custom SPE Tubes & 96-Well Plates](https://www.sigmaaldrich.com/US/en/services/custom-products/custom-spe-tubes-and-96-well-plates) - [Custom SPME Fibers](https://www.sigmaaldrich.com/US/en/services/custom-products/custom-spme-fibers) - [Custom Test Strips & Papers](https://www.sigmaaldrich.com/US/en/services/custom-products/custom-test-strips-and-papers) - [Diagnostic OEM & CMO Services](https://www.sigmaaldrich.com/US/en/services/ivd-development-manufacturing/diagnostic-oem-cmo) - [Eshmuno<sup>®</sup> Fit Custom Affinity Resin Development Services](https://www.sigmaaldrich.com/US/en/services/custom-products/eshmuno-fit-custom-affinity-resin-development-services) - [Production-Scale Materials & Custom Services](https://www.sigmaaldrich.com/US/en/services/custom-products/bulk-and-custom-services) - [Large-Volume Products Supply-Chain](https://www.sigmaaldrich.com/US/en/services/custom-products/bulk-and-custom-services/large-volume-products-supply-chain) - [Scalable Manufacturing & Custom Packaging](https://www.sigmaaldrich.com/US/en/services/custom-products/bulk-and-custom-services/scalable-manufacturing-and-custom-packaging) - [Reference Materials](https://www.sigmaaldrich.com/US/en/services/custom-products/reference-materials) - [Small Molecule Library Design (Aldrich Market Select)](https://www.sigmaaldrich.com/US/en/services/custom-products/small-molecule-library-design) - [Stable Isotope Custom & GMP Products](https://www.sigmaaldrich.com/US/en/services/custom-products/stable-isotope-custom-and-gmp-products) - [Digital Solutions for Life Science](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms) - [AIDDISON™ AI-Powered Drug Discovery Software](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/aiddison-ai-powered-drug-discovery) - [Belysa<sup>®</sup> Immunoassay Curve Fitting Software](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/belysa-immunoassay-curve-fitting-software) - [Bioprocessing Automation and Control Software](https://www.sigmaaldrich.com/US/en/integrated-offerings/biopharma-4-0/bioprocessing-automation-control-software) - [Bioprocessing Data Analytics Software](https://www.sigmaaldrich.com/US/en/integrated-offerings/biopharma-4-0/bioprocessing-data-analytics-software) - [Catalexis Catalysts Screening Platform](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/catalexis-catalyst-screening-platform) - [Chemistwin<sup>®</sup> Digital Reference Materials](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/digital-reference-materials) - [DEL Extended Digital Service](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/dna-encoded-library-technology-drug-discovery) - [DOZN™ Tool](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/dozn-tool) - [mConfig™ Cell Culture Media and Chemicals Configurator](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/mconfig-cell-culture-media-chemicals-configurator) - [M-Trace<sup>®</sup> Electronic Test Record Software](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/m-trace-electronic-test-record-software) - [Millicell<sup>®</sup> Cloud Services](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/millicell-cloud-services) - [MQuant<sup>®</sup> StripScan](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/mquant-stripscan) - [MyMilli-Q<sup>™</sup> Digital Services](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/mymilli-q-digital-services) - [SYNTHIA<sup>™</sup> Retrosynthesis Software](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/synthia-retrosynthesis-software) - [Val@M™ Application for Validation Activites](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/valatm-validation-platform) - [IVD Development & Manufacturing](https://www.sigmaaldrich.com/US/en/services/ivd-development-manufacturing) - [Custom Diagnostic Antibody Development & Manufacturing Services](https://www.sigmaaldrich.com/US/en/services/ivd-development-manufacturing/custom-diagnostic-antibody-development-and-manufacturing-services) - [Diagnostic OEM & CMO Services](https://www.sigmaaldrich.com/US/en/services/ivd-development-manufacturing/diagnostic-oem-cmo) - [Lateral Flow Assay Development Services](https://www.sigmaaldrich.com/US/en/services/ivd-development-manufacturing/lateral-flow-services) - [Product Services](https://www.sigmaaldrich.com/US/en/services/product-services) - [Application Services for Solid Dose Formulations](https://www.sigmaaldrich.com/US/en/services/product-services/application-services-solid-dose-formulations) - [Calibration & Verification](https://www.sigmaaldrich.com/US/en/services/product-services/calibration-and-verification) - [Milli-Q<sup>®</sup> Calibration & Verification](https://www.sigmaaldrich.com/US/en/services/product-services/calibration-and-verification/calibration-verification-suitability-testing-of-milli-q-water-pu) - [Microbiology Testing Systems](https://www.sigmaaldrich.com/US/en/services/product-services/calibration-and-verification/calibration-verification-microbiology) - [Elevate Program](https://www.sigmaaldrich.com/US/en/services/product-services/elevate-quality-program) - [eMERGE™ Program](https://www.sigmaaldrich.com/US/en/services/product-services/the-emerge-standard-edata-exchange-platform) - [Emprove<sup>®</sup> Program](https://www.sigmaaldrich.com/US/en/services/product-services/emprove-program) - [Emprove<sup>®</sup> Cell Culture Media](https://www.sigmaaldrich.com/US/en/services/product-services/emprove-program/emprove-cell-culture-media) - [Emprove<sup>®</sup> Chemicals Portfolio](https://www.sigmaaldrich.com/US/en/services/product-services/emprove-program/emprove-chemicals-portfolio) - [Emprove<sup>®</sup> Chromatography Portfolio](https://www.sigmaaldrich.com/US/en/services/product-services/emprove-program/emprove-chromatography-portfolio) - [Emprove<sup>®</sup> Filter and Single-Use Component Portfolio](https://www.sigmaaldrich.com/US/en/services/product-services/emprove-program/emprove-filter-and-single-use-component-portfolio) - [Emprove<sup>®</sup> Suite](https://www.sigmaaldrich.com/US/en/services/product-services/emprove-program/emprove-suite) - [Maintenance & Service Plans](https://www.sigmaaldrich.com/US/en/services/product-services/maintenance-and-service-plans) - [Microbiology Testing Systems](https://www.sigmaaldrich.com/US/en/services/product-services/maintenance-and-service-plans/microbiology-maintenance-and-service-plans) - [Milli-Q<sup>®</sup> Maintenance & Service Plans](https://www.sigmaaldrich.com/US/en/services/product-services/maintenance-and-service-plans/milli-q-services-plans-and-maintenance-for-water-purification-sy) - [Spectroquant<sup>®</sup> Photometer Services](https://www.sigmaaldrich.com/US/en/services/product-services/maintenance-and-service-plans/spectroquant-photometer-services) - [System Service Reliance Plans](https://www.sigmaaldrich.com/US/en/services/product-services/maintenance-and-service-plans/system-service-reliance-plans) - [Milli-Q<sup>®</sup> Services & Support](https://www.sigmaaldrich.com/US/en/services/product-services/milli-q-services-and-support) - [Maintenance & Service Plans](https://www.sigmaaldrich.com/US/en/services/product-services/maintenance-and-service-plans/milli-q-services-plans-and-maintenance-for-water-purification-sy) - [Qualification & Validation](https://www.sigmaaldrich.com/US/en/services/product-services/systems-qualification/milliq-qualification-program) - [Calibration & Verification](https://www.sigmaaldrich.com/US/en/services/product-services/calibration-and-verification/calibration-verification-suitability-testing-of-milli-q-water-pu) - [Additional Services](https://www.sigmaaldrich.com/US/en/services/product-services/milli-q-services-and-support/milli-q-additional-services) - [MyMilli-Q™ Digital Services](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/mymilli-q-digital-services) - [mPredict™ Co-Crystal Prediction Service](https://www.sigmaaldrich.com/US/en/services/product-services/m-predict-co-crystal-prediction-service) - [Single-Use & Filter Validation Services](https://www.sigmaaldrich.com/US/en/services/product-services/single-use-filter-validation) - [Bacterial Retention​ Testing](https://www.sigmaaldrich.com/US/en/services/product-services/single-use-filter-validation/bacterial-retention) - [Chemical Compatibility​ Testing](https://www.sigmaaldrich.com/US/en/services/product-services/single-use-filter-validation/chemical-compatibility) - [Extractables & Leachables​](https://www.sigmaaldrich.com/US/en/services/product-services/single-use-filter-validation/extractables-and-leachables) - [Filter Integrity Testing​](https://www.sigmaaldrich.com/US/en/services/product-services/single-use-filter-validation/integrity-testing) - [Validation Service Levels](https://www.sigmaaldrich.com/US/en/services/product-services/single-use-filter-validation/validation-service-levels) - [Validation Services Consultancy​](https://www.sigmaaldrich.com/US/en/services/product-services/single-use-filter-validation/validation-services-consultancy) - [Systems & Equipment Installation](https://www.sigmaaldrich.com/US/en/services/product-services/systems-and-equipment-installation) - [Bioprocessing Systems Equipment Installation](https://www.sigmaaldrich.com/US/en/services/product-services/systems-and-equipment-installation/bioprocessing-systems-equipment) - [Bioprocessing System Training & Specialized Services](https://www.sigmaaldrich.com/US/en/services/product-services/systems-and-equipment-installation/bioprocessing-systems-training) - [Microbiology Testing Systems](https://www.sigmaaldrich.com/US/en/services/product-services/systems-and-equipment-installation/system-and-equipment-installation-microbiology-testing-systems) - [Systems Qualification](https://www.sigmaaldrich.com/US/en/services/product-services/systems-qualification) - [Bioprocessing Systems Qualification](https://www.sigmaaldrich.com/US/en/services/product-services/systems-qualification/bioprocessing-systems-qualification) - [Food & Beverages QC Systems Qualification](https://www.sigmaaldrich.com/US/en/services/product-services/systems-qualification/food-and-beverage-qc-systems-qualification) - [Milli-Q<sup>®</sup> Qualification & Validation](https://www.sigmaaldrich.com/US/en/services/product-services/systems-qualification/milliq-qualification-program) - [Pharma QC Systems Qualification](https://www.sigmaaldrich.com/US/en/services/product-services/systems-qualification/pharma-qc-systems-qualification) - [Validation Services](https://www.sigmaaldrich.com/US/en/services/product-services/validation-services) - [Food & Beverage Microbiology Method Validation](https://www.sigmaaldrich.com/US/en/services/product-services/validation-services/food-and-beverage-microbiology-method-validation) - [Pharma Microbiology Method Development & Validation](https://www.sigmaaldrich.com/US/en/services/product-services/validation-services/pharma-microbiology-method-development-validation) - [Val@M™ Application for Validation Activites](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/valatm-validation-platform) - [Support](https://www.sigmaaldrich.com/US/en/services/support) - [Inventory Management](https://www.sigmaaldrich.com/US/en/services/support/inventory-management) - [M Lab™ Collaboration Centers](https://www.sigmaaldrich.com/US/en/services/support/mlab-collaboration-centers) - [Programs](https://www.sigmaaldrich.com/US/en/life-science/partnership-programs) - [Recycling](https://www.sigmaaldrich.com/US/en/services/support/recycling) - [Biopharma Recycling Program](https://www.sigmaaldrich.com/US/en/services/support/recycling/biopharma-recycling-program) - [Greener Cooler](https://www.sigmaaldrich.com/US/en/services/support/recycling/greener-cooler) - [Polystyrene Cooler Recycling](https://www.sigmaaldrich.com/US/en/services/support/recycling/polystyrene-cooler-return-program) - [Training & Education](https://www.sigmaaldrich.com/US/en/services/support/training-and-education) - Resources - [Documents](https://www.sigmaaldrich.com/US/en/documents-search?tab=coa) - [Certificates of Analysis (COA)](https://www.sigmaaldrich.com/US/en/documents-search?tab=coa) - [Safety Data Sheets (SDS)](https://www.sigmaaldrich.com/US/en/documents-search?tab=sds) - [Certificates of Quality (COQ)](https://www.sigmaaldrich.com/US/en/documents-search?tab=coq) - [Certificates of Origin (COO)](https://www.sigmaaldrich.com/US/en/documents-search?tab=coo) - [Learning Center](https://www.sigmaaldrich.com/US/en/life-science/learning-center) - Support - [Customer Support](https://www.sigmaaldrich.com/US/en/support/customer-support) - [Contact Us](https://www.sigmaaldrich.com/US/en/collections/offices) - [Get Site Smart](https://www.sigmaaldrich.com/US/en/life-science/ecommerce/website-update-info) - [FAQ](https://maestro.my.site.com/knowledgeportal/s/) - [Quality & Regulatory](https://www.sigmaaldrich.com/US/en/life-science/quality-and-regulatory-management) - [Calculators & Apps](https://www.sigmaaldrich.com/US/en/support/calculators-and-apps) - [Webinars](https://www.sigmaaldrich.com/US/en/collections/webinars)