This product is not tested for solubility. However, various literature sources note that the material is soluble at 1 mg/mL in water. Higher concentrations have been achieved with pH adjustment. Please see the link below to review a publication that may be helpful:
https://pmc.ncbi.nlm.nih.gov/articles/PMC11440154/
SMB00607
Amoxicillin trihydrate: potassium clavulanate (4:1)
Synonym(s):
Amoxicillin Trihydrate: Potassium Clavulanate
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| Size/SKU | Availability | Price |
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1 g | Check Cart for Availability | $239.00 |
About This Item
NACRES:
NA.85
UNSPSC Code:
51285005
form
powder
Quality Segment
storage condition
(Keep container tightly closed in a dry and well-ventilated place. Never allow produc to get in contact with water during storage.)
color
white to yellow
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
cell wall synthesis | interferes
storage temp.
2-8°C
General description
Amoxicillin trihydrate is a semisynthetic antibiotic, that is used as a medicine.
Application
Amoxicillin trihydrate: potassium clavulanate (4:1) has been used to study its effect on the viral déjà vu disease (neonatal intracerebral (i.c.) infection) in mice model.
Biochem/physiol Actions
Amoxicillin trihydrate is a broad-spectrum, β-lactam antibiotic. It inhibits the cross-linkage between linear peptidoglycan polymer chains that are the major component of both Gram-positive and Gram-negative bacteria.[1][2] Since amoxicillin is degraded by β-lactamases, it does not show activity against bacteria which produce these enzymes.
Clavulanate is a β-lactam antibiotic related to the penicillins. Clavulanate competitively and irreversibly inhibits a wide variety of β-lactamases[3] found in bacteria that are resistant to penicillins and cephalosporins.[4]
Formulations of amoxicillin with clavulanic acid prevent the degradation of amoxicillin by β-lactamase enzymes. This increases amoxicillin′s antibacterial activity against bacteria normally resistant to β-lactam antibiotics.[5]
Clavulanate is a β-lactam antibiotic related to the penicillins. Clavulanate competitively and irreversibly inhibits a wide variety of β-lactamases[3] found in bacteria that are resistant to penicillins and cephalosporins.[4]
Formulations of amoxicillin with clavulanic acid prevent the degradation of amoxicillin by β-lactamase enzymes. This increases amoxicillin′s antibacterial activity against bacteria normally resistant to β-lactam antibiotics.[5]
Packaging
1G
Preparation Note
Keep container tightly closed in a dry and well-ventilated place. Never allow produc to get in contact with water during storage.
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Never allow product to get in contact with water during storage.
Material is a powdered mixture of 4 parts amoxicillin trihydrate to 1 part potassium clavulanate.
1 of 1
This Item | |||
|---|---|---|---|
| description - | description 900-1050 μg/mg anhydrous basis (HPLC) | description VETRANAL®, analytical standard | description VETRANAL®, analytical standard |
| mode of action cell wall synthesis | interferes | mode of action cell wall synthesis | interferes | mode of action - | mode of action cell wall synthesis | interferes |
| antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria | antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria | antibiotic activity spectrum - | antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria |
| Quality Level 200 | Quality Level 200 | Quality Level 100 | Quality Level 100 |
| form powder | form powder or crystals | form - | form - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| color white to yellow | color - | color - | color white to off-white |
signalword
Danger
hcodes
Hazard Classifications
Flam. Sol. 2 - Resp. Sens. 1 - Self-heat. 2 - Skin Sens. 1
supp_hazards
Storage Class
4.2 - Pyrophoric and self-heating hazardous materials
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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What is the solubility of Amoxicillin trihydrate: potassium clavulanate (4:1) (SMB00607)?
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What are the uses and potential reactions of Amoxicillin and Clavulanate Potassium
1 answer-
This product is supplied for research purposes with the primary use as an antibiotic. Formulations of amoxicillin with clavulanic acid prevent the degradation of amoxicillin by β-lactamase enzymes. This increases amoxicillin's antibacterial activity against bacteria normally resistant to β-lactam antibiotics. Please see the peer-reviewed paper section in the link below for potential use information.
Products are not tested for safety and efficacy in food, drug, medical device, cosmetic, commercial, or any other use. Potential reactions or side effects are not evaluated.
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