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344282

Forskolin

from Coleus forskohlii, ≥97% (HPLC), liquid, positive inotropic agent, Calbiochem

Synonym(s):

Forskolin, Coleus forskohlii in DMSO

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Size/SKUAvailabilityPrice
5 mg
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$122.00

About This Item

Empirical Formula (Hill Notation):
C22H34O7
Molecular Weight:
410.50
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥97% (HPLC)
Form:
liquid
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light

$122.00

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Product Name

Forskolin, Coleus forskohlii in DMSO, The major cell-permeable diterpene isolated from the Indian plant Coleus forskohlii.

Quality Segment

100

assay

≥97% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

shipped in

wet ice

storage temp.

−20°C

General description

The major cell-permeable diterpene isolated from the Indian plant Coleus forskohlii.
The major cell-permeable diterpene isolated from the Indian plant Coleus forskohlii. At low doses, it acts as a positive inotropic agent. At higher doses, it serves as a hypotensive and vasodilatory agent due to its actions as a smooth muscle relaxant. No major side effects are observed at effective doses. Forskolins pharmacological activities are due to its activation of adenylate cyclase (EC50 = 4 µM), resulting in increased cAMP levels. The exact mechanism of forskolins positive inotropic effect is unknown but may be related to a cAMP-dependent increase in Na+ permeability that results in indirect augmentation of Ca2+ release. Inhibits MAP kinase in rat renal mesangial cells (IC50 = 25 µM). Also acts as a Hh pathway antagonist. Shown to inhibit apoptosis in cerebellar granule cells and to induce apoptosis in resting human B lymphocytes. The solid form of this compound (Cat. No. 344270) is also available.

Packaging

Packaged under inert gas

Physical form

A 50 mM (5 mg/244 µl) solution of Forskolin, Coleus forskohlii (Cat. No. 344270) in DMSO.

Preparation Note

Following initial thaw, aliquot and freeze (-20°C).

Other Notes

D′Orazio, J.A., et al. 2006. Nature443, 340.
Noveen, A., et al. 1996. Biochem. Biophys. Res. Commun.219, 180.
Galli, C., et al. 1995. J. Neurosci.15, 1172.
Li, X., et al. 1995. Am. J. Physiol.269, C986.
Lomo, J., et al. 1995. J. Immunol.154, 1634.
Uneyama, H., et al. 1993. J. Biol. Chem.268, 168.
Laurenza, A., et al. 1989. Trends Pharmacol. Sci.10, 442.
Adashi, E.Y., and Resnick, C.E. 1986. J. Cell. Biochem.31, 217.
Seamon, K.B., and Daly, J.W. 1986. Adv. Cyclic Nucleotide Protein Phosphorylation Res.20, 1.
Huang, R., et al. 1982. Cyclic Nucleotide Res.8, 385.
Metzger, H., and Lindner, E. 1981. IRCS Med. Sci. Biochem. Cardiovasc. System Pharmacol.9, 99.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

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Forskolin, Coleus forskohlii in DMSO The major cell-permeable diterpene isolated from the Indian plant Coleus forskohlii.

Sigma-Aldrich

344282

Forskolin, Coleus forskohlii in DMSO

Forskolin from Coleus forskohlii, ≥98% (HPLC), powder

Sigma-Aldrich

F6886

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Sigma-Aldrich

208925

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Sigma-Aldrich

580555

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description

The major cell-permeable diterpene isolated from the Indian plant Coleus forskohlii.

description

from Coleus forskohlii, ≥98% (HPLC), powder

description

A cell-permeable DNA topoisomerase I inhibitor.

description

Antitumor and antileukemic agent isolated from the bark of the yew tree.

assay

≥97% (HPLC)

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPLC)

form

liquid

form

powder

form

solid

form

solid

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

−20°C

storage temp.

-

storage temp.

2-8°C

storage temp.

−20°C

storage condition

protect from light, desiccated (hygroscopic), OK to freeze

storage condition

-

storage condition

OK to freeze

storage condition

protect from light, OK to freeze, desiccated

Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

188.6 °F - (refers to pure substance)

flash_point_c

87 °C - (refers to pure substance)

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