The molecular weight of this material is lot specific and may range from 500,000. - 1,200,000 Da. The exact molecular weight of this product is reported in the Certificate of Analysis . Please navigate to the ‘DOCUMENTATION’ section of the Product Detail Page to access a Certificate under ‘Certificate of Analysis’:
https://www.sigmaaldrich.com/product/mm/385908#product-dcuemntation
385908
Hyaluronic Acid, Sodium Salt, Streptococcus pyrogenes
Natural high-viscosity mucopolysaccharide with alternating β1,3-glucuronidic and β1,4-glucosaminidic bonds. Principal glycosaminoglycan in connective tissue fluids.
Synonym(s):
Hyaluronic Acid, Sodium Salt, Streptococcus pyrogenes
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| Size/SKU | Availability | Price |
|---|---|---|
500 mg | Check Cart for Availability | $395.00 |
About This Item
Form:
lyophilized
Storage condition:
OK to freeze, desiccated (hygroscopic)
description
Merck USA index - 14, 4757
Quality Segment
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
impurities
≤0.070 EU/mg endotoxins (EU/mg NaHy), ≤0.1% protein
solubility
water: 10 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
[Na+].N([C@H]1[C@@H](O[C@@H]([C@H]([C@@H]1O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)C(=O)O)O)CO)O[C@@H]2[C@H](O[C@H]([C@@H]([C@H]2O)O)O[C@@H]3[C@H]([C@@H](O[C@@H]([C@H]3O)CO)O)NC(=O)C)C(=O)O)C(=O)C
InChI
1S/C28H44N2O23.Na/c1-5(33)29-9-18(11(35)7(3-31)47-25(9)46)49-28-17(41)15(39)20(22(53-28)24(44)45)51-26-10(30-6(2)34)19(12(36)8(4-32)48-26)50-27-16(40)13(37)14(38)21(52-27)23(42)43;/h7-22,25-28,31-32,35-41,46H,3-4H2,1-2H3,(H,29,33)(H,30,34)(H,42,43)(H,44,45);/q;+1/t7-,8-,9-,10-,11-,12-,13+,14+,15-,16-,17-,18-,19-,20+,21+,22+,25-,26+,27-,28-;/m1./s1
InChI key
YWIVKILSMZOHHF-QJZPQSOGSA-N
General description
Natural high-viscosity mucopolysaccharide with alternating β1,3-glucuronidic and β1,4-glucosaminidic bonds. Principal glycosaminoglycan in connective tissue fluids. The molecular weight of Hyaluronic Acid, Sodium Salt, is in the range of 5.0 x 105 - 1.2 x 106, as calculated from its limiting viscosity.
Application
- Hyaluronic Acid as a LYVE-1 Receptor Ligand in the Lymphatic System of Healthy Human Skin.: This study investigates the role of hyaluronic acid as a ligand for the LYVE-1 receptor in the lymphatic system, offering insights into its physiological roles and potential therapeutic applications, particularly in treating lymphatic-related diseases (Michurina et al., 2024).
- M2 Macrophage-Derived Extracellular Vesicles Encapsulated in Hyaluronic Acid Alleviate Osteoarthritis by Modulating Macrophage Polarization.: This research explores the therapeutic potential of M2 macrophage-derived extracellular vesicles encapsulated in hyaluronic acid for osteoarthritis treatment. It highlights a novel anti-inflammatory mechanism that could be significant for biochemists studying cellular therapies (Yuan et al., 2024).
- Insights into Translational and Biomedical Applications of Hydrogels as Versatile Drug Delivery Systems.: This review covers the use of hyaluronic acid in hydrogel drug delivery systems, emphasizing its utility in various biomedical applications. It provides a detailed analysis of the material′s properties, applications, and future potential in drug delivery and tissue engineering (Kohar et al., 2024).
- Utilizing Ni(II) complex for metal drug-gel particles in cervical cancer treatment and designing novel drugs through machine learning methods.: Although primarily focused on Ni(II) complex, this study discusses the integration of metal drug-gel particles with hyaluronic acid, offering insights into its potential as a carrier for targeted therapy in cervical cancer (Jiang et al., 2024).
Preparation Note
Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 3 months at 4°C in the absence of contamination.
Heating slowly to 50°C may be required for complete solubilization.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
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This Item | |||
|---|---|---|---|
| description Natural high-viscosity mucopolysaccharide with alternating β1,3-glucuronidic and β1,4-glucosaminidic bonds. Principal glycosaminoglycan in connective tissue fluids. | description mol wt 750,000-1,000,000 | description mol wt 150,000-300,000 | description mol wt 130,000-150,000 |
| form lyophilized | form powder | form powder | form powder |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| manufacturer/tradename Calbiochem® | manufacturer/tradename - | manufacturer/tradename - | manufacturer/tradename - |
| storage temp. 2-8°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| storage condition OK to freeze, desiccated (hygroscopic) | storage condition - | storage condition - | storage condition - |
| solubility water: 10 mg/mL | solubility water: ~5 g/L | solubility - | solubility water: ~5 g/L |
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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