The minimum potency of this product is ≥6.0 IU/mg. This information is lot-specific and reported in the Certificate of Analysis. Please see the link below to access a lot-specific Certificate:
https://www.sigmaaldrich.com/product/mm/869006m#product-documentation
869006-M
Thyroid Stimulating Hormone, Human Pituitary, Iodination Grade
Synonym(s):
Thyroid Stimulating Hormone, Human Pituitary, Iodination Grade, Thyrotropin, hTSH
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| Size/SKU | Availability | Price |
|---|---|---|
10 μg | Check Cart for Availability | $275.00 |
50 μg | Check Cart for Availability | $755.00 |
100 μg | Check Cart for Availability | $1,350.00 |
About This Item
Biological source:
human pituitary glands
Form:
lyophilized solid
Assay:
≥95% (weight)
biological source
human pituitary glands
Quality Segment
description
Merck USA index - 14, 9414
sterility
non-sterile
assay
≥95% (weight)
form
lyophilized solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
technique(s)
enzyme immunoassay: suitable
impurities
≤0.1% hPRL (weight), ≤0.2% hGH, hFSH (weight), ≤0.3% hLH (weight)
solubility
0.05 M PBS: 1 mg/mL
shipped in
ambient
storage temp.
−20°C
Gene Information
human ... TSHB(7252)
General description
Research area: Cell Signaling
Thyroid Stimulating Hormone is a glycoprotein produced by anterior pituitary gland. Its structure contains an alpha chain and a beta chain.
Thyroid Stimulating Hormone is a glycoprotein produced by anterior pituitary gland. Its structure contains an alpha chain and a beta chain.
Biochem/physiol Actions
Thyroid stimulating hormone It exerts mild, continuous stimulation on the thyroid, resulting in maintenance of activity. TSH modulates the release of T3 and T4 from thyroid follicular cells. Thyroid Stimulating Hormone (TSH) primary targets thyroid gland and maintains thyroid activity. It regulates the release of T3 and T4 hormones from thyroid follicular cells. TSH binds to the TSH receptor (TSHR) and trigger Gs and Gq pathways. Activation of the Gs pathway stimulates iodide uptake, hormone secretion, and gland growth. The Gq pathway is involved in iodide organification for hormone synthesis. TSH secretion is inhibited by Somatostatin. Overexpression of TSH leads to hyperthyroidism, whereas lower TSH expression leads to hypothyroidism.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Prepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Other Notes
1mg/ml in 0.05M PBS
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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The potency specification of this product is ≥6.0 IU/mg. The batch-specific Certificate of Analysis reports the potency.
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