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N-Ethyldiisopropylamine solution

Name: <I>N</I>-Ethyldiisopropylamine solution
Brand: SIAL

~2 M in 1-methyl-2-pyrrolidinone, solution, suitable for peptide synthesis

Synonym(s):

N,N-Diisopropylethylamine, DIPEA, Hünig’s base

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About This Item

Empirical Formula (Hill Notation):

C₈H₁₉N

CAS Number:

7087-68-5

Molecular Weight:

129.24

NACRES:

NA.21

PubChem Substance ID:

329747633

UNSPSC Code:

12352100

MDL number:

MFCD00008868

Beilstein/REAXYS Number:

4124745

Form:

liquid

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Properties

Product Name

N-Ethyldiisopropylamine solution, suitable for peptide synthesis, ~2 M in 1-methyl-2-pyrrolidinone

form

liquid

Quality Level

100

concentration

~2 M in 1-methyl-2-pyrrolidinone

impurities

≤0.2% water (KFT)

refractive index

n20/D 1.454

application(s)

peptide synthesis

functional group

amine

SMILES string

CCN(C(C)C)C(C)C

InChI

1S/C8H19N/c1-6-9(7(2)3)8(4)5/h7-8H,6H2,1-5H3

InChI key

JGFZNNIVVJXRND-UHFFFAOYSA-N

Description

General description

N-Ethyldiisopropylamine (EDIA) reacts with monoactivated Michael acceptors to afford symmetrical sulfones.

Application

N,N-Diisopropylethylamine (DIPEA), also known as Hünig′s base, is a sterically hindered amine. It is commonly employed as a base in peptide synthesis. Additionally, DIPEA is also used in the Pd-catalyzed cross-coupling reactions, which include Heck coupling and Sonagashira coupling reactions.

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This Item	D125806	214914
Sigma-Aldrich 03439 N-Ethyldiisopropylamine solution	Sigma-Aldrich D125806 N,N-Diisopropylethylamine	Sigma-Aldrich 214914 N,N-Dimethylmethyleneiminium iodide
Quality Level 100	Quality Level 200	Quality Level 100
refractive index n20/D 1.454	refractive index n20/D 1.414 (lit.)	refractive index -
form liquid	form liquid	form -
concentration ~2 M in 1-methyl-2-pyrrolidinone	concentration -	concentration -
impurities ≤0.2% water (KFT)	impurities -	impurities -
application(s) peptide synthesis	application(s) -	application(s) -

pictograms

GHS02,GHS06,GHS08,GHS05,GHS09

signalword

Danger

hcodes

H226,H302,H315,H318,H331,H335,H360D,H411

pcodes

P210 - P273 - P280 - P304 + P340 + P311 - P305 + P351 + P338 - P308 + P313

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Flam. Liq. 3 - Repr. 1B - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

3 - Flammable liquids

wgk

WGK 2

flash_point_f

73.4 °F

flash_point_c

23 °C

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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Eugene F, et al.

The Journal of Organic Chemistry, 59(9), 2599-2603 (1994)

An automatic reaction control chemical ionization technique in ion trap detector for quantitative plasma profding of arecoline in treated alzheimer patients.

H U Shetty et al.

Journal of the American Society for Mass Spectrometry, 2(2), 168-173 (1991-04-01)

An automatic reaction control chemical ionization technique in an ion trap detector (lTD) was used to quantitate the levels of the cholinergic drug, arecoline, in plasma of treated patients with Alzheimer's disease. The chemical ionization reaction was carried out with

Ratiometric pH-nanosensors based on rhodamine-doped silica nanoparticles functionalized with a naphthalimide derivative.

Tristan Doussineau et al.

Journal of colloid and interface science, 339(1), 266-270 (2009-08-15)

This paper describes the preparation of two-dye-doped silica nanoparticles for ratiometric pH measurements in the biologically relevant pH-range. While a rhodamine derivative is embedded in a silica core and used as the reference, a pH-sensitive naphthalimide dye is immobilized on