Curcumin is generally more soluble in pure ethanol. Ethanol's ability to dissolve curcumin is enhanced due to non-polar characteristics, which can effectively interact with the non-polar regions of curcumin. While curcumin is soluble in 70% ethanol, solubility is typically lower than in 100% ethanol.
08511
Curcumin
analytical standard
Synonym(s):
(E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, Diferuloylmethane, Diferulylmethane, Natural Yellow 3
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About This Item
Linear Formula:
[HOC6H3(OCH3)CH=CHCO]2CH2
CAS Number:
Molecular Weight:
368.38
UNSPSC Code:
85151701
NACRES:
NA.24
E Number:
E100
PubChem Substance ID:
EC Number:
207-280-5
MDL number:
Colour Index Number:
75300
Beilstein/REAXYS Number:
2306965
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grade
analytical standard
Quality Level
vapor density
13 (vs air)
assay
≥98.0% (HPLC)
form
powder
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
cleaning products
cosmetics
food and beverages
personal care
format
neat
storage temp.
2-8°C
SMILES string
COc1cc(\C=C\C(=O)CC(=O)\C=C\c2ccc(O)c(OC)c2)ccc1O
InChI
1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+
InChI key
VFLDPWHFBUODDF-FCXRPNKRSA-N
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1 of 4
This Item | |||
|---|---|---|---|
| grade analytical standard | grade certified reference material, pharmaceutical secondary standard | grade - | grade primary reference standard |
| technique(s) HPLC: suitable, gas chromatography (GC): suitable | technique(s) - | technique(s) - | technique(s) HPLC: suitable, gas chromatography (GC): suitable |
| format neat | format - | format - | format - |
| assay ≥98.0% (HPLC) | assay - | assay - | assay - |
| vapor density 13 (vs air) | vapor density 13 (vs air) | vapor density 13 (vs air) | vapor density 13 (vs air) |
| form powder | form solid | form powder | form powder or crystals |
General description
Curcumin is an anti-inflammatory agent extracted from the roots of Curcuma longa Linn.
Application
Curcumin may be used as a reference standard for the determination of curcumin in rat plasma by high-performance liquid chromatography method.
Biochem/physiol Actions
A natural phenolic compound responsible for the yellow color of turmeric. Potent anti-tumor agent that acts against highly diverse tumor-specific pathways. Anti-inflammatory and anti-oxidant. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cyclooxygenase (COX-2) and 5-lipoxygenase (5-LOX).
A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Curcumin has been cited as a potential chemopreventive agent, in addition to its chemotherapeutic activity. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Other Notes
This compound is commonly found in plants of the genus: curcuma
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Oxygen radical scavenging activity of curcumin.
Kunchandy E and Rao MNA
International Journal of Pharmaceutics, 58(3), 237-240 (1990)
A rapid and simple HPLC method for the determination of curcumin in rat plasma: assay development, validation and application to a pharmacokinetic study of curcumin liposome.
Li J, et al.
Biomedical Chromatography, 23(11), 1201-1207 (2009)
Phase I clinical trial of curcumin, a chemopreventive agent, in patients with highrisk or pre-malignant lesions.
Hsieh CY.
Anticancer Research, 21, 2895-2900 (2001)
Yoshikane Yamauchi et al.
Phytotherapy research : PTR, 28(5), 728-735 (2013-08-15)
Resistance to erlotinib in lung cancer cases includes T790M mutant epidermal growth factor receptor and c-Met gene amplification, but other unknown mechanisms account for about 30% of the resistance. Activation of the nuclear factor kappa B (NFkappaB)-related pathways in association
Bharat B Aggarwal et al.
Molecular nutrition & food research, 57(9), 1529-1542 (2013-07-13)
Turmeric, a dried powder derived from the rhizome of Curcuma longa, has been used for centuries in certain parts of the world and has been linked to numerous biological activities including antioxidant, anti-inflammatory, anticancer, antigrowth, anti-arthritic, anti-atherosclerotic, antidepressant, anti-aging, antidiabetic
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 261939-5G | 04061838118929 |
| 261939-1G | 04061838118912 |
| 08511-10MG | 04061838652508 |
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Good morning, do you know the solubility of curcumin in 70% ethanol and absolute ethanol? Thank you in advance.
1 answer-
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