This product is available in three package size. The full product packaging information is as follows:
100 mg - packaged in a clear polypropylene vial with a polypropylene screw cap (primary packaging)
1 g - packaged in a polypropylene tube with screw cap in a poly bag (primary packaging with secondary bag)
5 g - packaged in an HDPE bottle with a polypropylene screw cap with a foam liner (primary packaging with foam-lined secondary packaging)
This product is intended for laboratory research use only, no packaging certification is available. Please see the link below to access a sample or lot-specific Certificate of Analysis:
https://www.sigmaaldrich.com/product/sial/14400#product-documentation
14400
Biotin
≥99.0% (T)
Synonym(s):
D-Biotin, Bios II, Coenzyme R, Vitamin B7, Vitamin H
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| Size/SKU | Availability | Price |
|---|---|---|
100 mg | Check Cart for Availability | $51.90 |
1 g | Check Cart for Availability | $144.00 |
5 g | Check Cart for Availability | $510.00 |
About This Item
Empirical Formula (Hill Notation):
C10H16N2O3S
CAS Number:
Molecular Weight:
244.31
NACRES:
NA.21
PubChem Substance ID:
eCl@ss:
34058011
UNSPSC Code:
12352201
EC Number:
200-399-3
MDL number:
Beilstein/REAXYS Number:
86838
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biological source
synthetic
Quality Segment
assay
≥99.0% (T)
form
powder
optical activity
[α]20/D +91±2°, c = 1% in 0.1 M NaOH
ign. residue
≤0.1% (as SO4)
loss
≤0.5% loss on drying
color
colorless to white
mp
229-234 °C, 231-233 °C (lit.)
solubility
alcohol: soluble 80mg/100 ml at 25 °C, water: soluble 22mg/100 ml at 25 °C, 0.1 M NaOH: 10 mg/mL at 25 °C, clear, colorless, H2O: very soluble, organic solvents: insoluble
cation traces
Ca: ≤50 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤10 mg/kg, K: ≤50 mg/kg, Mg: ≤5 mg/kg, Mn: ≤5 mg/kg, Na: ≤500 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Zn: ≤5 mg/kg
SMILES string
[H][C@]12CS[C@@H](CCCCC(O)=O)[C@@]1([H])NC(=O)N2
application(s)
detection
InChI
1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1
InChI key
YBJHBAHKTGYVGT-ZKWXMUAHSA-N
General description
Biotin is readily available in several foods, like whole grains, nuts, legumes, unpolished rice and egg yolk. The normal gut flora also produces this vitamin.
Application
Biochem/physiol Actions
Biotin also referred to as vitamin H or vitamin B7 is a water-soluble B-vitamin that induces two to three fold increase in guanylate cyclase activity in rat liver, kidney, colon, cerebellum, and heart. It also stimulates the sperm motility and prolongs the survival of cryopreserved human spermatozoa.
Biotin acts as an important cofactor for carboxylase enzymes in various metabolic pathways. Biotin favors keratin synthesis and hence is used as a supplement for hair and nail growth. Deficiency of biotin shows several symptoms such as alopecia, conjunctivitis, seborrheic dermatitis, depression, lethargy, hypotonia and seizures.
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This Item | |||
|---|---|---|---|
| description ≥99.0% (T) | description certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland | description United States Pharmacopeia (USP) Reference Standard | description powder, BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥99% |
| assay ≥99.0% (T) | assay - | assay - | assay ≥99% |
| biological source synthetic | biological source - | biological source - | biological source - |
| application(s) detection | application(s) clinical testing | application(s) pharmaceutical (small molecule) | application(s) - |
| form powder | form - | form - | form powder |
| solubility organic solvents: insoluble, 0.1 M NaOH: 10 mg/mL at 25 °C, clear, colorless, H2O: very soluble, water: soluble 22mg/100 ml at 25 °C, alcohol: soluble 80mg/100 ml at 25 °C | solubility - | solubility - | solubility H2O: 0.2 mg/mL (Solubility increases with addition of 1 N NaOH.) |
| color colorless to white | color white | color - | color white to off-white |
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Storage Class
11 - Combustible Solids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
Eyeshields, Gloves, type N95 (US)
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What are the primary and secondary packaging types, as well as the certification, for SKU 14400?
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How can I determine the shelf life / expiration / retest date of this product?
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If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdfHelpful?
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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