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Histamine dihydrochloride

Name: Histamine dihydrochloride
Brand: SIGMA
Price: 29.8 CAD

≥99.0% (AT), powder or crystals, endogenous histamine receptor agonist

Synonym(s):

2-(4-Imidazolyl)ethylamine dihydrochloride

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Pack Size	Availability	Price
1 g	Please contact Customer Service for Availability	$29.80
5 g	Please contact Customer Service for Availability	$102.00
25 g	Please contact Customer Service for Availability	$322.00

About This Item

Empirical Formula (Hill Notation):

C₅H₉N₃ · 2HCl

CAS Number:

56-92-8

Molecular Weight:

184.07

NACRES:

NA.77

PubChem Substance ID:

329757931

eCl@ss:

32160406

UNSPSC Code:

12352116

EC Number:

200-298-4

MDL number:

MFCD00012703

Beilstein/REAXYS Number:

3624116

Assay:

≥99.0% (AT)

Form:

powder or crystals

$29.80

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Properties

Product Name

Histamine dihydrochloride, ≥99.0% (AT)

assay

≥99.0% (AT)

form

powder or crystals

ign. residue

≤0.2%

loss

≤0.2% loss on drying, 20 °C (HV)

mp

244-247 °C, 249-252 °C (lit.)

solubility

H₂O: 0.1 g/mL, clear, colorless

anion traces

sulfate (SO₄^2-): ≤200 ppm

cation traces

Ca: ≤10 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, K: ≤50 mg/kg, Mg: ≤5 mg/kg, Mn: ≤5 mg/kg, Na: ≤50 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Zn: ≤5 mg/kg

SMILES string

Cl[H].Cl[H].NCCc1c[nH]cn1

InChI

1S/C5H9N3.2ClH/c6-2-1-5-3-7-4-8-5;;/h3-4H,1-2,6H2,(H,7,8);2*1H

InChI key

PPZMYIBUHIPZOS-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269)

Description

General description

Histamine is a hydrophilic amine derived from the decarboxylation of histidine by the enzyme L-histidine decarboxylase. Histamine has been shown to play a role in many physiological processes such as gastric secretion, neurotransmission, immune response, vasodialation, and inflammation. Additionally, studies have reported a role for histamine dihydrochloride with interleukin-2 (IL-2) in treatment of acute myeloid leukemia and in protection against alcohol-induced liver injury in rats[1].

Biochem/physiol Actions

Endogenous H₁ and H₂ histamine receptor agonist; activates nitric oxide synthetase; potent vasodilator.

Histamine dihydrochloride has been shown to activate nitric oxide synthetase and suppress or inhibit the generation of reactive oxygen species (ROS). Inhibition of ROS by histamine dihydrochloride allows activation of T cells and NK cells by IL-2[2]. In a rat model, histamine dihydrochloride suppressed ROS generated by Kupffer cells through the H₂ histamine receptor[1].

Other Notes

Substrate for the assay of histamine-N-methyltransferase (EC 2.1.1.8); Ion-pair extraction of histamine from biological fluids for its determination by HPLC with fluorescence detection.

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This Item	H0600000	1309009	H7250
Sigma-Aldrich 53300 Histamine dihydrochloride	H0600000 Histamine dihydrochloride	USP 1309009 Histamine dihydrochloride	Sigma-Aldrich H7250 Histamine dihydrochloride
assay ≥99.0% (AT)	assay -	assay -	assay ≥99% (TLC)
form powder or crystals	form -	form -	form powder
solubility H₂O: 0.1 g/mL, clear, colorless	solubility -	solubility -	solubility -
loss ≤0.2% loss on drying, 20 °C (HV)	loss -	loss -	loss -
anion traces sulfate (SO₄^2-): ≤200 ppm	anion traces -	anion traces -	anion traces -
cation traces Ca: ≤10 mg/kg, Co: ≤5 mg/kg, Cu: ≤5 mg/kg, K: ≤50 mg/kg, Mn: ≤5 mg/kg, Ni: ≤5 mg/kg, Zn: ≤5 mg/kg, Cd: ≤5 mg/kg, Fe: ≤5 mg/kg, Na: ≤50 mg/kg, Cr: ≤5 mg/kg, Pb: ≤5 mg/kg, Mg: ≤5 mg/kg	cation traces -	cation traces -	cation traces -

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Explore all of our products under Histamine dihydrochloride

pictograms

GHS08,GHS07

signalword

Danger

hcodes

H315,H317,H319,H334,H335

pcodes

P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Histamine dihydrochloride protects against early alcohol-induced liver injury in a rat model.

Stephen C Hornyak et al.

Inflammation, 27(5), 317-327 (2003-11-26)

Inflammation of the liver may be caused by a variety of factors that include infectious agents and toxins. Reactive oxygen species (ROS) generated by the NADPH oxidase in Kupffer cells and infiltrating leukocytes play an important role in the pathogenesis

J. Axelrod

Methods in Enzymology, 17B, 766-766 (1971)

Spotlight on histamine dihydrochloride in acute myeloid leukaemia.

Lily P H Yang et al.

Drugs & aging, 28(4), 325-329 (2011-03-25)

Histamine dihydrochloride (Ceplene®) is a synthetic derivative of the biogenic amine histamine. Histamine dihydrochloride inhibits the formation of reactive oxygen species that suppress the activation of T cells and natural killer (NK) cells. When given in addition to the cytokine

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Global Trade Item Number

SKU	GTIN
W514500-10KG-K	04061837521126
PHR1081-1G	04061837883965
PHR1081-10G	04061835232888
1477943-400MG	04061838737540
437379-100ML	04061832118727
W514500-SAMPLE-K	04061837521140
W514500-1KG-K	04061837521133
52184-1ML	04061832547404
53300-2G-KC	04061832089027
53300-5G	04061835258147
53300-25G	04061832559117
53300-1G	04061832559100

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