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E4013

モノクロナール抗エラスチンマウス宿主抗体

Name: モノクロナール抗エラスチン マウス宿主抗体
Brand: SIGMA
Price: 28000 JPY

clone BA-4, ascites fluid

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あなたへ/カタログ番号	在庫状況	単価
25 μL	カートの在庫状況を確認する	￥28,000
100 μL	カートの在庫状況を確認する	￥82,200

この商品について

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD00164587

Conjugate:

unconjugated

Clone:

BA-4, monoclonal

Application:

ARR, IHC (p)

Citations:

￥28,000

カートの在庫状況を確認する

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特性

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

BA-4, monoclonal

mol wt

antigen 67.5 kDa

contains

15 mM sodium azide

species reactivity

human, goat, sheep, guinea pig, pig, canine, feline, bovine

packaging

antibody small pack of 25 μL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:5,000 using sheep arterial tissue, microarray: suitable

isotype

IgG1

UniProt accession no.

P15502

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ELN(2006)

詳細

General description

Monoclonal Anti-Elastin (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Elastin is an important polymeric protein of connective tissue. It is synthesized and secreted as a soluble single-chain protein (tropoelastin) that undergoes numerous post-ribosomal modifications prior to the organization of the elastic fiber in the extracellular space.

Immunogen

ウシα-エラスチン

Application

Monoclonal Anti-Elastin antibody produced in mouse has been used in:

immunohistochemistry
immunostaining
immunoblotting

Biochem/physiol Actions

本抗体は不溶性エラスチン、α-エラスチン、トロポエラスチン (エラスチンの非架橋可溶性前駆体) 、不溶性エラスチンのタンパク質分解で生じるペプチドフラグメントに結合します。トロポエラスチ調製物の場合、エラスチンの3つのアイソフォ-ムに対応する3本のバンド (67.5kDa, 65kDa, 62kDa) を検出します。この抗体はエラスチンの繰返し配列から構成されるエピト-プ (Val-Gly-Val-Ala-Pro-Gly) に特異的です。このエピト-プは線維芽細胞および単球に対する化学誘引物質であることが示されています。

Elastin is encoded by the ELN gene in humans. It is a polymeric protein in connective tissue that has exceptional properties of extension, elastic recoil to the extracellular matrix and allows many tissues in the body to resume their shape after stretching or contracting. Elastin is a self-assembling, extracellular-matrix protein providing tissue elasticity and is predominantly comprised of cross-linked tropoelastin. It plays an important role in the atherosclerotic process. The conformational disorder is caused due to a constitutive feature of elastin structure and function.

Elastin undergoes changes of morphology with aging and in many disease states. For example, abnormal accumulation of connective tissue in blood vessels contributes to alterations in vascular physiology associated with diseases such as hypertension and atherosclerosis. Several heritable diseases such as Marfan syndrome, pseudoxanthoma elasticum and the Buschke-Ollendorf syndrome may result from molecular defects of elastin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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当該品目	M7786	G4896	T2780
Sigma-Aldrich E4013 モノクロナール抗エラスチンマウス宿主抗体	Sigma-Aldrich M7786 モノクロナール抗ミオシン (平滑筋型) マウス宿主抗体	Sigma-Aldrich G4896 モノクロナール抗ゲルゾリンマウス宿主抗体	Sigma-Aldrich T2780 モノクロナール抗トロポミオシンマウス宿主抗体
antibody form ascites fluid	antibody form ascites fluid	antibody form ascites fluid	antibody form ascites fluid
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
species reactivity human, goat, sheep, guinea pig, pig, canine, feline, bovine	species reactivity guinea pig, human, pig, canine, rabbit, chicken	species reactivity bovine, pig, human, rabbit	species reactivity pig, chicken, bovine, rabbit, mouse, hamster, rat, human
Gene Information human ... ELN(2006)	Gene Information human ... MYH11(4629)	Gene Information human ... GSN(2934)	Gene Information bovine ... TPM1(281544) chicken ... TPM1(396366) human ... TPM1(7168) mouse ... Tpm1(22003) rat ... Tpm1(24851)
biological source mouse	biological source mouse	biological source mouse	biological source mouse
clone BA-4, monoclonal	clone hSM-V, monoclonal	clone GS-2C4, monoclonal	clone TM311, monoclonal

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保管分類

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c