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Anti-Parvalbumin antibody, Mouse monoclonal

Name: Anti-Parvalbumin antibody, Mouse monoclonal
Brand: SIGMA
Price: 591 USD
Availability: InStock

clone PARV-19, purified from hybridoma cell culture

Synonym(s):

Monoclonal Anti-ALPHA-PARVALBUMIN, Monoclonal Anti-PALB1, Monoclonal Anti-PV, Monoclonal Anti-PVALB (includes EG:19293), Monoclonal Anti-Parv, Monoclonal Anti-Pva

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Size/SKU	Availability	Price
200 μL	Available to ship TODAYfromMILWAUKEE	$591.00

About This Item

NACRES:

NA.44

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

PARV-19, monoclonal

Application:

IF, WB

Citations:

$591.00

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Properties

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

PARV-19, monoclonal

form

buffered aqueous solution

mol wt

antigen 12 kDa

species reactivity

rat, human

concentration

~1.0 mg/mL

technique(s)

indirect immunofluorescence: 10-20 μg/mL using BLO-11 cells., western blot: 1-2 μg/mL using mouse muscle extracts.

isotype

IgG1

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PVALB(5816)
rat ... PVALB(25269)

Description

General description

Monoclonal Anti-Parvalbumin (mouse IgG1 isotype) is derived from the hybridoma PARV-19 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with purified frog muscle parvalbumin. Parvalbumin (PV) is a member of the family of Ca²⁺-binding molecules. It carries three helix-loop-helix EF-hand Ca²⁺ binding motifs, with the two C-terminal motifs.

Immunogen

purified frog muscle parvalbumin. The isotype is determined by ELISA using Mouse Monoclonal Antibody Isotyping Reagents (Sigma ISO-2).

Application

Anti-Parvalbumin antibody, Mouse monoclonal has been used in:

immunohistochemistry
immunofluorescence staining
immunolabeling
to label brain slices for perineuronal net staining
enzyme-linked immunosorbent assay (ELISA)
immunocytochemistry

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Biochem/physiol Actions

Ca²⁺ participates in cell motility, release of neurotransmitters, membrane permeability, excitation−contraction of muscles, cell secretory procedures, and transmission of nerve impulses. Intracellular Ca²⁺ exchangers are essential to modulate these processes efficiently. Parvalbumin (PV), a calcium-binding protein, can regulate the intracellular calcium dynamics in neurons. Hence it may have an impact on facilitation and depression at synapses. Interestingly, PV deficiency alters neuronal activity, a key mechanism leading to epileptic seizures or Parkinson.

Monoclonal Anti-Parvalbumin recognizes parvalbumin in a Ca2+ -ion dependent manner

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Preparation Note

For extended storage, freeze at –20 °C in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	P3088	SAB4200543	SAB4200365
Sigma-Aldrich SAB4200545 Anti-Parvalbumin antibody, Mouse monoclonal	Sigma-Aldrich P3088 Monoclonal Anti-Parvalbumin antibody produced in mouse	Sigma-Aldrich SAB4200543 Anti-Calbindin-D-28K antibody, Mouse monoclonal	Sigma-Aldrich SAB4200365 Anti-PIWIL1 antibody, Mouse monoclonal
description clone PARV-19, purified from hybridoma cell culture	description clone PARV-19, ascites fluid	description clone CB-955, purified from hybridoma cell culture	description clone PIWIL1-2, purified from hybridoma cell culture
clone PARV-19, monoclonal	clone PARV-19, monoclonal	clone CB-955, monoclonal	clone PIWIL1-2, monoclonal
biological source mouse	biological source mouse	biological source mouse	biological source mouse
Gene Information human ... PVALB(5816) rat ... PVALB(25269)	Gene Information human ... PVALB(5816) rat ... Pvalb(25269)	Gene Information human ... CALB1(793)	Gene Information human ... PIWIL1(9271) mouse ... Piwil1(57749)
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
species reactivity rat, human	species reactivity fish, frog, rabbit, canine, feline, bovine, pig, human, goat, rat	species reactivity mouse, human, rat	species reactivity human, mouse
antibody form purified from hybridoma cell culture	antibody form ascites fluid	antibody form purified immunoglobulin	antibody form purified from hybridoma cell culture

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c