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A1960

Aggrecan from bovine articular cartilage

lyophilized powder

Synonym(s):

Aggrecan Protein

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Size/SKUAvailabilityPrice
1 mg

Available to ship TODAYfromMILWAUKEE

$438.00

About This Item

UNSPSC Code:
12352202
NACRES:
NA.75
MDL number:
MFCD00676441
Form:
lyophilized powder
Biological source:
bovine articular cartilage

$438.00

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biological source

bovine articular cartilage

Quality Segment

200

form

lyophilized powder

packaging

glass bottle of 1 mg

technique(s)

cell culture | mammalian: suitable

impurities

salt, essentially free

color

white

solubility

H2O: 2 mg/mL

UniProt accession no.

P13608

shipped in

wet ice

storage temp.

−20°C

Gene Information

cow ... AGC1(280985)

Application

Aggrecan is a critical component for cartilage structure and the function of joints. Its synthesis and degradation are being studied for their roles in cartilage deterioration during joint injury disease and aging.

Biochem/physiol Actions

This molecule produces a rigid, reversibly deformable gel that resists compression. It combines with hyaluronic acid to form very large macromolecular complexes that have an increased hydrohynamic volume and a significant increase (30-40%) in the relative viscosity of the solution.

Preparation Note

This product is extracted from articular cartilage, chematographically purified, dialyzed against water, and 0.2 μm filtered prior to lyophilization. Once lyophilized, this powder is essentially salt-free. The product is soluble in water at 2 mg/mL.

Other Notes

Aggrecan is a major structural proteoglycan of the cartilage extracellular matrix. It is a large proteoglycan, with a molecular weight greater than 2,500 kDa composed of approximately 100-150 glycosaminoglycan chains attached to a core protein. The majority of these glycosaminoglycan chains are chondroitin/dermatan sulfate. Aggrecan contains three globular domains, G1, G2, and G3, which are involved in aggregation and hylauronan binding, cell adhesion and chondrycte apoptosis.

Disclaimer

Store this product at -20°C. Stored as supplied, this powder shows little decomposition in 3 years when stored properly.

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Aggrecan from bovine articular cartilage lyophilized powder

Sigma-Aldrich

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Sigma-Aldrich

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apo-Transferrin bovine ≥98%

Sigma-Aldrich

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Concanavalin A from Canavalia ensiformis (Jack bean) Type IV-S, lyophilized powder, γ-irradiated, BioReagent, suitable for cell culture

Sigma-Aldrich

C0412

Concanavalin A from Canavalia ensiformis (Jack bean)

description

lyophilized powder

description

salt-free, lyophilized powder

description

≥98%

description

Type IV-S, lyophilized powder, γ-irradiated, BioReagent, suitable for cell culture

biological source

bovine articular cartilage

biological source

bovine articular cartilage

biological source

bovine

biological source

-

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

form

lyophilized powder

form

salt-free, lyophilized powder

form

powder

form

lyophilized powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

H2O: 2 mg/mL

solubility

PBS: ≥2.00 mg/mL, clear, colorless to yellow

solubility

H2O: 20 mg/mL

solubility

PBS: 5 mg/mL, slightly hazy, H2O: soluble, slightly hazy

impurities

salt, essentially free

impurities

-

impurities

-

impurities

salt, essentially free

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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