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D8428

Decorin from bovine articular cartilage

salt-free, lyophilized powder

Synonym(s):

Decorin protein

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0.5 MG

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About This Item

MDL number:
MFCD00283027
UNSPSC Code:
12352202
NACRES:
NA.75

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biological source

bovine articular cartilage

Quality Level

200

form

salt-free, lyophilized powder

mol wt

~100 kDa

packaging

glass bottle of 0.5 mg

technique(s)

cell culture | mammalian: suitable

solubility

PBS: ≥2.00 mg/mL, clear, colorless to yellow

UniProt accession no.

P21793

storage temp.

−20°C

Gene Information

cow ... DCN(280760)

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This Item
B8041C1188C9301
Decorin from bovine articular cartilage salt-free, lyophilized powder

Sigma-Aldrich

D8428

Decorin from bovine articular cartilage

Biglycan from bovine articular cartilage essentially salt-free, lyophilized powder

Sigma-Aldrich

B8041

Biglycan from bovine articular cartilage

Collagen from bovine tracheal cartilage Bornstein and Traub Type II, powder

Sigma-Aldrich

C1188

Collagen from bovine tracheal cartilage

Collagen from chicken sternal cartilage Type II (Miller), powder, BioReagent, suitable for cell culture

Sigma-Aldrich

C9301

Collagen from chicken sternal cartilage

biological source

bovine articular cartilage

biological source

bovine articular cartilage

biological source

bovine cartilage (tracheal)

biological source

chicken (Sternal cartilage)

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

-

technique(s)

cell culture | mammalian: suitable

form

salt-free, lyophilized powder

form

essentially salt-free, lyophilized powder

form

powder

form

powder

mol wt

~100 kDa

mol wt

200-350 kDa

mol wt

-

mol wt

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

Gene Information

cow ... DCN(280760)

Gene Information

cow ... BGN(280733)

Gene Information

cow ... COL2A1(407142)

Gene Information

chicken ... COL2A1(395069)

General description

Decoran is a small proteoglycan composed of a chondroitin/dermatan sulfate glycosaminoglycans attached to a 40 kDa core protein. It is found primarily in the extracellular matrix of articular cartilage. Decorin interacts with collagen types I and II via its core protein wherein it delays fibrillogenesis. Decorin also interacts with fibronectin, thrombospondin and TGF-β isoforms, and the EGF-receptor.
Decorin from bovine articular cartilage is a proteoglycan that belongs to the small leucine-rich repeat proteoglycans and proteins (SLRPs) family. Decorin is present in almost all tissues.[1] It has a protein core composed of leucine-rich repeats (LRRs), flanked by two cysteine-rich regions.[2]

Application

Decorin from bovine articular cartilage has been used in solid phase binding assay (ELISA)[3], binding assays[4], binding inhibition assay[5], parasite binding assays[6], scaffold fabrication[7], quartz crystal microbalance assay[8], inhibition of CSA (chondroitin sulphate A) binding assay[9] and glycans and glycan biotinylation.[10]

Biochem/physiol Actions

Decorin plays an important role in guiding the proper assembly of collagen during fibrillogenesis.[1] Deficiency in decorin results in altered tissue structure and function. It controls growth factors like EGF and TGF-β. Decorin blocks aggregation of fibrils into fibers and fibrillogenesis in cell-free constructs of polymerized type I collagen.[1]

Other Notes

Decorin is an approx. 100 kDa proteoglycan consisting of a 40 kDa core protein and one chondroitin or dermatan sulfate glycosaminoglycan chain. From 0.2 μm filtered solution prior to lyophilization.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000335441
0000335441
0000209565
0000209565
0000135207

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Several domains from VAR2CSA can induce Plasmodium falciparum adhesion-blocking antibodies.
Salanti A, et al.
Malaria Journal, 9(1), 11-11 (2010)
Functional and immunological characterization of the var2CSA-DBL5? domain of a placental Plasmodium falciparum isolate.
Gangnard S, et al.
Molecular and Biochemical Parasitology, 173(2), 115-122 (2010)
Effects of decorin proteoglycan on fibrillogenesis, ultrastructure, and mechanics of type I collagen gels.
Reese S P, et al.
Matrix Biology, 32(7-8), 414-423 (2013)
Full-length recombinant Plasmodium falciparum VAR2CSA binds specifically to CSPG and induces potent parasite adhesion-blocking antibodies.
Khunrae P, et al.
Journal of Molecular Biology, 397(3), 826-834 (2010)
Induction of adhesion-inhibitory antibodies against placental Plasmodium falciparum parasites by using single domains of VAR2CSA.
Nielsen M A, et al.
Infection and Immunity, 77(6), 2482-2487 (2009)
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