This material is not a fat-soluble molecule. The product is water soluble at 100 mg/mL.
A7007
S-(5′-Adenosyl)-L-methionine chloride dihydrochloride
≥75%
Synonym(s):
SAM, Active methionine, AdoMet, SAM chloride dihydrochloride
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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Estimated to ship TODAYfromSAINT LOUIS | $81.30 |
25 mg | Estimated to ship TODAYfromSAINT LOUIS | $106.00 |
100 mg | Estimated to ship TODAYfromSAINT LOUIS | $261.00 |
500 mg | Estimated to ship onAugust 20, 2026fromSAINT LOUIS | $930.00 |
1 g | Estimated to ship TODAYfromSAINT LOUIS | $1,490.00 |
About This Item
Empirical Formula (Hill Notation):
C15H23ClN6O5S · 2 HCl
CAS Number:
Molecular Weight:
507.82
UNSPSC Code:
12352209
NACRES:
NA.32
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
6560002
Form:
powder
Assay:
≥75%
Solubility:
H2O: 100 mg/mL
Biological source:
synthetic (chemical)
Color:
white to off-white
$81.30
Estimated to ship TODAYDetails
biological source
synthetic (chemical)
Quality Segment
assay
≥75%
form
powder
color
white to off-white
solubility
H2O: 100 mg/mL
application(s)
cell analysis
shipped in
dry ice
storage temp.
−20°C
SMILES string
Cl.Cl.[Cl-].C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23
InChI
1S/C15H22N6O5S.3ClH/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21;;;/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25);3*1H/t7-,8+,10+,11+,14+,27?;;;/m0.../s1
InChI key
KBAFOJZCBYWKPU-XQVUROGGSA-N
General description
S-(5′-Adenosyl)-L-methionine chloride dihydrochloride (SAM) facilitates the transfer of methyl groups to proteins, lipids and nucleic acids. Methionine adenosyl transferase catalyses the synthesis of SAM from methionine and adenosine triphosphate (ATP). SAM functions to regulate various cellular functions like cell division, cell death, transcription, genetic stability, oxidant/antioxidant balance and polyamine homeostasis. Therapeutically, SAM finds its application as a nutritional supplement in humans for various diseases like osteoarthritis and liver injury. SAM also regulates transsulfuration reactions by binding to the regulatory domain of key enzyme cystathionine-β-synthase (CBS).
Application
S-(5′-Adenosyl)-L-methionine chloride dihydrochloride has been used as a medium supplement for S30 cell extract. It also has been used for measuring the interaction with catechol-O-methyltransferase (COMT) by quartz crystal microbalance (QCM), surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC) with supported lipid bilayers and vesicles.
Biochem/physiol Actions
Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT).
Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury.
Analysis Note
Purity based on UV and HPLC.
Disclaimer
This material is 80-90% pure when prepared, but is very unstable. As much as 10% purity loss per day at 25 °C has been noted.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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