This product is unconjugated bilirubin described as free bilirubin.
B4126
Bilirubin
≥98% (EmM/453 = 60), powder
Synonym(s):
Bile pigment, Hemetoidin
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| Size/SKU | Availability | Price |
|---|---|---|
1 g | Please contact Customer Service for Availability | 4 000,00 kr |
5 g | Please contact Customer Service for Availability | 15 410,00 kr |
About This Item
Empirical Formula (Hill Notation):
C33H36N4O6
CAS Number:
Molecular Weight:
584.66
UNSPSC Code:
12352202
NACRES:
NA.77
PubChem Substance ID:
EC Number:
211-239-7
Beilstein/REAXYS Number:
74376
MDL number:
Assay:
≥98% (EmM/453 = 60)
Form:
powder
description
mixed isomers
Quality Segment
assay
≥98% (EmM/453 = 60)
form
powder
solubility
aqueous acid: soluble, aqueous base: soluble, benzene: soluble, chloroform: soluble
storage temp.
−20°C
SMILES string
CC1=C(C=C)\C(NC1=O)=C\c2[nH]c(Cc3[nH]c(\C=C4/NC(=O)C(C=C)=C4C)c(C)c3CCC(O)=O)c(CCC(O)=O)c2C
InChI
1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/b26-13-,27-14-
InChI key
BPYKTIZUTYGOLE-IFADSCNNSA-N
General description
Bilirubin, an end product of heme catabolism, forms from the breakdown of erythrocyte hemoglobin in the reticuloendothelial system. Heme oxygenase converts the heme of hemoglobin to biliverdin, and subsequently an NADPH-dependent biliverdin reductase converts biliverdin to bilirubin.
Bilirubin is commonly found bound to serum albumin, when circulating in blood, in its dianion form. Bilirubin is also associated with bile salts, in its monoanion form.
Disorders of hyperbilirubinemia may occur due to increased bilirubin synthesis or decreased bilirubin clearance.
Bilirubin is commonly found bound to serum albumin, when circulating in blood, in its dianion form. Bilirubin is also associated with bile salts, in its monoanion form.
Disorders of hyperbilirubinemia may occur due to increased bilirubin synthesis or decreased bilirubin clearance.
Application
Bilirubin has been used:
- in phantom preparation
- in in vitro experiments
- in the preparation of bilirubin solutions for infusion
Biochem/physiol Actions
Bilirubin has been studied for its properties as an endogenous antioxidant, such as for its capabilities to scavenge reactive oxygen species (ROS) and to inhibit NADPH-oxidase activity. It appears to function as an efficient peroxyl radical scavenger, protecting membrane lipids from oxidation by these radicals. At nanomolar concentrations it has been shown to protect neurons from oxidative damage.
Well over 99% of total bilirubin is transported as a conjugate with albumin. Abnormally high levels of bilirubin can cause severe neurological damage, but mildly elevated levels are linked to protection from oxidative stress.
Other Notes
A major component of hemoglobin decomposition. The principal pigment of bile, and the yellow color in jaundice.
Disclaimer
Protect from light.
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This Item | |||
|---|---|---|---|
| form powder | form powder | form solid | form - |
| assay ≥98% (EmM/453 = 60) | assay ≥95.0% (UV) | assay - | assay - |
| Quality Level 300 | Quality Level 100 | Quality Level 100 | Quality Level - |
| storage temp. −20°C | storage temp. - | storage temp. 10-30°C | storage temp. −20°C |
| solubility aqueous acid: soluble, benzene: soluble, aqueous base: soluble | solubility - | solubility chloroform: 1 mg/mL, alkaline solution: soluble | solubility - |
| description mixed isomers | description - | description RTECS - DU3038000 | description - |
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Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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is B4126 unconjugated bilirubin?
1 answer-
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Is it Conjugated Bilirubin or Unconjugated Bilirubin?
1 answer-
This product is unconjugated bilirubin, also known as free bilirubin.
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