B5556
Bay 11-7082
≥98% (HPLC), powder, NF-kB/TNF-α inhibitor
Synonym(s):
(E)-3-(4-Methylphenylsulfonyl)-2-propenenitrile
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| Size/SKU | Availability | Price |
|---|---|---|
10 mg | Check Cart for Availability | $146.00 |
About This Item
$146.00
Product Name
Bay 11-7082, ≥98% (HPLC), powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white
solubility
DMSO: >20 mg/mL, H2O: insoluble
SMILES string
Cc1ccc(cc1)S(=O)(=O)\C=C\C#N
InChI
1S/C10H9NO2S/c1-9-3-5-10(6-4-9)14(12,13)8-2-7-11/h2-6,8H,1H3/b8-2+
InChI key
DOEWDSDBFRHVAP-KRXBUXKQSA-N
Application
- a nuclear factor-kappa B (NF-kB) inhibitor to verify the action of the NF-kB signaling pathway in the production of interleukin (IL)-8
- a nuclear factor-kappa B (NF-kB) inhibitor to study the role of NF-kB activation in Mycoplasma hyorhinis -induced epithelial-mesenchymal transition (EMT) and cell migration
- a nod-like receptor family pyrin domain containing 3 (NLRP3) selective inhibitor to examine its effects on liver inflammation in mice after hematopoietic stem cell transplantation
Biochem/physiol Actions
Features and Benefits
1 of 1
This Item | |||
|---|---|---|---|
| description ≥98% (HPLC), powder | description The BAY 11-7082, also referenced under CAS 19542-67-7, controls the biological activity of TNF-α. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications. | description InSolution, ≥95%, Selectively and irreversibly inhibits the TNFα-inducible phosphorylation of IκB-α | description ≥98% (HPLC), solid |
| form powder | form solid | form liquid | form solid |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥95% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| solubility H2O: insoluble, DMSO: >20 mg/mL | solubility DMSO: 200 mg/mL | solubility - | solubility DMSO: soluble >25 mg/mL, H2O: insoluble |
| color white | color off-white | color - | color white |
2-(3-methoxyphenyl)-2-propanol | - | - | - |
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Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
Eyeshields, Gloves, type N95 (US)
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