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B6434

Bretazenil

≥96% (HPLC), solid

Synonym(s):

9H-Imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid, Ro 16-6028

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Size/SKUAvailabilityPrice
25 mg
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$1,070.00

About This Item

Empirical Formula (Hill Notation):
C19H20N3O3Br
CAS Number:
84379-13-5
Molecular Weight:
418.28
NACRES:
NA.77
PubChem Substance ID:
329773277
UNSPSC Code:
12352200
MDL number:
MFCD00866987
Assay:
≥96% (HPLC)
Form:
solid

$1,070.00

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Quality Segment

assay

≥96% (HPLC)

form

solid

color

white

solubility

DMSO: 24 mg/mL, H2O: insoluble

originator

Roche

storage temp.

2-8°C

SMILES string

[H][C@@]12CCCN1C(=O)c3c(Br)cccc3-n4cnc(C(=O)OC(C)(C)C)c24

InChI

1S/C19H20BrN3O3/c1-19(2,3)26-18(25)15-16-13-8-5-9-22(13)17(24)14-11(20)6-4-7-12(14)23(16)10-21-15/h4,6-7,10,13H,5,8-9H2,1-3H3/t13-/m0/s1

InChI key

LWUDDYHYYNNIQI-ZDUSSCGKSA-N

General description

Bretazenil, a tetracyclic imidazocarboxylic ester, is an anxi-olytic/anticonvulsant agent. It possesses a half-life of 2.5 hours and is quickly absorbed.

Application

Bretazenil has been used to determine non-specific binding due to its affinity to bind to a variety of γ-aminobutyric acid type A (GABAA) receptor subtypes (α1-3;5). It has also been used as a GABAA receptor partial agonist in the subcutaneous Alzet minipumps to treat obese agouti?related protein (AgRP)?ablated and lean naive mice to study its effect on them.

Biochem/physiol Actions

Bretazenil is capable of binding to γ-aminobutyric acid type A (GABAA) receptors that are sensitive and insensitive to diazepam. This compound possesses negligible sedative or muscle relaxant effects.
Bretazenil is a benzodiazepine partial agonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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This Item
UC430SML2749Y0000562
Bretazenil ≥96% (HPLC), solid

Sigma-Aldrich

B6434

Bretazenil

1′-Hydroxymidazolam

Sigma-Aldrich

UC430

1′-Hydroxymidazolam

iFSP1 ≥98% (HPLC)

Sigma-Aldrich

SML2749

iFSP1

vibrant-m

Y0000562

Midazolam impurity C

description

≥96% (HPLC), solid

description

-

description

≥98% (HPLC)

description

European Pharmacopoeia (EP) Reference Standard

assay

≥96% (HPLC)

assay

-

assay

≥98% (HPLC)

assay

-

form

solid

form

powder

form

powder

form

-

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

H2O: insoluble, DMSO: 24 mg/mL

solubility

-

solubility

DMSO: 2 mg/mL, clear

solubility

-

color

white

color

white to off-white

color

white to beige

color

-

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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