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C0128

α-Chloralose

Synonym(s):

1,2-O-(2,2,2-Trichloroethylidene)-α-D-glucofuranose, Anhydro-D-glucochloral, Chloralose

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About This Item

Empirical Formula (Hill Notation):
C8H11Cl3O6
CAS Number:
15879-93-3
Molecular Weight:
309.53
UNSPSC Code:
12352201
NACRES:
NA.25
PubChem Substance ID:
24892236
EC Number:
240-016-7
Beilstein/REAXYS Number:
85418
MDL number:
MFCD00005542
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form

powder

Quality Level

100

impurities

≤20% β-anomer

color

white to off-white

solubility

ethanol: 10 mg/mL, clear to slightly hazy, colorless to faintly yellow (or yellow-brown)

SMILES string

OC[C@@H](O)[C@H]1O[C@@H]2O[C@@H](O[C@@H]2[C@H]1O)C(Cl)(Cl)Cl

InChI

1S/C8H11Cl3O6/c9-8(10,11)7-16-5-3(14)4(2(13)1-12)15-6(5)17-7/h2-7,12-14H,1H2/t2-,3+,4-,5-,6-,7-/m1/s1

InChI key

OJYGBLRPYBAHRT-IPQSZEQASA-N

Application

α-Chloralose has been used as anesthetic in surgical preparations.

Biochem/physiol Actions

α-Chloralose is used as an immobilizing agent. It is mostly used in studies, which involves autonomic reflexes. α-Chloralose is a sedative hypnotic. It has high significance as anesthetic for laboratory animals.

Other Notes

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

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This Item
23120C884945373
α-Chloralose

Sigma-Aldrich

C0128

α-Chloralose

α-Chloralose ≥98.0% (chloralose, AT)

Sigma-Aldrich

23120

α-Chloralose

α-Chloralose−HBC complex ≥92% α-anomer basis

Sigma-Aldrich

C8849

α-Chloralose−HBC complex

Chloralose PESTANAL®, analytical standard

Supelco

45373

Chloralose

solubility

ethanol: 10 mg/mL, clear to slightly hazy, colorless to faintly yellow (or yellow-brown)

solubility

water: soluble 1 gm in 225 ml at 15 °C, chloroform: slightly soluble, diethyl ether: soluble, glacial acetic acid: soluble, petroleum ether: insoluble

solubility

H2O: freely soluble

solubility

-

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

form

powder

form

powder

form

powder

form

-

color

white to off-white

color

-

color

-

color

-

impurities

≤20% β-anomer

impurities

15% Beta-chloralose

impurities

-

impurities

-

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pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Acute Tox. 4 Inhalation - Aquatic Acute 1 - Aquatic Chronic 1 - STOT SE 3

target_organs

Central nervous system

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN9243
BCCK0932
BCCF1953
BCCH8687
BCCC7714

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Preparation of water-soluble compounds by covalent attachment of solubilizing moieties
The Practice of Medicinal Chemistry, 767-785 (2008)
Vertebrate pest control chemicals and their use in urban and rural environments
Hayes' Handbook of Pesticide Toxicology, 271-284 (2010)
Serotonin in the solitary tract nucleus shortens the laryngeal chemoreflex in anaesthetized neonatal rats
Donnelly WT, et al.
Experimental Physiology, 101(7), 946-961 (2016)
View All Related Papers

Global Trade Item Number

SKUGTIN
C0128-100G04061833450208
C0128-500G04061832388939
C0128-1KG04061826058961
C0128-25G04061832388922

Questions

  1. I need to make a 10 mg/ml solution with alpha-chloralose for IV injection in experimental rats. Can I talk to someone for guidance on preparation and storage?

    1 answer

    1. This product is tested for solubility at 10mg/mL in ethanol. This solvent would not be the preferred solvent for use in animal models. This compound is not tested for in vivo use, but is a commonly utilized drug in animal studies. The following reference may be useful for this application:
      A simple method, using 2-hydroxypropyl-?-cyclodextrin, of administering ?-chloralose at room temperature
      https://www.sciencedirect.com/science/article/pii/S0165027097001106?via%3Dihub

      Preparation of Water-Soluble Compounds by Covalent Attachment of Solubilizing Moieties
      https://www.sciencedirect.com/science/article/abs/pii/B9780124172050000304

      (2-Hydroxypropyl)-?-cyclodextrin products
      https://www.sigmaaldrich.com/US/en/substance/12345128446355

      Cyclodextrin overview
      https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/cell-culture-and-cell-culture-analysis/mammalian-cell-culture/cyclodextrins

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