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C130

Chloro-APB hydrobromide

solid

Synonym(s):

(±)-6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide, (±)-SKF-82958 hydrobromide, 6-Chloro-N-allyl-SKF-38393 hydrobromide

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About This Item

Empirical Formula (Hill Notation):
C19H20ClNO2 · HBr
CAS Number:
80751-65-1
Molecular Weight:
410.73
NACRES:
NA.77
PubChem Substance ID:
24277890
UNSPSC Code:
12352200
MDL number:
MFCD00069235
Form:
solid
Quality level:
100
Pricing and availability is not currently available.
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form

solid

Quality Level

100

color

tan

solubility

H2O: 3.7 mg/mL, aqueous base: unstable, ethanol: soluble

storage temp.

2-8°C

SMILES string

Br.Oc1cc2C(CN(CCc2c(Cl)c1O)CC=C)c3ccccc3

InChI

1S/C19H20ClNO2.BrH/c1-2-9-21-10-8-14-15(11-17(22)19(23)18(14)20)16(12-21)13-6-4-3-5-7-13;/h2-7,11,16,22-23H,1,8-10,12H2;1H

InChI key

WLXGFAVTAAQOFH-UHFFFAOYSA-N

Gene Information

human ... DRD1(1812)

Application

Chloro-APB hydrobromide has been used to pharmacologically stimulate D1 dopamine receptors and study its influence on locomotor response in fat mass and obesity-associated protein (FTO) deficient dopamine D1 receptor-expressing medium spiny neurons (D1 MSNs) of mice.[1]

Biochem/physiol Actions

Chloro-APB hydrobromide, also known as SKF 82958, is a D1 dopamine receptor agonist.[1] D1 receptor agonists prevent and reverse fentanyl-induced respiratory depression, without impairing opioid analgesia, in cats.[2]

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This Item
S143D054D047
Chloro-APB hydrobromide solid

Sigma-Aldrich

C130

Chloro-APB hydrobromide

(±)-6-Chloro-PB hydrobromide ≥98% (HPLC), solid

Sigma-Aldrich

S143

(±)-6-Chloro-PB hydrobromide

R(+)-SCH-23390 hydrochloride ≥98% (HPLC), solid

Sigma-Aldrich

D054

R(+)-SCH-23390 hydrochloride

(±)-SKF-38393 hydrochloride crystalline, ≥98% (HPLC)

Sigma-Aldrich

D047

(±)-SKF-38393 hydrochloride

form

solid

form

solid

form

solid

form

crystalline

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

-

storage temp.

-

storage temp.

-

solubility

H2O: 3.7 mg/mL, ethanol: soluble, aqueous base: unstable

solubility

H2O: 1.7 mg/mL, DMSO: >10 mg/mL, ethanol: 6.3 mg/mL

solubility

H2O: >5 mg/mL

solubility

H2O: >5 mg/mL, aqueous base: soluble (unstable)

color

tan

color

white to light tan

color

white

color

white

Gene Information

human ... DRD1(1812)

Gene Information

human ... DRD1(1812)

Gene Information

human ... DRD1(1812)

Gene Information

human ... DRD1(1812)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000461217
0000461217
0000270648
0000270648
075M4609V

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Thomas F Tropea et al.
Biological psychiatry, 63(11), 1066-1074 (2008-02-16)
Prenatal exposure to cocaine can impede normal brain development, triggering a range of neuroanatomical and behavioral anomalies that are evident throughout life. Mouse models have been especially helpful in delineating neuro-teratogenic consequences after prenatal exposure to cocaine. The present study
K D Carr et al.
Neuroscience, 165(4), 1074-1086 (2009-11-26)
Previous findings suggest that neuroadaptations downstream of D-1 dopamine (DA) receptor stimulation in nucleus accumbens (NAc) are involved in the enhancement of drug reward by chronic food restriction (FR). Given the high co-expression of D-1 and GluR1 AMPA receptors in
Thomas P Giordano et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(50), 17051-17062 (2010-12-17)
L-type Ca(2+) channel (LTCC)-activated signaling cascades contribute significantly to psychostimulant-induced locomotor sensitization; however, the precise contribution of the two brain-specific subunits Ca(v)1.2 and Ca(v)1.3 remains mostly unknown. In this study, by using amphetamine and cocaine locomotor sensitization in mutant mice
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