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Anti-c-Myc antibody produced in rabbit

Name: Anti-c-Myc antibody produced in rabbit
Brand: SIGMA
Price: 561 USD
Availability: InStock

~0.5 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Myc Tag Polyclonal Antibody, c-Myc Antibody

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Size/SKU	Availability	Price
100 μg	Available to ship TODAYfromMILWAUKEE	$561.00
0.2 mg	Available to ship TODAYfromMILWAUKEE	$713.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.56

MDL number:

MFCD00239651

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ARR, ICC, IF, IP, WB

Citations:

516

$561.00

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Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

concentration

~0.5 mg/mL

technique(s)

immunocytochemistry: 5-10 μg/mL, immunoprecipitation (IP): 1-2 μg using immunoprecipitates a c-Myc fusion protein from transfected mammalian cell lysates or bacterial extracts, indirect immunofluorescence: 5-10 μg/mL using detects c-Myc fusion proteins in methanol-acetone fixed transiently transfected cells, microarray: suitable, western blot: 0.5-1 μg/mL using detects c-Myc fusion proteins in cell extracts from transfected cultures as well as bacterial lysates.

UniProt accession no.

P01106

storage temp.

−20°C

Gene Information

human ... MYC(4609)

Description

General description

Anti-c-Myc antibody is used for the detection of the c-Myc tag sequence on c-Myc tagged fusion proteins.This polyclonal antibody is produced in rabbit and recognizes the c-Myc sequence at the N-terminus and C-terminus. C3956 is an Affinity purified antibody, increasing sensitivity in most applications.

MYC (MYC proto-oncogene) is a transcriptional factor and oncoprotein. It is located on chromosome 8q24. c-Myc gene codes for basic helix-loop-helix/leucine zipper (bHLH/LZ) transcription factor.

Immunogen

peptide corresponding amino acids 408-425 of the human c-myc proto-oncogene, conjugated to maleimide-activated KLH through a C-terminal added cysteine residue.

Application

Anti-c-Myc antibody has been used in western blotting and immunofluorescence.

Antibody is recommended for use in immunoblotting, immunoprecipitation and immunofluorescence.
.

Biochem/physiol Actions

N-terminal or C-terminal c-Myc (Glu-Gln-Lys-Leu-Ile-Ser-Glu-Glu-Asp-Leu) tagged fusion proteins.

MYC (MYC proto-oncogene) may be essential for cancer initiation, promotion and therapy resistance. Overexpression of MYC in DLBCL (diffuse large B-cell lymphoma) results in poor outcome and invasive treatment when medicated with rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP). The cellular myelocytomatosis (c-myc) oncogene plays a major role in cellular proliferation, differentiation and apoptosis. It acts as transcriptional regulator of gene expression.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

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This Item	A5598	WH0004609M2	C6594
Sigma-Aldrich C3956 Anti-c-Myc antibody produced in rabbit	Sigma-Aldrich A5598 Anti-c-Myc−Peroxidase antibody produced in rabbit	Sigma-Aldrich WH0004609M2 Monoclonal Anti-MYC antibody produced in mouse	Sigma-Aldrich C6594 Monoclonal Anti-c-Myc−Cy3^™ antibody produced in mouse
description ~0.5 mg/mL, affinity isolated antibody, buffered aqueous solution	description affinity isolated antibody, buffered aqueous solution	description clone 1G7, purified immunoglobulin, buffered aqueous solution	description clone 9E10, purified immunoglobulin, buffered aqueous solution
clone polyclonal	clone polyclonal	clone 1G7, monoclonal	clone 9E10, monoclonal
biological source rabbit	biological source rabbit	biological source mouse	biological source mouse
conjugate unconjugated	conjugate peroxidase conjugate	conjugate unconjugated	conjugate CY3 conjugate
species reactivity human	species reactivity human	species reactivity human	species reactivity human
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form purified immunoglobulin	antibody form purified immunoglobulin
Gene Information human ... MYC(4609)	Gene Information human ... MYC(4609)	Gene Information human ... MYC(4609)	Gene Information human ... MYC(4609)

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Storage Class

10 - Combustible liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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