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C6165

Carbonic Anhydrase Isozyme II human

≥80%, powder, ≥3,000 W-A units/mg protein

Synonym(s):

Carbonate Dehydratase, Carbonate Hydrolyase

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1 mg

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About This Item

CAS Number:
9001-03-0
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
232-576-6
MDL number:
MFCD00081467
EC Number:
4.2.1.1 (BRENDA, IUBMB)
Specific activity:
≥3,000 W-A units/mg protein
Assay:
≥80%

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Quality Segment

200

assay

≥80%

form

powder

specific activity

≥3,000 W-A units/mg protein

mol wt

30 kDa

color

white

pI 

~7.4

UniProt accession no.

P00918

storage temp.

−20°C

Gene Information

human ... CA2(760)

Application

Human carbonic anhydrase isozyme II has been used to assess its gene fusion abilities for efficient expression and recovery of recombinant proteins. Human carbonic anhydrase isozyme II has also been used to investigate a new process for the synthesis of difluoromethanesulfonamides. Furthermore, CA II from Sigma has been used as a standard to measure the CA activity in lung tissue homogenates. The study analysed the possible relationship between the expression of carbonic anhydrase and non-small cell lung cancer. The product has also been used with Freund′s complete adjuvant at 1:1 ratio for antibody production. This study evaluated the quantitative and functional alterations of cytosolic CA isoenzymes in the erythrocytes of glucose-6-phosphate dehydrogenase (G6PD)-deficient individuals. The enzyme has also been used in the study of natural phenolic inhibitors of CA II.

Biochem/physiol Actions

Carbonic anhydrase is a zinc metalloenzyme that catalyzes the hydration of carbon dioxide to carbonic acid. It is involved in pathological and physiological processes such as pH and CO2 homeostasis, transport of bicarbonate and CO2, biosynthetic reactions, bone resorption, calcification, and tumorigenicity. Therefore, this enzyme is an important target for inhibitors that can be used for treating various pathological conditions such as glaucoma, epilepsy and Parkinson′s disease. CAII has a molecular mass of approximately 30 kDa and is primarily present in type II pneumocytes. Due to this unique location it has been speculated that CAII is involved in pulmonary functions such as regulation of fluid secretion and CO2 elimation. Sulfonamides, sulfamates and sulfamides are potent inhibitors of CA.

Other Notes

One Wilbur-Anderson (W-A) unit will cause the pH of a 0.02 M Trizma buffer to drop from 8.3 to 6.3 per min at 0 °C. (One W-A unit is essentially equivalent to one Roughton-Booth unit.)

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Carbonic Anhydrase Isozyme II human ≥80%, powder, ≥3,000 W-A units/mg protein

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Carbonic Anhydrase Isozyme II from bovine erythrocytes

Carbonic Anhydrase from bovine erythrocytes lyophilized powder, ≥2,000 W-A units/mg protein

Sigma-Aldrich

C3934

Carbonic Anhydrase from bovine erythrocytes

Carbonic Anhydrase from bovine erythrocytes ≥95% (SDS-PAGE), specific activity ≥3,500 W-A units/mg protein, lyophilized powder

Sigma-Aldrich

C2624

Carbonic Anhydrase from bovine erythrocytes

description

≥80%, powder, ≥3,000 W-A units/mg protein

description

lyophilized powder, ≥3,000 W-A units/mg protein

description

lyophilized powder, ≥2,000 W-A units/mg protein

description

≥95% (SDS-PAGE), specific activity ≥3,500 W-A units/mg protein, lyophilized powder

Gene Information

human ... CA2(760)

Gene Information

-

Gene Information

-

Gene Information

-

assay

≥80%

assay

-

assay

-

assay

≥75% protein basis (biuret), ≥95% (SDS-PAGE)

specific activity

≥3,000 W-A units/mg protein

specific activity

≥3,000 W-A units/mg protein

specific activity

≥2,000 W-A units/mg protein

specific activity

≥3,500 W-A units/mg protein

form

powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

mol wt

30 kDa

mol wt

30 kDa

mol wt

30 kDa

mol wt

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H334

Hazard Classifications

Resp. Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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